Reference on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hult, M.; Nobel, C.S.I.; Abrahmsen, L.; Nicoll-Griffith, D.A.; Jörnvall, H.; Oppermann, U.C.T.
Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1
Chem. Biol. Interact.
130-132
805-8014
2001
Homo sapiens
Manually annotated by BRENDA team
Walker, E.A.; Clarks, A.M.; Hewison, M.; Ride, J.P.; Steward, P.M.
Functional expression, characterization, and purification of the catalytic domain of human 11-beta-hydroxysteroid dehydrogenase type 1
J. Biol. Chem.
276
21343-21350
2001
Homo sapiens
Manually annotated by BRENDA team
Oppermann, U.C.T.; Persson, B.; Jornvall, H.
The 11beta-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action
Eur. J. Biochem.
249
355-360
1997
Comamonas testosteroni, Homo sapiens, Mus musculus, Oryctolagus cuniculus
-
Manually annotated by BRENDA team
Latif, S.A.; Sheff, M.F.; Ribeiro, C.E.; Morris, D.J.
Selective inhibition of sheep kidney 11beta-hydroxysteroid dehydrogenase isoform 2 activity by 5alpha-reduced (but not 5beta) derivates of adrenocorticosteroids
Steroids
62
230-237
1997
Rattus sp.
Manually annotated by BRENDA team
Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.
Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform
Am. J. Physiol.
270
E900-904
1996
Homo sapiens
Manually annotated by BRENDA team
Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.
Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron
Biochim. Biophys. Acta
1243
461-468
1995
Rattus norvegicus
Manually annotated by BRENDA team
Blum , S.; Buhler, H.
Characterization of human placental 11beta-hydroxysteroid dehydrogenase, a key enzyme of cortocosteroid metabolism
Cell. Physiol. Biochem.
5
167-175
1995
Homo sapiens
-
Manually annotated by BRENDA team
Ozols, J.
Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase
J. Biol. Chem.
270
2305-2312
1995
Oryctolagus cuniculus
Manually annotated by BRENDA team
Lakshim, V.; Nath, N.; Muneyyirci-Delale, O.
Characterization of 11beta-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11beta-hydroxysteroid dehydrogenases
J. Steroid Biochem. Mol. Biol.
45
391-397
1993
Homo sapiens
Manually annotated by BRENDA team
Monder, C.
The forms and functions of 11beta-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
45
161-165
1993
Rattus norvegicus
Manually annotated by BRENDA team
Hundertmark, S.; Ragosch, V.; Schein, B.; Buhler, H.; Fromm, M.; Lorenz, U.; Weitzel, H.K.
11-beta-Hydroxysteroid dehydrogenase of rat lung: Enzyme kinetic, oxidase-reductase ration, electrolyte and trace element dependence
Enzyme Protein
47
83-91
1993
Rattus norvegicus, Rattus sp.
Manually annotated by BRENDA team
Buhler, H.; Perschel, F.H.; Hierholzer, K.
Inhibition of rat renal 11beta-hydroxysteroid dehydrogenase by steroidal compounds and triterpenoids; structure/function relationship
Biochim. Biophys. Acta
1075
206-212
1991
Rattus sp.
Manually annotated by BRENDA team
Sang, G.W.; Lorenzo, B.; Reidenberg, M.M.
Inhibitory effects of gossypol on corticosteroid 11beta-hydroxysteroid dehydrogenase from guinea pig kidney: A possible mechanism for causing hypokalemia
J. Steroid Biochem. Mol. Biol.
39
169-176
1991
Cavia porcellus
Manually annotated by BRENDA team
Monder, C.; Lakshmi, V.; Miroff, Y.
Kinetic studies on rat liver 11beta-hydroxysteroid dehydrogenase
Biochim. Biophys. Acta
1115
23-29
1991
Rattus sp.
Manually annotated by BRENDA team
Agarwal, A.K.; Tusie-Luna, M.T.; Monder, C.; White, P.C.
Expression of 11beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus
Mol. Endocrinol.
4
1827-1832
1990
Rattus sp.
Manually annotated by BRENDA team
Monder, C.; Lakshmi, V.
Evidence for kinetically distinct forms of corticosteroid 11beta-dehydrogenase in rat liver microsomes
J. Steroid Biochem.
32
77-83
1989
Rattus sp.
Manually annotated by BRENDA team
Monder, C.; Lakshmi, V.
Corticosteroid 11beta-hydroxysteroid dehydrogenase activities in vertebrate liver
Steroids
52
515-528
1988
aves, dogfish, Mammalia, no activity in frog, no activity in Necturus maculosus, no activity in shark, no activity in toad, Rattus sp.
Manually annotated by BRENDA team
Lakshmi, V.; Monder, C.
Purification and characterization of the corticosteroid 11beta-dehydrogenase component of the rat liver 11beta-hydroxysteroid dehydrogenase complex
Endocrinology
123
2390-2398
1988
Rattus sp.
