1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, Hsd11B2, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

KM Value

KM Value on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.075
1,2-dehydrocortisol
-
-
-
0.00025 - 0.0073
11-Dehydrocorticosterone
0.0014 - 0.027
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione
0.000034 - 0.0195
11beta,21-dihydroxypregn-4-en-3,20-dione
0.0169
11beta-hydroxyprogesterone
-
-
0.000056
11beta-hydroxytestosterone
-
pH 7.4, 37C, microsomal assay
0.204
16alpha-methyl-1,2-dehydrocortisol
-
-
0.0487
16alpha-Methylcortisol
-
-
0.0038 - 0.0095
17,21-dihydroxy-pregn-4-ene-3,11,20-trione
0.02
2,3-benzoylphenyl-propanoic acid
-
microsomal fraction from transformed Pichia pastoris strain with human enzyme
0.79
2-amino-8-((2,6-difluorobenzyl)thio)-1,9-dihydro-6H-purin-6-one
-
37C, pH 10.8-11.0
0.00144 - 0.00283
21-hydroxy-pregn-4-en-3,11,20-trione
0.581 - 0.961
5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulphonyl)phenyl-2-(5H-furanone)-lactol
0.0012
5alpha-androstane-3beta,7alpha,17beta-triol
-
pH 7.4, 28C
0.021
5alpha-androstane-3beta,7beta,17beta-triol
-
pH 7.4, 28C
0.0051 - 0.0068
7-oxo-5alpha-androstane-3beta,17beta-diol
0.00038 - 0.00049
7-oxocholesterol
0.00049
7alpha-hydroxycholesterol
37C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
0.00073 - 0.00075
7beta-hydroxycholesterol
0.0003 - 0.043
corticosterone
0.000237 - 0.1
cortisol
0.00028 - 0.1
cortisone
0.02
dehydrocorticosterone
-
37C, pH 7.4, Hill coefficient of 2.7
0.37
metapyrone
-
microsomal fraction from transformed Pichia pastoris strain with human enzyme
0.0000102 - 0.091
NAD+
0.0000063 - 0.00427
NADP+
0.00355 - 0.00372
NADPH
0.042
oracin
-
-
additional information
additional information
-