1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.87 - homoisocitrate dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum
Manually annotated by BRENDA team
-
mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum
Manually annotated by BRENDA team
-
inner ear, specific expression of isoform Rdh10 in the endolymphatic system and stria vascularis
Manually annotated by BRENDA team
-
expression of Rdh10 gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation
Manually annotated by BRENDA team
-
mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina
Manually annotated by BRENDA team
-
the 3 kb isoform is the most abundant one
Manually annotated by BRENDA team
-
mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum
Manually annotated by BRENDA team
-
and vibrissae follicles, expression of isoform Rdh10 from early stages in regions where sensory receptors appear and mesenchymal/epithelial interactions take place
Manually annotated by BRENDA team
low activity
Manually annotated by BRENDA team
-
strong expression, the 3 kb isoform is the most abundant one
Manually annotated by BRENDA team
-
mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina
Manually annotated by BRENDA team
-
the 3 kb isoform is the most abundant one
Manually annotated by BRENDA team
additional information
-
no expression in H-460 cells (non-small-cell lung cancer). Very low level of expression is detected in cell lines SKMES (squamous lung cancer) and SCLC (small-cell lung carcinoma)
Manually annotated by BRENDA team