1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

malic enzyme, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)

Reference

Reference on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Driscoll, B.T.; Finan, T.M.
Properties of NAD+ and NADP+-depemndent malic enzymes of Rhizobium (Sinorhizobium) meliloti and differential expression of their genes in nitrogen-fixing bacteroids
Microbiology
143
489-498
1997
Sinorhizobium meliloti
Manually annotated by BRENDA team
Chooback, L.; Karsten, W.E.; Kulkarni, G.; Nalabolu, S.R.; Harris, B.G.; Cook, P.F.
Expression, purification, and characterization of the recombinant NAD-malic renzyme from Ascaris suum
Protein Expr. Purif.
10
51-54
1997
Ascaris suum
Manually annotated by BRENDA team
Srivatava, G.C.; Yanru, Z.Y.; Pandey, M.; Prasad, N.K.
Effect of silver nitrate on activity of malic enzyme during ripening in mango, Mangifera indica L.
Indian J. Exp. Biol.
34
575-576
1996
Mangifera indica
-
Manually annotated by BRENDA team
Viljoen, M.; van der Merwe, M.; Subden, R.E.; van Vuuren, H.J.J.
Mutation of Gly-444 inactivates the S. pombe malic enzyme
FEMS Microbiol. Lett.
167
157-162
1998
Schizosaccharomyces pombe
Manually annotated by BRENDA team
Karsten, W.E.; Cook, P.F.
Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: a reinvestigation
Biochemistry
33
2096-2103
1994
Ascaris suum
Manually annotated by BRENDA team
Driscoll, B.T.; Finan, T.M.
NAD+-dependent malic enzyme of Rhizobium meliloti is required for symbiotic nitrogen fixation
Mol. Microbiol.
7
865-873
1993
Sinorhizobium meliloti
Manually annotated by BRENDA team
Furbank, R.T.; Agostino, A.M.; Hatch, M.D.
Regulation of C4 photosynthesis: modulation of mitochondrial NAD-malic enzyme by adenylates
Arch. Biochem. Biophys.
289
376-381
1991
Atriplex spongiosa, Panicum miliaceum, Urochloa panicoides
Manually annotated by BRENDA team
Rao, J.G.S.; Harris, B.G.; Cook, P.F.
Diethylpyrocarbonate inactivation of NAD-malic enzyme from Ascaris suum
Arch. Biochem. Biophys.
241
67-74
1985
Ascaris suum
Manually annotated by BRENDA team
Park, S-H.; Harris, B.G.; Cook, P.F.
pH Dependence of kinetic parameters for oxalacetate decarboxylation and pyruvate reduction reactions catalyzed by malic enzyme
Biochemistry
25
3752-3759
1986
Ascaris suum
Manually annotated by BRENDA team
Park, S-H.; Kiick, D.M.; Harris, B.G.; Cook, P.F.
Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum
Biochemistry
23
5446-5453
1984
Ascaris suum
Manually annotated by BRENDA team
Kiick, D.M.; Allen, B.L.; Rao, J.G.S.; Harris, B.G.; Cook, P.F.
Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate
Biochemistry
23
5454-5459
1984
Ascaris suum
Manually annotated by BRENDA team
Cook, R.A.
Distinct metal cofactor-induced conformational states in the NAD-specific malic enzyme of Escherichia coli as revealed by proteolysis studies
Biochim. Biophys. Acta
749
198-203
1983
Escherichia coli
Manually annotated by BRENDA team
Yamaguchi, M.
Studies on regulatory functions of malic enzymes. IV. Effects of sulfhydryl group modification on the catalytic function of NAD-linked malic enzyme from Escherichia coli
J. Biochem.
86
325-333
1979
Escherichia coli
Manually annotated by BRENDA team
Milne, J.A.; Cook, R.A.
Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide specific malic enzyme depending on whether Mg2+ or Mn2+ serves as divalent cation
Biochemistry
18
3605-3610
1979
Escherichia coli
-
Manually annotated by BRENDA team
Rhathnam, C.K.M.
Studies with isolated bundle sheath mitochondria. Evidence for NAD-malic enzyme-catalyzed decarboxylation of C4 acids in species representing the three C4 metabolic subtypes
FEBS Lett.
96
367-372
1978
Digitaria sanguinalis, Eleusine indica, Eriochloa borumensis, Megathyrsus maximus, Panicum miliaceum, Zea mays
-
Manually annotated by BRENDA team
Iwakura, M.; Tokushige, M.; Katsuki, H.; Muramatsu, S.
Studies on regulatory functions of malic enzymes. V. Comparative studies of malic enzymes in bacteria
J. Biochem.
83
1387-1394
1978
