1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH1, D-LDH2, D-LDH3, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, Fermentative lactate dehydrogenase, lactic acid dehydrogenase, LDH, Respiratory D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.28 - D-lactate dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2280
(R)-lactate
Leuconostoc mesenteroides subsp. mesenteroides
-
pH 11.0, 20°C, recombinant enzyme
41 - 175
2-Ketobutyrate
0.056 - 21
2-ketocaproate
0.51
2-Ketoglutarate
Lactobacillus pentosus
-
30°C, pH 5.5, wild-type enzyme
11.1 - 65.7
2-ketoisocaproate
11.7 - 27
2-ketoisovalerate
5.7 - 334
2-Ketovalerate
4.5 - 120
2-oxobutyrate
50 - 270
glyoxylate
8.1 - 407
Hydroxypyruvate
0.64 - 4.42
NAD+
8.28 - 633
NADH
0.48 - 280
oxaloacetate
0.31 - 778
phenylpyruvate
22 - 29000
pyruvate