1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH1, D-LDH2, D-LDH3, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, DLDH744, ECBD_2243, ECLDH, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, LDH, ldhd, LdhTi, Ljd-LDH, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.28 - D-lactate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.15 - 0.25
-
in vivo activity, crude enzyme, cells grown with or without peptone and (NH4)2HPO4, pH 7.3, 42C
2.51
crude enzyme, pyruvate reduction in vivo activity, pH 6.5, 30C
7
-
isozyme D-LDH1, pH 8.0, 25C, substrate D-phenylpyruvate
7.5
purified recombinant enzyme, pH and temperature not specified in the publication
8.3
-
crude enzyme, pyruvate reduction in vivo activity, pH 6.5, 30C
8.78
-
purified recombinant enzyme, D-lactate oxidation, pH 11.0, 20C
9
-
isozyme D-LDH2, pH 8.0, 25C, substrate D-phenylpyruvate
10
-
commercial preparation
13.5
-
pH 8.0, 30C
18
-
isozyme D-LDH3, pH 8.0, 25C, substrate oxaloacetic acid
28
-
isozyme D-LDH3, pH 8.0, 25C, substrate D-phenylpyruvate
30.2
pyruvate reduction, pH 6.0, 70C
41
-
isozyme D-LDH2, pH 8.0, 25C, substrate 2-oxoobutyric acid
41.91
-
isozyme D-LDH3, pH 8.0, 25C, substrate D-lactate
68
-
isozyme D-LDH1, pH 8.0, 25C, substrate 2-oxoobutyric acid
88.71
-
isozyme D-LDH2, pH 8.0, 25C, substrate D-lactate
96.88
-
isozyme D-LDH1, pH 8.0, 25C, substrate D-lactate
116
-
substrate phenylpyruvate, pH 5.5, 45C
140
-
purified recombinant enzyme, substrate phenylpyruvate, pH 5.5, 30C
189
-
isozyme D-LDH3, pH 8.0, 25C, substrate 2-oxoobutyric acid
348
-
isozyme D-LDH3, pH 8.0, 25C, substrate pyruvate
422
-
purified recombinant enzyme, substrate pyruvate, pH 5.5, 30C
835
-
substrate pyruvate, pH 5.5, 45C
1710
-
pH 8.0, 25C
2877
-
isozyme D-LDH2, pH 8.0, 25C, substrate oxaloacetic acid
2997
-
isozyme D-LDH2, pH 8.0, 25C, substrate pyruvate
3151
-
isozyme D-LDH1, pH 8.0, 25C, substrate oxaloacetic acid
3838
-
isozyme D-LDH1, pH 8.0, 25C, substrate pyruvate
4450
-
purified recombinant enzyme, NADH oxidation, pH 8.0, 30C
4990
-
purified recombinant enzyme, pyruvate reduction, pH 8.0, 30C
additional information