Manually annotated by BRENDA team
Pearson Murphy, B.E.
Specificity of human 11beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
14
807-809
1981
Homo sapiens
Manually annotated by BRENDA team
Bush, I.E.; Hunter, S.A.; Meigs, R.A.
Metabolism of 11-oxogenated steroids. Metabolism in vitro by preparations of liver
Biochem. J.
107
239-258
1968
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus, Rattus sp.
Manually annotated by BRENDA team
Gomez-Sanchez, E.P.; Ganjam, V.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol.
285
E272-279
2003
Rattus norvegicus
Manually annotated by BRENDA team
Holmes, M.C.; Yau, J.L.W.; Kotelevtsev, Y.; Mullins, J.J.; Seckl, J.R.
11beta-Hydroxysteroid dehydrogenases in the brain: two enzymes two roles
Ann. N. Y. Acad. Sci.
1007
357-366
2003
Mus musculus
Manually annotated by BRENDA team
Maser, E.; Volker, B.; Friebertshauser, J.
11 beta-Hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase
Biochemistry
41
2459-2465
2002
Homo sapiens
Manually annotated by BRENDA team
Blum, A.; Raum, A.; Maser, E.
Functional characterization of the human 11 beta-hydroxysteroid dehydrogenase 1B (11 beta-HSD 1B) variant
Biochemistry
42
4108-4117
2003
Homo sapiens
Manually annotated by BRENDA team
Schipper, L.; Spee, B.; Rothuizen, J.; Woutersen-van Nijnanten, F.; Fink-Gremmels, J.
Characterisation of 11beta-hydroxysteroid dehydrogenases in feline kidney and liver
Biochim. Biophys. Acta
1688
68-77
2004
Felis catus
Manually annotated by BRENDA team
Zbankova, S.; Bryndova, J.; Kment, M.; Pacha, J.
Expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in colorectal cancer
Cancer Lett.
210
95-100
2004
Homo sapiens
Manually annotated by BRENDA team
Maser, E.; Friebertshauser, J.; Volker, B.
Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen
Chem. Biol. Interact.
143-144
435-448
2003
Homo sapiens
Manually annotated by BRENDA team
Wsol, V.; Szotakova, B.; Skalova, L.; Maser, E.
Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1
Chem. Biol. Interact.
143-144
459-468
2003
Mus musculus
Manually annotated by BRENDA team
Blum, A.; Maser, E.
The critical role of the N-terminus of 11beta-hydroxysteroid dehydrogenase type 1, as being encoded by exon 1, for enzyme stabilization and activity
Chem. Biol. Interact.
143-144
469-480
2003
Homo sapiens
Manually annotated by BRENDA team
Wang, G.M.; Ge, R.S.; Latif, S.A.; Morris, D.J.; Hardy, M.P.
Expression of 11beta-hydroxylase in rat Leydig cells
Endocrinology
143
621-626
2002
Rattus norvegicus
Manually annotated by BRENDA team
Waddell, B.J.; Hisheh, S.; Krozowski, Z.S.; Burton, P.J.
Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract
Endocrinology
144
3101-3106
2003
Rattus norvegicus
Manually annotated by BRENDA team
Shafqat, N.; Elleby, B.; Svensson, S.; Shafqat, J.; Jornvall, H.; Abrahmsen, L.; Oppermann, U.
Comparative enzymology of 11beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (guinea pig) versus sensitive (human) species
J. Biol. Chem.
278
2030-2035
2003
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Schweizer, R.A.; Zurcher, M.; Balazs, Z.; Dick, B.; Odermatt, A.
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme
J. Biol. Chem.
279
18415-18424
2004
Homo sapiens, Mesocricetus auratus (Q6R0J2), Rattus norvegicus
Manually annotated by BRENDA team
Frick, C.; Atanasov, A.G.; Arnold, P.; Ozols, J.; Odermatt, A.
Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase
J. Biol. Chem.
279
31131-31138
2004
Homo sapiens
Manually annotated by BRENDA team
Roobol-Boza, M.; Dolby, V.; Doverskog, M.; Barrefelt, A.; Lindqvist, F.; Oppermann, U.C.; Kohler Van Alstine, K.; Tjerneld, F.
Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems. Purification of the human type 1 11beta-hydroxysteroid dehydrogenase
J. Chromatogr. A
1043
217-223
2004
Homo sapiens
Manually annotated by BRENDA team
Nobel, C.S.I.; Dunas, F.; Abrahmsen, L.B.
Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities
Protein Expr. Purif.
26
349-356
2002
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Wsol, V.; Szotakova, B.; Skalova, L.; Maser, E.
The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1
Toxicology
197
253-261
2004
Homo sapiens
Manually annotated by BRENDA team
Gomez-Sanchez, E.P.; Venkataseshu, G.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol. Endocrinol. Metab.
