Disease on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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DISEASE
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Acidosis
Contribution of Malate and Amino Acid Metabolism to Cytoplasmic pH Regulation in Hypoxic Maize Root Tips Studied Using Nuclear Magnetic Resonance Spectroscopy.
The kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies.
Breast Neoplasms
Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line.
Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell.
Purification and characterization of the cytosolic NADP(+)-dependent malic enzyme from human breast cancer cell line.
Carcinogenesis
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Carcinoma
Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence.
High malic enzyme activity in tumor cells and its cross-reaction with anti-pigeon liver malic enzyme serum.
Response of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme to constant infusions of L-triiodothyronine in rats bearing the Walker 256 carcinoma. Evidence for divergent postreceptor regulation of the thyroid hormone response.
Carcinoma, Hepatocellular
Control and function of the transamination pathways of glutamine oxidation in tumour cells.
Hydroperoxide-stimulated release of calcium from rat liver and AS-30D hepatoma mitochondria.
Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription.
Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme.
Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas.
Variation of hepatic malic enzyme capacity with hepatoma susceptibility in mice of different genotypes.
Carcinoma, Non-Small-Cell Lung
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Carcinoma, Squamous Cell
Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence.
Coma
Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle.
Dehydration
Leaf anatomy and photosynthetic carbon metabolic characteristics in Phragmites communis in different soil water availability
The activities of PEP carboxylase and the C(4) acid decarboxylases are little changed by drought stress in three C(4) grasses of different subtypes.
Diabetes Mellitus, Experimental
Changes in malic enzyme in brain during alloxan diabetes.
Diabetic Nephropathies
Effect of yam (Dioscorea cayenensis) and dasheen (Colocassia esculenta) extracts on the kidney of streptozotocin-induced diabetic rats.
Fatty Liver
Biochemical changes associated with the fatty liver syndrome in cows.
Biochemical changes in liver and blood during liver fattening in rats.
Pharmacokinetic changes of several antibiotics in chickens during induced fatty liver.
Some lipogenic enzyme activities in rat livers in which an excessive fat accumulation occurred due to feeding low-level amino acid mixture diets.
Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats.
Fatty Liver, Alcoholic
Hepatic lipogenesis and mobilization of peripheral fats in the formation of alcoholic fatty liver.
Friedreich Ataxia
Cardiac malic enzyme in Friedreich's disease.
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Friedreich's ataxia: malic enzyme activity in cellular fractions of cultured skin fibroblasts.
Friedreich's disease: IV. Reduced mitochondrial malic enzyme activity in heterozygotes.
Gastrointestinal Neoplasms
Tumor-associated metabolic alterations in patients with gastric and esophageal cancer.
Hepatomegaly
Effect of clofibrate on plasma lipid concentration and liver malic enzyme gene expression in rats with experimental chronic renal failure.
Regulation of hepatic malic enzyme by perfluorodecanoic acid.
Hypercholesterolemia
Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes.
Hyperglycemia
Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats.
The effect of prolonged hyperglycemia on metabolic alterations in the subtotally pancreatectomized rat.
Hyperinsulinism
Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats.
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Hyperlipidemias
Peroxisome proliferators as adjuvants for the reverse-electron-transport therapy of obesity: an explanation for the large increase in metabolic rate of MEDICA 16-treated rats.
Hypersensitivity
Cell-specific regulation of transcription of the malic enzyme gene: characterization of cis-acting elements that modulate nuclear T3 receptor activity.
Nutritional regulation and tissue-specific expression of the malic enzyme gene in the chicken. Transcriptional control and chromatin structure.
The effect of thyroid hormone on the chromatin structure and expression of the malic enzyme gene in hepatocytes.
Triiodothyronine stimulates and cyclic AMP inhibits transcription of the gene for malic enzyme in chick embryo hepatocytes in culture.
Hyperthyroidism
Changes in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or diet.
Malic enzyme of hyperthyroid rat liver.
Tissue-specific regulation of malic enzyme by thyroid hormone in the neonatal rat.
Hyperthyroxinemia
The effect of in vivo thyroxine treatment on insulin receptors, glucose transport and GLUT4 in rat adipocytes.
Hypertriglyceridemia
Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil.
Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity.
Hypothyroidism
Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood.
Tissue-specific regulation of malic enzyme by thyroid hormone in the neonatal rat.
