1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 11-cis-RDH, 11-cis-retinol dehydrogenase, 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), atRDH, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, RDH10, retinol dehydrogenase 10, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

KI Value

KI Value on EC 1.1.1.87 - homoisocitrate dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.013
(2S,3S)-thiahomoisocitrate
pH 7.8, 60C
0.79 - 3.1
(R,E)-(3-carboxypropylidene)malic acid
1.4 - 5.2
(R,E)-(3-hydroxypropylidene)malic acid
0.072 - 0.26
(R,Z)-(3-carboxypropylidene)malic acid
0.51 - 15.3
(R,Z)-(3-hydroxypropylidene)malic acid
0.088
3-vinylmalate
-
pH 7.8, 28C, recombinant enzyme
12
3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
-
0.002
Mg-homoisocitrate
-
oxidate decarboxylation of homoisocitrate
77
NAD+
-
pH 8.0, 25C, in absence of KOAc
0.01
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
-
0.000097
trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
-