1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

KM Value

KM Value on EC 1.1.1.87 - homoisocitrate dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.074 - 7.5
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
0.59 - 2.1
(2R,3S)-3-(2-hydroxyethyl)malate
0.51 - 0.58
(2R,3S)-3-(3-hydroxypropyl)malate
0.44 - 0.47
(2R,3S)-3-(4-hydroxybutyl)malate
2.7 - 9.4
(2R,3S)-3-(4-pentenyl)malic acid
0.41 - 2.8
(2R,3S)-3-allylmalic acid
0.29 - 0.78
(2R,3S)-3-propylmalic acid
0.4
1-hydroxy-1,2,3-propanetricarboxylate
-
purified enzyme, pH 8.0, 60C
7.5
1-hydroxy-1,2,4-butanetricarboxylate
-
purified enzyme, pH 8.0, 60C
0.06
11-cis-retinol
-
microsomal preparations of RDH10
1.4
3-carboxy-2-hydroxyadipate
-
-
1.33
3-isopropylmalate
-
pH 7.8, 25C, recombinant wild-type enzyme
0.083 - 3.4
3-vinylmalate
0.04 - 6
9-cis-retinol
0.57
all-trans retinal
-
pH 7.4, 37C, wild-type enzyme
0.00018 - 0.0041
all-trans retinol
0.4
all-trans-retinal
-
; microsomal preparations of RDH10
0.035
all-trans-retinol
-
; microsomal preparations of RDH10, cofactor: NAD+
1.5
alpha-ketoadipate
-
-
16.3
CO2
-
reductive carboxylation of alpha-ketoadipate
0.6 - 1
ethylmalate
0.01 - 1.5
homoisocitrate
1.4
homoisocitric acid
-
-
0.0164 - 0.521
isocitrate
1.33
isopropylmalate
-
pH 7.8, 28C, recombinant enzyme
0.0042 - 3.2
Mg-homoisocitrate
0.036 - 9
NAD+
0.065 - 0.11
NADH
0.027
NADP+
-
pH 7.4, 37C, wild-type enzyme
0.015
NADPH
-
pH 7.4, 37C, wild-type enzyme
0.02
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
-
0.15
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
-
additional information
additional information
-