Infection
Complex spatial responses to cucumber mosaic virus infection in susceptible Cucurbita pepo cotyledons.
Effect of immature Schistosoma mansoni worms on hamsters' plasma enzymes.
Insulinoma
Chronic reduction of the cytosolic or NAD(P)-mitochondrial malic enzyme does not affect insulin secretion in a rat insulinoma cell line.
Intestinal Volvulus
Inhibition of NADP-linked malic enzyme from Onchocerca volvulus and Dirofilaria immitis by suramin.
Kidney Failure, Chronic
Effect of clofibrate on plasma lipid concentration and liver malic enzyme gene expression in rats with experimental chronic renal failure.
Leukemia
Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements.
Lung Neoplasms
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Lymphoma
Deficiency of malic enzyme: a possible marker for malignancy in lymphoid cells.
malate dehydrogenase (decarboxylating) deficiency
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
malate dehydrogenase (oxaloacetate-decarboxylating) deficiency
Enzyme changes associated with mitoichondrial malic enzyme deficiency in mice.
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Survey of normal appearing mouse strain which lacks malic enzyme and Nad+-linked glycerol phosphate dehydrogenase: normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle.
Malnutrition
Effect of nutritional deficiencies on synthesis of the inducible malic enzyme of Lactobacillus plantarum.
Melanoma
Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.
Neoplasms
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Characterization of cytosolic malic enzyme in human tumor cells.
Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases.
Deficiency of malic enzyme: a possible marker for malignancy in lymphoid cells.
Effect of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzyme, 2-oxoglutarate and isocitrate dehydrogenases.
Effect of tumors with different growth rates on enzymes in host liver.
Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions.
High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival.
High malic enzyme activity in tumor cells and its cross-reaction with anti-pigeon liver malic enzyme serum.
Hormonal and dietary regulation of hepatic enzymes in tumor-bearing rats.
Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli.
Hydroperoxide-stimulated release of calcium from rat liver and AS-30D hepatoma mitochondria.
Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria.
Inhibition of human cancer cell growth by periodate-oxidized 3-aminopyridine adenine dinucleotide phosphate.
Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line.
Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme.
Malic enzyme and malate dehydrogenase activities in rat tracheal epithelial cells during the progression of neoplasia.
Nuclear thyroid hormone receptors, alpha-glycerophosphate dehydrogenases, and malic enzyme in N-nitrosomethylurea-induced rat mammary tumors.
Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly.
Purification and characterization of the cytosolic NADP(+)-dependent malic enzyme from human breast cancer cell line.
Purification of tumor mitochondrial malic enzyme by specific ligand affinity chromatography.
Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria.
The effects of a biological response modifier, OK-432, on tumor-induced alterations in the host metabolism.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Tumor-associated metabolic alterations in patients with gastric and esophageal cancer.
Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity.
Obesity
[Obesity, malic enzyme and aging--an animal experiment study]
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity.
Starvation
Age and thyroid hormone as factors in the responses of BHE rats to starvation-refeeding.
Characterization of a polypyrimidine/polypurine tract in the promoter of the gene for chicken malic enzyme.
Dietary induction of hepatic glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and malic enzyme in lean and obese female Zucker rats.
Effect of diet on adenylosuccinase activity in various organs of rat and chicken.
Effect of prolonged starvation on the activities of malic enzyme and acetylcholinesterase in tissues of Japanese quail.
Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes.
Malic enzyme and fatty acid synthase in the uropygial gland and liver of embryonic and neonatal ducklings. Tissue-specific regulation of gene expression.
Metabolic changes in the African fruit beetle, Pachnoda sinuata, during starvation.
Molecular cloning and characterization of the sheep malic enzyme cDNA.
Nutritional and hormonal regulation of the gene for malic enzyme.
Nutritional regulation of nucleosomal structure at the chicken malic enzyme promoter in liver.
Nutritional regulation of the synthesis and degradation of malic enzyme messenger RNA in duck liver.
Organ specific regulation of malic enzyme and hexosemonophosphate shunt dehydrogenases activity by high carbohydrate diet.
Phosphate Starvation Inducible ;Bypasses' of Adenylate and Phosphate Dependent Glycolytic Enzymes in Brassica nigra Suspension Cells.
Regulation of genes for enzymes involved in fatty acid synthesis.
The chicken malic enzyme gene: structural organization and identification of triiodothyronine response elements in the 5'-flanking DNA.