BRENDA - Enzyme Database show
show all sequences of 1.1.1.38

Photosynthesis with single-rooted Amaranthus leaves. II. Regulation of ribulose-1,5-bisphosphate carboxylase, phosphoenolpyruvate carboxylase, NAD-malic enzyme and NAD-malate dehydrogenase and coordination between PCR and C4 photosynthetic metabolism in response to changes in the source-sink balance

Sawada, S.; Sakamoto, T.; Sato, M.; Kasai, M.; Usuda, H.; Plant Cell Physiol. 43, 1293-1301 (2002)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
in vivo inhibition of the enzyme by oxidation, activity in leaves held under continuous light is reduced by 20-40%
Amaranthus hybridus subsp. cruentus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(S)-malate + NAD+
Amaranthus hybridus subsp. cruentus
regulation of the pathway, metabolic flux and source-sink study, C4 photosynthetic metabolism in response to changes in the source-sink balance, modeling of a system of single-rooted leaves without petioles, overview
pyruvate + CO2 + NADH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Amaranthus hybridus subsp. cruentus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Amaranthus hybridus subsp. cruentus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.46
-
below, extract from leaves under continuous light conditions
Amaranthus hybridus subsp. cruentus
0.58
-
below, leaf extract
Amaranthus hybridus subsp. cruentus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-malate + NAD+
-
656977
Amaranthus hybridus subsp. cruentus
pyruvate + CO2 + NADH
-
-
-
?
(S)-malate + NAD+
regulation of the pathway, metabolic flux and source-sink study, C4 photosynthetic metabolism in response to changes in the source-sink balance, modeling of a system of single-rooted leaves without petioles, overview
656977
Amaranthus hybridus subsp. cruentus
pyruvate + CO2 + NADH
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Amaranthus hybridus subsp. cruentus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Amaranthus hybridus subsp. cruentus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Amaranthus hybridus subsp. cruentus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Amaranthus hybridus subsp. cruentus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
in vivo inhibition of the enzyme by oxidation, activity in leaves held under continuous light is reduced by 20-40%
Amaranthus hybridus subsp. cruentus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(S)-malate + NAD+
Amaranthus hybridus subsp. cruentus
regulation of the pathway, metabolic flux and source-sink study, C4 photosynthetic metabolism in response to changes in the source-sink balance, modeling of a system of single-rooted leaves without petioles, overview
pyruvate + CO2 + NADH
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Amaranthus hybridus subsp. cruentus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.46
-
below, extract from leaves under continuous light conditions
Amaranthus hybridus subsp. cruentus
0.58
-
below, leaf extract
Amaranthus hybridus subsp. cruentus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-malate + NAD+
-
656977
Amaranthus hybridus subsp. cruentus
pyruvate + CO2 + NADH
-
-
-
?
(S)-malate + NAD+
regulation of the pathway, metabolic flux and source-sink study, C4 photosynthetic metabolism in response to changes in the source-sink balance, modeling of a system of single-rooted leaves without petioles, overview
656977
Amaranthus hybridus subsp. cruentus
pyruvate + CO2 + NADH
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Amaranthus hybridus subsp. cruentus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Amaranthus hybridus subsp. cruentus
Other publictions for EC 1.1.1.38
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721800
Hou
Efficient synthesis of triazol ...
Escherichia coli
Bioorg. Med. Chem. Lett.
21
1667-1669
2011
-
-
-
-
-
-
12
-
-
-
-
1
-
2
-
-
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1
-
1
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1
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1
-
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1
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-
12
-
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-
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1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695884
MacDonald
Mitochondrial malic enzyme (ME ...
Homo sapiens, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
488
100-104
2009
3
-
-
-
-
-
3
-
3
-
-
-
-
3
-
-
-
-
-
7
-
-
3
-
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-
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3
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3
-
-
3
-
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3
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3
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7
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699052
Zheng
Production of L-malic acid wit ...
Brevundimonas diminuta, Brevundimonas diminuta IFO13182
J. Biosci. Bioeng.
107
16-20
2009
-
-
-
-
-
-
-
-
-
-
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-
-
4
-
-
1
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2
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1
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1
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1
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-
2
-
-
-
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-
-
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-
-
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-
-
-
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-
685215
Aktas
Proper positioning of the nico ...
Ascaris suum
Biochemistry
47
2539-2546
2008
-
-
-
-
4
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
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-
-
-
-
1
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1
-
4
-
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-
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1
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-
-
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-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689861
Wang
Over-expression, purification, ...
Escherichia coli K-12
Protein Expr. Purif.
53
97-103
2007
-
-
1
-
-
-
-
2
-
1
3
1
-
4
-
-
1
-
-
-
-
-
1
1
1
-
-
1
1
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
1
3
1
-
-
-
1
-
-
-
-
1
1
1
-
-
1
1
1
-
-
-
-
-
-
-
-
656983
Lara
Induction of a crassulacean ac ...
Portulaca oleracea
Plant Cell Physiol.
45
618-626
2004
-
-
-
-
-
-
1
-
3
1
-
1
-
3
-
-
-
-
-
2
3
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
3
1
-
1
-
-
-
-
-
2
3
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
656977
Sawada
Photosynthesis with single-roo ...
Amaranthus hybridus subsp. cruentus
Plant Cell Physiol.
43
1293-1301
2002
-
-
-
-
-
-
1
-
-
-
-
1
-
3
-
-
-
-
-
1
2
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286680
Viljoen
Mutation of Gly-444 inactivate ...
Schizosaccharomyces pombe
FEMS Microbiol. Lett.