Agrobacterium tumefaciens, Citrobacter freundii, Clostridium tetanomorphum, Enterobacter aerogenes, Enterobacter aerogenes IFO 3320, Erwinia aroidea, Escherichia coli B, Escherichia coli K-12, Escherichia coli W, Proteus vulgaris
Manually annotated by BRENDA team
Landsperger, W.J.; Harris, B.G.
NAD+-malic enzyme. Regulatory properties of the enzyme from Ascaris suum
J. Biol. Chem.
251
3599-3602
1976
Ascaris suum
Manually annotated by BRENDA team
Yamaguchi, M.; Tokushige, M.; Takeo, K.; Katsuki, H.
Studies on the regulatory functions of malic enzymes: III. Regulatory effects of L-aspartate, Coenzyme A, and divalent metal ions on NAD-linked malic enzyme from Escherichia coli
J. Biochem.
76
1259-1268
1974
Escherichia coli W
Manually annotated by BRENDA team
Schutz, M.; Radler, F.
Das 'Malatenzym' von Lactobacillus plantarum und Leuconostoc mesenteroides
Arch. Mikrobiol.
91
183-202
1973
Lactobacillus plantarum, Lactobacillus plantarum B38, Leuconostoc mesenteroides
Manually annotated by BRENDA team
Fuck, E.; Stärk, G.; Radler, F.
-pfelsäurestoffwechsel bei Saccharomyces II. Anreicherung und Eigenschaften eines Malatenzymes
Arch. Mikrobiol.
89
223-231
1973
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yamaguchi M.; Tokushige, M.; Katsuki, H.
Studies on regulatory functions of malic enzymes II. Purification and molecular properties of nicotinamide adenine dinucleotide-linked malic enzyme from Escherichia coli
J. Biochem.
73
169-180
1973
Escherichia coli W
Manually annotated by BRENDA team
Sauer, L.A.
An NAD- and NADP-dependent malic enzyme with regulatory properties in rat liver and adrenal cortex mitochondrial fractions
Biochem. Biophys. Res. Commun.
50
524-531
1973
Rattus norvegicus
Manually annotated by BRENDA team
Kaufman, S.; Korkes, S.; del Campillo, A.
Biosynthesis of dicarboxylic acids by carbon dioxide filtration V. Further study of the 'malic' enzyme of Lactobacillus arabinosus
J. Biol. Chem.
192
301-312
1951
Lactobacillus plantarum
Manually annotated by BRENDA team
Sawada, S.; Sakamoto, T.; Sato, M.; Kasai, M.; Usuda, H.
Photosynthesis with single-rooted Amaranthus leaves. II. Regulation of ribulose-1,5-bisphosphate carboxylase, phosphoenolpyruvate carboxylase, NAD-malic enzyme and NAD-malate dehydrogenase and coordination between PCR and C4 photosynthetic metabolism in response to changes in the source-sink balance
Plant Cell Physiol.
43
1293-1301
2002
Amaranthus hybridus subsp. cruentus
Manually annotated by BRENDA team
Lara, M.V.; Drincovich, M.F.; Andreo, C.S.
Induction of a crassulacean acid-like metabolism in the C(4) succulent plant, Portulaca oleracea L: study of enzymes involved in carbon fixation and carbohydrate metabolism
Plant Cell Physiol.
45
618-626
2004
Portulaca oleracea
Manually annotated by BRENDA team
Aktas, D.F.; Cook, P.F.
Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction
Biochemistry
47
2539-2546
2008
Ascaris suum, Ascaris suum (P27443)
Manually annotated by BRENDA team
Wang, J.; Tan, H.; Zhao, Z.K.
Over-expression, purification, and characterization of recombinant NAD-malic enzyme from Escherichia coli K12
Protein Expr. Purif.
53
97-103
2007
Escherichia coli K-12
Manually annotated by BRENDA team
MacDonald, M.J.; Longacre, M.J.; Kendrick, M.A.
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells
Arch. Biochem. Biophys.
488
100-104
2009
Homo sapiens (P23368), Mus musculus (Q99KE1), Rattus norvegicus
Manually annotated by BRENDA team
Zheng, H.; Ohno, Y.; Nakamori, T.; Suye, S.
Production of L-malic acid with fixation of HCO3(-) by malic enzyme-catalyzed reaction based on regeneration of coenzyme on electrode modified by layer-by-layer self-assembly method
J. Biosci. Bioeng.
107
16-20
2009
Brevundimonas diminuta, Brevundimonas diminuta IFO13182
Manually annotated by BRENDA team
Hou, S.; Liu, W.; Ji, D.; Zhao, Z.K.
Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
Bioorg. Med. Chem. Lett.
21
1667-1669
2011
Escherichia coli, Escherichia coli (P26616)
Manually annotated by BRENDA team