1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

m-NAD(P)-ME, malic enzyme, ME2, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)

KM Value

KM Value on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.42 - 15.6
(S)-malate
0.19 - 50
L-malate
0.12 - 0.32
Mn2+
0.004 - 0.51
NAD+
0.025 - 1.4
NADH
2.3
NADP+
-
-
2.1 - 5
oxaloacetate
additional information
additional information
-
cytosolic NADP+-dependent malic enzyme (c-NADP-ME) is neither a cooperative nor an allosteric enzyme
-