167
157-162
1998
-
-
-
-
1
-
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-
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2
-
2
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3
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1
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1
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1
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3
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-
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-
-
-
-
-
286677
Driscoll
Properties of NAD+ and NADP+-d ...
Sinorhizobium meliloti
Microbiology
143
489-498
1997
1
-
1
-
-
-
4
2
-
5
-
3
-
3
-
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1
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4
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1
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2
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1
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1
2
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4
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2
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5
-
3
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1
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286678
Chooback
Expression, purification, and ...
Ascaris suum
Protein Expr. Purif.
10
51-54
1997
-
-
1
-
-
-
-
4
1
-
-
2
-
3
-
-
1
-
-
-
1
-
3
-
-
-
-
1
-
-
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1
-
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1
1
-
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4
1
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2
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1
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1
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
286679
Srivatava
-
Effect of silver nitrate on ac ...
Mangifera indica
Indian J. Exp. Biol.
34
575-576
1996
-
-
-
-
-
-
1
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2
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1
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3
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1
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1
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1
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3
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286681
Karsten
Stepwise versus concerted oxid ...
Ascaris suum
Biochemistry
33
2096-2103
1994
-
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1
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2
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3
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1
1
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1
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3
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1
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1
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1
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1
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1
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3
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-
286682
Driscoll
NAD+-dependent malic enzyme of ...
Sinorhizobium meliloti
Mol. Microbiol.
7
865-873
1993
-
-
-
-
-
-
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2
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3
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1
1
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3
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1
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1
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2
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1
1
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3
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-
-
286683
Furbank
Regulation of C4 photosynthesi ...
Atriplex spongiosa, Panicum miliaceum, Urochloa panicoides
Arch. Biochem. Biophys.
289
376-381
1991
4
-
-
-
-
-
10
-
-
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-
6
-
6
-
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9
-
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3
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4
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3
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10
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6
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9
-
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286685
Park
pH Dependence of kinetic param ...
Ascaris suum
Biochemistry
25
3752-3759
1986
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3
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3
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2
1
1
5
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1
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1
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2
1
1
5
-
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-
4
-
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-
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-
286684
Rao
Diethylpyrocarbonate inactivat ...
Ascaris suum
Arch. Biochem. Biophys.
241
67-74
1985
-
-
-
-
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1
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2
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2
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1
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286686
Park
Kinetic mechanism in the direc ...
Ascaris suum
Biochemistry
23
5446-5453
1984
-
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2
4
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2
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2
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1
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3
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286687
Kiick
Determination of dissociation ...
Ascaris suum
Biochemistry
23
5454-5459
1984
-
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5
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2
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2
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3
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1
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5
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3
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286688
Cook
Distinct metal cofactor-induce ...
Escherichia coli
Biochim. Biophys. Acta
749
198-203
1983
1
-
-
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-
3
-
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2
-
2
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2
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3
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1
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1
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3
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286689
Yamaguchi
Studies on regulatory function ...
Escherichia coli
J. Biochem.
86
325-333
1979
3
-
-
-
-
-
4
5
-
-
-
4
-
3
-
-
-
-
-
-
2
-
7
-
-
-
-
-
2
-
-
1
-
-
-
3
-
-
1
-
-
-
-
4
-
5
-
-
-
4
-
-
-
-
-
-
2
-
7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286690
Milne
-
Role of metal cofactors in enz ...
Escherichia coli
Biochemistry
18
3605-3610
1979
-
-
-
-
-
-
2
-
-
2
-
2
-
1
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3
-
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1
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1
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1
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2
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2
-
2
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-
3
-
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-
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-
1
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-
-
-
-
-
-
-
-
286691
Rhathnam
-
Studies with isolated bundle s ...
Digitaria sanguinalis, Eleusine indica, Eriochloa borumensis, Megathyrsus maximus, Panicum miliaceum, Zea mays
FEBS Lett.
96
367-372
1978
-
-
-
-
-
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-
12
6
-
-
12
-
6
-
-
-
-
-
-
-
-
18
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
6
-
-
-
-
-
-
12
6
-
-
12
-
-
-
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-
-
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18
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6
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Iwakura
Studies on regulatory function ...
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11
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17
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6
10
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30
-
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-
-
-
-
-
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9
-
-
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6
-
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9
-
-
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5
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8
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11
20
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-
-
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6
10
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30
-
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-
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286693
Landsperger
NAD+-malic enzyme. Regulatory ...
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1
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4
1
1
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2
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3
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-
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-
-
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3
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-
-
-
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1
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1
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1
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4
-
1
1
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2
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-
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-
-
-
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3
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-
-
-
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-
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Studies on the regulatory func ...
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2
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3
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-
-
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3
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1
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2
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1
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4
-
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1
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1
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9
-
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2
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-
-
-
-
-
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3
-
-
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1
-
2
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-
-
-
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-
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286695
Schutz
Das 'Malatenzym' von Lactobaci ...
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3
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6
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3
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2
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2
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9
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2
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2
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3
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6
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2
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2
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9
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286696
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-pfelsäurestoffwechsel bei Sac ...
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2
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1
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2
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1
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1
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1
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3
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1
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2
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1
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2
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2
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1
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2
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1
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1
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3
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-
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-
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1
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286697
Yamaguchi M.; Tokushige
Studies on regulatory function ...
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2
2
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1
1
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1
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1
3
5
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1
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2
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1
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2
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7
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5
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5
2
2
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1
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1
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1
3
5
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1
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Sauer
An NAD- and NADP-dependent mal ...
Rattus norvegicus
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1
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1
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2
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3
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1
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1
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1
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1
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3
1
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2
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2
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3
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Biosynthesis of dicarboxylic a ...
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1
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1
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1
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1
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1
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1
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