1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, Hsd11B2, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

KI Value

KI Value on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000064
(+/-)-2-((cyclohexylmethyl)amino)-5-ethyl-5-methyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000034
(+/-)-2-((cyclohexylmethyl)amino)-5-methyl-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000024
(+/-)-2-(1-adamantylamino)-5-ethyl-5-methyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000024
(+/-)-2-(1-adamantylamino)-5-methyl-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000082
(+/-)-2-(cycloheptylamino)-5-ethyl-5-methyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000032
(+/-)-2-(cycloheptylamino)-5-methyl-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000126
(+/-)-2-(cyclohexylamino)-5-ethyl-5-methyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000055
(+/-)-2-(cyclohexylamino)-5-methyl-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000047
(+/-)-2-(cyclooctylamino)-5-ethyl-5-methyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000028
(+/-)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000073
(+/-)-5-ethyl-5-methyl-2-(1-norbornylamino)-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000013
(+/-)-5-ethyl-5-methyl-2-(3-noradamantylamino)-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000372
(+/-)-5-ethyl-5-methyl-2-(7-norbornylamino)-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000058
(+/-)-5-ethyl-5-methyl-2-[(2,2,3,3-tetramethylcyclopropyl)amino]-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000025
(+/-)-5-methyl-2-(1-norbornylamino)-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000012
(+/-)-5-methyl-2-(3-noradamantylamino)-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000149
(+/-)-5-methyl-2-(7-norbornylamino)-5-propyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000038
(+/-)-5-methyl-5-propyl-2-[(2,2,3,3-tetramethylcyclopropyl)amino]-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.0000472
(R)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.00077
(R)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.0000306
(R)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000329
(R)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.0000278
(S)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000227
(S)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.0000128
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000012
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000028
2-(1-adamantylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one
-
pH and temperature not specified in the publication
0.00002
2-(1-adamantylamino)-5,5-diethyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.000003
2-(3-noradamantylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one
-
pH and temperature not specified in the publication
0.000287
2-(6-[[(3-chloro-2-methylphenyl)sulfonyl]amino]pyridin-2-yl)-N,N-diethylacetamide
-
pH not specified in the publication, temperature not specified in the publication
0.000058
2-(bicyclo[2.2.1]hept-2-ylamino)-5-(propan-2-yl)-1,3-thiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000014
2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one
-
pH and temperature not specified in the publication
0.000026
2-(cyclooctylamino)-5,5-diethyl-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.0000173
2-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(propan-2-yl)-1,3-thiazol-4(5H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.000169
3-chloro-2-methyl-N-(6-methylpyridin-2-yl)benzenesulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000169
3-chloro-2-methyl-N-[6-[2-oxo-2-(piperidin-1-yl)ethyl]pyridin-2-yl]benzenesulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000058
4'-chloro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000019
4'-cyano-N-(6-cyclopropylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000066
4'-cyano-N-(6-ethylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000004
4'-cyano-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000048
4'-cyano-N-[6-(ethylamino)pyridin-2-yl]biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000098
4'-cyano-N-[6-(methylamino)pyridin-2-yl]biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.0000017
4'-cyano-N-[6-(propan-2-yl)pyridin-2-yl]biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.00002
4'-fluoro-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000062
4'-methyl-N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000013
5,5-diethyl-2-(3-noradamantylamino)-1,3-thiazol-4-(5H)-one
-
pH and temperature not specified in the publication
0.00005 - 0.003
arylsulfoamidothiazole
0.0016
fenofibrate
-
82% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0091
fenofibric acid cyclohexyl ester
-
54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0034
fenofibric acid ethylester
-
85% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0031
fenofibric acid isobutylester
-
75% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.009
fenofibric acid isopropyl amide
-
54% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0041
fenofibric acid n-butylester
-
64% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, temperature not specified in the publication
0.0000049 - 0.000014
glycyrrhetinic acid
0.000108
N-(6-methylpyridin-2-yl)-4-(trifluoromethyl)benzenesulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000048
N-(6-methylpyridin-2-yl)biphenyl-4-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
0.000084
N-(6-methylpyridin-2-yl)naphthalene-2-sulfonamide
-
pH not specified in the publication, temperature not specified in the publication
additional information
N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide
-
Ki below 0.000001 mM, pH not specified in the publication, temperature not specified in the publication