1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH1, D-LDH2, D-LDH3, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, Fermentative lactate dehydrogenase, lactic acid dehydrogenase, LDH, Respiratory D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Cloned

Cloned on EC 1.1.1.28 - D-lactate dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
construction of a metabolically engineered Saccharomyces cerevisiae that produces D-lactic acid efficiently. Two copies of the D-lactate dehydrogenase gene from Leuconostoc mesenteroides subsp. mesenteroides strain NBRC3426 are introduced into the genome
D-LDH isozymes D-LDH1, D-LDH2, and D-LDH3, sequence comparisons and phylogenetic analysis
-
expression in Escherichia coli
expression in Escherichia coli as thioredoxin fusion protein
-
expression of D-LDH in Escherichia coli strain Rosetta (DE3)
expression of the His6-tagged enzyme in Escherichia coli strain BL21(DE3)
-
gene APE_0487, expression in Escherichia coli strain Rosetta-gami 2 (DE3)
gene ldhA, expression in an enzyme-deficient ldhA-null Corynebacterium glutamicum strain resulting in increased production of D-lactate
gene lhdD or LEUM 1756, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) Star
-
Use of the addressing sequence of yeast D-lactate dehydrogenase for insertion of CYP11A1p into the inner membrane of yeast mitochondria
-