1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.87 - homoisocitrate dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.38 - 0.4
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
0.78 - 25
(2R,3S)-3-(2-hydroxyethyl)malate
4.8 - 29
(2R,3S)-3-(3-hydroxypropyl)malate
2 - 8
(2R,3S)-3-(4-hydroxybutyl)malate
0.14 - 3
(2R,3S)-3-(4-pentenyl)malic acid
0.34 - 37
(2R,3S)-3-allylmalic acid
0.7 - 53
(2R,3S)-3-propylmalic acid
171
1-hydroxy-1,2,3-propanetricarboxylate
Thermus thermophilus
-
purified enzyme, pH 8.0, 60C
171
1-hydroxy-1,2,4-butanetricarboxylate
Thermus thermophilus
-
purified enzyme, pH 8.0, 60C
0.371
3-isopropylmalate
Deinococcus radiodurans
-
pH 7.8, 25C, recombinant wild-type enzyme
0.5 - 0.77
3-vinylmalate
0.61 - 43
ethylmalate
5.46 - 46.2
homoisocitrate
10.9 - 438
isocitrate
0.37
isopropylmalate
Deinococcus radiodurans
-
pH 7.8, 28C, recombinant enzyme
0.38 - 0.4
NAD+
0.59
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
Saccharomyces cerevisiae
-
-
2
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
Saccharomyces cerevisiae
-
-