1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

malic enzyme, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)

Activating Compound

Activating Compound on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoic acid)
-
0.5 mM, 2.7fold increase in oxaloacetate reduction activity
alpha-methyl-DL-aspartate
-
1.35fold activation
aspartate
ATP
-
68% activation, 2 mM ATP, 0.005 mM CoA, 5 mM malate, 2 mM NAD+, 4 mM Mn2+
beta-methyl-DL-aspartate
-
1.34fold activation
D-Aspartate
-
2 mM, 1.27fold activation
fumarate
L-aspartate
N-ethylmaleimide
-
1 mM, 8.9fold increase in oxaloacetate reduction activity
NH4+
-
30 mM Na+L-malate instead of K+L-malate reduces enzyme activity to 18% in the presence of 3 mM MnCl2, activity is restored with 5 or 50 mM NH4Cl
p-chloromercuribenzoate
-
0.02 mM, 2.5fold increase in oxaloacetate reduction activity
phosphoenolpyruvate
-
0.5 mM
succinate
-
-
UTP
-
35% activation, 2 mM UTP, 0.005 mM CoA, 5 mM malate, 2 mM NAD+, 4 mM Mn2+