show reference and datareference onlydata only

Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase

Data extracted from this reference:

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.0164

-

isocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

0.0183

-

homoisocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

Metals/Ions

Commentary

Organism

Structure

Mn2+

-

Pyrococcus horikoshii

Turnover Number Minimum [1/s]

Turnover Number Maximum [1/s]

Substrate

Commentary

Organism

Structure

13.7

-

homoisocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

14.8

-

isocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

Cofactor

Commentary

Organism

Structure

NAD+

-

Pyrococcus horikoshii

Cofactor

Commentary

Organism

Structure

NAD+

-

Pyrococcus horikoshii

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.0164

-

isocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

0.0183

-

homoisocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

Metals/Ions

Commentary

Organism

Structure

Mn2+

-

Pyrococcus horikoshii

Turnover Number Minimum [1/s]

Turnover Number Maximum [1/s]

Substrate

Commentary

Organism

Structure

13.7

-

homoisocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

14.8

-

isocitrate

pH 7.8, 70°C, recombinant enzyme

Pyrococcus horikoshii

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

739958

Hsu

Evidence for an induced confor ...

Saccharomyces cerevisiae

Arch. Biochem. Biophys.

584

20-27

2015

-

-

1

-

3

-

2

1

-

2

-

1

-

3

-

-

1

1

-

-

-

-

2

-

1

-

-

-

1

1

-

2

-

-

-

-

-

1

2

-

3

-

-

2

-

1

-

2

-

1

-

-

-

1

-

-

-

-

2

-

1

-

-

-

1

1

-

-

-

3

3

-

-

-

722303

Gabriel

Homoisocitrate dehydrogenase f ...

Candida albicans, Candida albicans ATCC 10231

FEMS Yeast Res.

13

143-155

2013

-

-

1

-

-

-

3

4

-

2

3

2

-

8

-

-

1

-

-

-

-

-

6

2

1

-

-

4

1

-

-

1

-

-

3

-

-

1

1

-

-

-

3

3

-

4

-

2

3

2

-

-

-

1

-

-

-

-

6

2

1

-

-

4

1

-

-

-

-

1

1

-

4

4

722569

Nango

Structure of Thermus thermophi ...

Thermus thermophilus

J. Biochem.

150

607-614

2011

-

-

-

1

-

-

2

1

-

1

-

1

-

5

-

-

-

-

-

-

-

-

2

-

1

-

-

-

1

-

-

1

1

-

-

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1

1

-

-

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2

1

1

-

1

-

1

-

-

-

-

-

-

-

-

2

-

1

-

-

-

1

-

-

-

-

1

1

-

-

-

696350

Lin

Site-directed mutagenesis as a ...

Saccharomyces cerevisiae

Biochemistry

48

7305-7312

2009

-

-

-

-

2

-

-

1

-

2

-

1

-

2

-

-

-

-

-

-

-

-

2

-

1

-

-

-

2

1

-

1

-

-

-

-

-

-

1

-

2

-

-

-

-

1

-

2

-

1

-

-

-

-

-

-

-

-

2

-

1

-

-

-

2

1

-

-

-

-

-

-

-

-

685232

Lin

Chemical mechanism of homoisoc ...

Saccharomyces cerevisiae

Biochemistry

47

4169-4180

2008

-

-

-

-

-

-

2

5

-

1

-

-

-

2

-

-

-

1

-

-

-

-

4

-

3

-

-

-

1

-

1

-

1

-

-

-

-

-

-

-

-

-

-

2

1

5

-

1

-

-

-

-

-

-

-

-

-

-

4

-

3

-

-

-

1

-

1

-

-

-

-

-

-

-

685539

Yamamoto

Thiahomoisocitrate: a highly p ...

Saccharomyces cerevisiae

Bioorg. Med. Chem.

16

3372-3376

2008

-

-

-

-

-

-

4

3

-

1

-

-

-

4

-

-

-

-

-

-

-

-

3

-

-

-

-

3

1

-

-

-

3

-

-

-

-

-

-

-

-

-

-

4

3

3

-

1

-

-

-

-

-

-

-

-

-

-

3

-

-

-

-

3

1

-

-

-

-

-

-

-

-

-

687988

Romand

Dynamic expression of the reti ...

Mus musculus

J. Comp. Neurol.

508

879-892

2008

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

9

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

9

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

696220

Lin

Potassium is an activator of h ...

Saccharomyces cerevisiae

Biochemistry

47

10809-10815

2008

-

-

-

-

-

-

4

3

-

5

-

1

-

2

-

-

-

-

-

-

-

-

3

-

1

-

-

-

1

1

-

1

1

-

-

-

-

-

1

-

-

-

-

4

1

3

-

5

-

1

-

-

-

-

-

-

-

-

3

-

1

-

-

-

1

1

-

-

-

-

-

-

-

-

667934

Yamamoto

Substrate specificity analysis ...

