1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH1, D-LDH2, D-LDH3, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, DLDH744, ECBD_2243, ECLDH, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, LDH, ldhd, LdhTi, Ljd-LDH, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

KM Value

KM Value on EC 1.1.1.28 - D-lactate dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.59 - 1250
(R)-lactate
0.38 - 20.8
2-Ketobutyrate
1.18 - 189
2-ketocaproate
15.5
2-Ketoglutarate
-
30C, pH 5.5, wild-type enzyme
0.124 - 31
2-ketoisocaproate
5.5 - 18.6
2-ketoisovalerate
0.15 - 17
2-Ketovalerate
0.31 - 58
2-oxobutyrate
2.6 - 5.8
2-oxocaproate
3.8 - 12
2-oxoisocaproate
3.5
2-oxoisovalerate
pH 7.0, 30C, recombinant enzyme
0.68 - 4
2-oxovalerate
4.4 - 10
alpha-Ketobutyrate
0.8
D-lactate
-
pH 8.0, 30C
19
DL-2-Hydroxybutyrate
-
pH 8.0, 25C
5.4 - 100
glyoxylate
0.28 - 53
Hydroxypyruvate
0.00044 - 2.9
NAD+
0.00021 - 2.83
NADH
0.0035
NADPH
-
-
1.7 - 54
oxaloacetate
0.03 - 22
phenylpyruvate
0.07 - 31
pyruvate
additional information
additional information
-