1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version, for detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD+
=
2-oxoadipate
+
CO2
+
NADH
+
H+

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, protein PH1722, ScHICDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.87 homoisocitrate dehydrogenase

Reference

Reference on EC 1.1.1.87 - homoisocitrate dehydrogenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ye, Z.H.; Bhattacharjee, J.K.
Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe
J. Bacteriol.
170
5968-5970
1988
Schizosaccharomyces pombe
Manually annotated by BRENDA team
Garrad, R.C.; Bhattacharjee, J.K.
Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans
J. Bacteriol.
174
7379-7384
1992
Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rowley, B.; Tucci, A.F.
Homoisocitric dehydrogenase from yeast
Arch. Biochem. Biophys.
141
499-510
1970
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gaillardin, C.M.; Ribet, A.M.; Heslot, H.
Wild-type and mutant forms of homoisocitric dehydrogenase in the yeast Saccharomycopsis lipolytica
Eur. J. Biochem.
128
489-494
1982
Saccharomycopsis lipolytica
Manually annotated by BRENDA team
Broquist, H.P.
Homoisocitric Dehydrogenase
Methods Enzymol.
17B
118-119
1971
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Strassmann, M.; Ceci, L.N.
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid
J. Biol. Chem.
240
4357-4361
1965
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Miyazaki, J.; Kobashi, N.; Nishiyama, M.; Yamane, H.
Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase
J. Biol. Chem.
278
1864-1871
2003
Thermus thermophilus
Manually annotated by BRENDA team
Miyazaki, K.
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase
Biochem. Biophys. Res. Commun.
331
341-346
2005
Pyrococcus horikoshii (A4CYJ9), Pyrococcus horikoshii
Manually annotated by BRENDA team
Miyazaki, K.
Identification of a novel trifunctional homoisocitrate dehydrogenase and modulation of the broad substrate specificity through site-directed mutagenesis
Biochem. Biophys. Res. Commun.
336
596-602
2005
Deinococcus radiodurans
Manually annotated by BRENDA team
Yamamoto, T.; Miyazaki, K.; Eguchi, T.
Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase
Bioorg. Med. Chem.
15
1346-1355
2007
Deinococcus radiodurans, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Miyazaki, J.; Asada, K.; Fushinobu, S.; Kuzuyama, T.; Nishiyama, M.
Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, Thermus thermophilus: involvement of hydrophobic dimer-dimer interaction in extremely high thermotolerance
J. Bacteriol.
187
6779-6788
2005
Thermus thermophilus
Manually annotated by BRENDA team
Lin, Y.; Volkman, J.; Nicholas, K.M.; Yamamoto, T.; Eguchi, T.; Nimmo, S.L.; West, A.H.; Cook, P.F.
Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
Biochemistry
47
4169-4180
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yamamoto, T.; Eguchi, T.
Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway
Bioorg. Med. Chem.
16
3372-3376
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sandell, L.L.; Sanderson, B.W.; Moiseyev, G.; Johnson, T.; Mushegian, A.; Young, K.; Rey, J.P.; Ma, J.X.; Staehling-Hampton, K.; Trainor, P.A.
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development
Genes Dev.
21
1113-1124
2007
Mus musculus
Manually annotated by BRENDA team
Romand, R.; Kondo, T.; Cammas, L.; Hashino, E.; Dolle, P.
Dynamic expression of the retinoic acid-synthesizing enzyme retinol dehydrogenase 10 (rdh10) in the developing mouse brain and sensory organs
J. Comp. Neurol.
508
879-892
2008
Mus musculus
Manually annotated by BRENDA team
Lin, Y.; West, A.H.; Cook, P.F.
Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
Biochemistry
47
10809-10815
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lin, Y.; West, A.H.; Cook, P.F.
Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
Biochemistry
48
7305-7312
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gabriel, I.; Vetter, N.D.; Palmer, D.R.; Milewska, M.J.; Wojciechowski, M.; Milewski, S.
Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
FEMS Yeast Res.
13
143-155
2013
Candida albicans, Candida albicans ATCC 10231
Manually annotated by BRENDA team
Nango, E.; Yamamoto, T.; Kumasaka, T.; Eguchi, T.
Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor
J. Biochem.
150
607-614
2011
Thermus thermophilus (Q5SIJ1), Thermus thermophilus
Manually annotated by BRENDA team
Hsu, C.; West, A.H.; Cook, P.F.
Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme
Arch. Biochem. Biophys.
584
20-27
2015
Saccharomyces cerevisiae (P40495), Saccharomyces cerevisiae
Manually annotated by BRENDA team