Deinococcus radiodurans, Saccharomyces cerevisiae

Bioorg. Med. Chem.

15

1346-1355

2007

-

-

1

-

-

-

11

20

-

2

-

-

-

7

-

-

1

-

-

-

2

-

24

-

2

-

-

20

2

-

-

2

9

-

-

-

-

1

2

-

-

-

-

11

9

20

-

2

-

-

-

-

-

1

-

-

2

-

24

-

2

-

-

20

2

-

-

-

-

-

-

-

-

-

686950

Sandell

RDH10 is essential for synthes ...

Mus musculus

Genes Dev.

21

1113-1124

2007

-

-

-

-

1

-

-

-

-

-

-

1

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

660907

Miyazaki

Bifunctional isocitrate-homois ...

Pyrococcus horikoshii

Biochem. Biophys. Res. Commun.

331

341-346

2005

-

-

1

-

-

-

-

2

-

1

-

4

-

3

-

-

1

-

-

-

1

-

4

-

1

-

-

2

1

-

-

1

-

-

-

-

-

1

1

-

-

-

-

-

-

2

-

1

-

4

-

-

-

1

-

-

1

-

4

-

1

-

-

2

1

-

-

-

-

-

-

-

-

-

660918

Miyazaki

Identification of a novel trif ...

Deinococcus radiodurans

Biochem. Biophys. Res. Commun.

336

596-602

2005

-

-

1

-

4

-

-

7

-

2

2

-

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4

-

-

1

-

-

-

1

-

3

1

1

-

-

7

1

-

-

1

-

-

-

-

-

1

1

-

4

-

-

-

-

7

-

2

2

-

-

-

-

1

-

-

1

-

3

1

1

-

-

7

1

-

-

-

-

-

-

-

-

-

669109

Miyazaki

Crystal structure of tetrameri ...

Thermus thermophilus

J. Bacteriol.

187

6779-6788

2005

-

-

-

1

1

-

-

2

-

1

-

-

-

2

-

-

-

-

-

-

1

-

3

1

1

-

-

2

1

-

-

1

-

-

-

-

-

-

1

1

1

-

-

-

-

2

-

1

-

-

-

-

-

-

-

-

1

-

3

1

1

-

-

2

1

-

-

-

-

-

-

-

-

-

656127

Miyazaki

Characterization of homoisocit ...

Thermus thermophilus

J. Biol. Chem.

278

1864-1871

2003

-

-

1

-

1

-

-

2

-

-

-

1

-

3

-

-

1

-

-

-

2

-

4

-

-

-

2

2

-

-

-

1

-

-

-

-

-

1

1

-

1

-

-

-

-

2

-

-

-

1

-

-

-

1

-

-

2

-

4

-

-

-

2

2

-

-

-

-

-

-

-

-

-

-

644538

Garrad

Lysine biosynthesis in selecte ...

Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae

J. Bacteriol.

174

7379-7384

1992

-

3

1

-

-

-

-

-

-

-

-

4

-

11

-

-

-

-

-

-

4

-

7

-

-

-

-

-

-

-

-

-

-

-

-

-

3

1

-

-

-

-

-

-

-

-

-

-

-

4

-

-

-

-

-

-

4

-

7

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288190

Ye

Lysine biosynthesis pathway an ...

Schizosaccharomyces pombe

J. Bacteriol.

170

5968-5970

1988

-

-

-

-

-

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1

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1

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2

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-

-

-

-

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-

-

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-

-

-

1

-

-

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-

-

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-

-

2

-

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-

-

-

-

-

-

-

-

-

644540

Gaillardin

Wild-type and mutant forms of ...

Saccharomycopsis lipolytica

Eur. J. Biochem.

128

489-494

1982

-

-

-

-

-

2

3

-

-

3

1

1

-

3

-

-

1

-

-

-

1

2

2

2

1

-

-

-

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-

2

-

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2

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2

-

3

-

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3

1

1

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1

-

-

1

2

2

2

1

-

-

-

-

-

-

-

-

-

-

-

-

-

644541

Broquist

-

Homoisocitric Dehydrogenase ...

Saccharomyces cerevisiae

Methods Enzymol.

17B

118-119

1971

-

-

-

-

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-

-

1

-

1

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1

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1

-

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1

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1

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-

1

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2

-

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2

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1

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1

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1

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1

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1

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1

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-

644539

Rowley

Homoisocitric dehydrogenase fr ...

Saccharomyces cerevisiae

Arch. Biochem. Biophys.

141

499-510

1970

2

-

-

-

-

-

1

4

-

3

1

1

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2

-

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1

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1

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1

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2

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1

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1

1

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1

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3

-

1

-

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2

2

-

-

-

-

-

-

-

-

644543

Strassmann

Enzymatic formation of alpha-k ...

Saccharomyces cerevisiae

J. Biol. Chem.

240

4357-4361

1965

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-

-

-

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1

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1

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1

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2

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1

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