1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH1, D-LDH2, D-LDH3, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, DLDH744, ECBD_2243, ECLDH, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, LDH, ldhd, LdhTi, Ljd-LDH, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.28 - D-lactate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
show the reaction diagram
(R)-lactate + NAD+
pyruvate + NADH
show the reaction diagram
(R)-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
2-ketocaproate + NADH
2-hydroxycaproate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketoisocaproate + NADH
2-hydroxyisocaproate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketovalerate + NADH
2-hydroxyvalerate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-4-phenyl-butyric acid + NADH + H+
(R)-2-hydroxy-4-phenyl-butyric acid + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-4-phenylbutyric acid + NADH + H+
(R)-2-hydroxy-4-phenylbutyric acid + NAD+
show the reaction diagram
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxobutyric acid + NADH + H+
(R)-2-hydroxybutyric acid + NAD+
show the reaction diagram
-
-
-
-
ir
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
show the reaction diagram
2-oxoglutarate + NADH + H+
2-hydroxypentanedioate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
show the reaction diagram
2-oxoisovalerate + NADH + H+
2-hydroxyisovalerate + NAD+
show the reaction diagram
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
show the reaction diagram
3,4-dihydroxyphenylpyruvic acid + NADH + H+
(R)-3,4-dihydroxyphenyllactic acid + NAD+
show the reaction diagram
-
-
-
-
?
alpha-ketobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
D-3-phenylpyruvate + NADH + H+
D-3-phenyllactate + NAD+
show the reaction diagram
D-lactate + cytochrome c2ox
pyruvate + cytochrome c2red
show the reaction diagram
-
-
-
-
?
D-lactate + NAD+
pyruvate + NADH
show the reaction diagram
DL-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH
show the reaction diagram
DL-2-hydroxybutyrate + NAD+
? + NADH
show the reaction diagram
-
about 44% of activity against D-lactate
-
-
-
glyoxylate + NADH
hydroxyacetic acid + NAD+
show the reaction diagram
-
-
-
-
?
glyoxylate + NADH + H+
hydroxacetate + NAD+
show the reaction diagram
glyoxylate + NADH + H+
hydroxyacetate + NAD+
show the reaction diagram
glyoxylate + NADH + H+
hydroxyacetic acid + NAD+
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + NADH
glycerate + NAD+
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + NADH + H+
glycerate + NAD+
show the reaction diagram
methylpyruvate + NADH
? + NAD+
show the reaction diagram
oxaloacetate + NADH
malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
D-malate + NAD+
show the reaction diagram
-
-
-
r
oxaloacetate + NADH + H+
malate + NAD+
show the reaction diagram
oxaloacetic acid + NADH + H+
(R)-malate + NAD+
show the reaction diagram
-
-
-
-
ir
phenylpyruvate + NADH
phenyllactate + NAD+
show the reaction diagram
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
show the reaction diagram
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
show the reaction diagram
pyruvate + NAD(P)H + H+
(R)-lactate + NA(P)D+
show the reaction diagram
pyruvate + NADH
(R)-lactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
(R)-lactate + NAD+
show the reaction diagram
additional information
?
-