1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

malic enzyme, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)

Metals Ions

Metals Ions on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cs+
-
30 mM Na+L-malate instead of K+L-malate reduces enzyme activity to 18% in the presence of 3 mM MnCl2, activity is restored with 5 or 50 mM CsCl
K+
-
30 mM Na+L-malate instead of K+L-malate reduces enzyme activity to 18% in the presence of 3 mM MnCl2, activity is restored with 50 mM KCl
Ni2+
-
requirement for divalent cation
Zn2+
-
requirement for divalent cation