1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH1, D-LDH2, D-LDH3, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, DLDH744, ECBD_2243, ECLDH, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, LDH, ldhd, LdhTi, Ljd-LDH, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

KCat KM Value

KCat KM Value on EC 1.1.1.28 - D-lactate dehydrogenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0073
(R)-lactate
pH 6.5, 30°C, recombinant enzyme
1 - 440
2-oxobutyrate
27 - 87
2-oxocaproate
3.2 - 53
2-oxoisocaproate
35
2-oxoisovalerate
pH 7.0, 30°C, recombinant enzyme
18 - 200
2-oxovalerate
0.7 - 130
glyoxylate
4.2 - 140
Hydroxypyruvate
1.41 - 1.61
NAD+
182.6 - 17000
NADH
21 - 230
oxaloacetate
1 - 7500
phenylpyruvate
1.9 - 7900
pyruvate