1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.87 - homoisocitrate dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3S)-3-(p-carboxybenzyl)malate
-
-
(2S)-thiahomocitrate
-
-
(2S,3S)-(-)-3-methylmercaptomalic acid
-
(2S,3S)-thiahomoisocitrate
interacts through hydrogen bonding to Arg 118, Tyr 125 and Lys 171 in the active site, enzyme binding structure, overview
(R,E)-(3-carboxypropylidene)malic acid
(R,E)-(3-hydroxypropylidene)malic acid
(R,Z)-(3-carboxypropylidene)malic acid
(R,Z)-(3-hydroxypropylidene)malic acid
11-cis-retinol
-
substrate inhibition above 0.005 mM
2-oxoadipate
Saccharomycopsis lipolytica
-
-
3-carboxypropylidenemalate
-
-
3-vinylmalate
-
-
3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
-
9-cis-retinol
-
substrate inhibition above 0.001 mM
acetate
-
slight inhibition
all-trans-retinol
-
substrate inhibition
homoisocitrate
Mg-homoisocitrate
-
-
NAD+
-
substrate inhibition at high concentrations and in absence of K+, kinetics, overview
Oxaloglutarate
Saccharomycopsis lipolytica
-
-
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
-
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
-
trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
-
additional information
-