285
E272-E279
2003
Rattus norvegicus
Manually annotated by BRENDA team
Garbrecht, M.R.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
11beta-Hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites
Am. J. Physiol. Endocrinol. Metab.
290
E653-E660
2006
Homo sapiens
Manually annotated by BRENDA team
Zhang, J.; Osslund, T.D.; Plant, M.H.; Clogston, C.L.; Nybo, R.E.; Xiong, F.; Delaney, J.M.; Jordan, S.R.
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes
Biochemistry
44
6948-6957
2005
Mus musculus, Mus musculus (P50172)
Manually annotated by BRENDA team
Kim, K.W.; Wang, Z.; Busby, J.; Tsuruda, T.; Chen, M.; Hale, C.; Castro, V.M.; Svensson, S.; Nybo, R.; Xiong, F.; Wang, M.
The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate
Biochim. Biophys. Acta
1764
824-830
2006
Homo sapiens
Manually annotated by BRENDA team
Xiang, J.; Ipek, M.; Suri, V.; Massefski, W.; Pan, N.; Ge, Y.; Tam, M.; Xing, Y.; Tobin, J.F.; Xu, X.; Tam, S.
Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
15
2865-2869
2005
Homo sapiens
Manually annotated by BRENDA team
Olson, S.; Aster, S.D.; Brown, K.; Carbin, L.; Graham, D.W.; Hermanowski-Vosatka, A.; LeGrand, C.B.; Mundt, S.S.; Robbins, M.A.; Schaeffer, J.M.; Slossberg, L.H.; Szymonifka, M.J.; Thieringer, R.; Wright, S.D.; Balkovec, J.M.
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
15
4359-4362
2005
Homo sapiens, Mus musculus (P50172), Mus musculus (P51661)
Manually annotated by BRENDA team
Cherkasova, O.P.
Activity of 11beta-hydroxysteroid dehydrogenase in tissues of hypertensive NISAG rats
Bull. Exp. Biol. Med.
141
30-32
2006
Rattus norvegicus
Manually annotated by BRENDA team
Mai, K.; Kullmann, V.; Bobbert, T.; Maser-Gluth, C.; Moehlig, M.; Baehr, V.; Pfeiffer, A.F.; Spranger, J.; Diederich, S.
In vivo activity of 11beta-hydroxysteroid dehydrogenase type 1 and free fatty acid-induced insulin resistance
Clin. Endocrinol. (Oxf.)
63
442-449
2005
Homo sapiens
Manually annotated by BRENDA team
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Alford, F.P.; Inder, W.J.
11beta Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle
Clin. Endocrinol. (Oxf.)
65
800-805
2006
Homo sapiens
Manually annotated by BRENDA team
Basu, R.; Edgerton, D.S.; Singh, R.J.; Cherrington, A.; Rizza, R.A.
Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity
Diabetes
55
3013-3019
2006
Canis lupus familiaris
Manually annotated by BRENDA team
Li, W.; Gao, L.; Wang, Y.; Duan, T.; Myatt, L.; Sun, K.
Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells
Endocrinology
147
2490-2495
2006
Homo sapiens
Manually annotated by BRENDA team
Ohshima, M.; Ohno, S.; Nakajin, S.
Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands
Environ. Sci.
12
219-230
2005
Homo sapiens
Manually annotated by BRENDA team
Claus, R.; Wagner, A.; Lambert, T.
Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis
Exp. Clin. Endocrinol. Diabetes
113
262-267
2005
Sus scrofa (Q95L61)
Manually annotated by BRENDA team
Atanasov, A.G.; Dzyakanchuk, A.A.; Schweizer, R.A.; Nashev, L.G.; Maurer, E.M.; Odermatt, A.
Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee?
FEBS Lett.
580
4081-4085
2006
Homo sapiens
Manually annotated by BRENDA team
Ogg, D.; Elleby, B.; Norstroem, C.; Stefansson, K.; Abrahmsen, L.; Oppermann, U.; Svensson, S.
The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
J. Biol. Chem.
280
3789-3794
2005
Cavia porcellus, Cavia porcellus (Q6QLL4)
Manually annotated by BRENDA team
Hosfield, D.J.; Wu, Y.; Skene, R.J.; Hilgers, M.; Jennings, A.; Snell, G.P.; Aertgeerts, K.
Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation
J. Biol. Chem.
280
4639-4648
2005
Homo sapiens
Manually annotated by BRENDA team
McCormick, K.L.; Wang, X.; Mick, G.J.
Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes
J. Biol. Chem.
281
341-347
2006
Rattus norvegicus
Manually annotated by BRENDA team
Miguet, L.; Zhang, Z.; Barbier, M.; Grigorov, M.G.
Comparison of a homology model and the crystallographic structure of human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) in a structure-based identification of inhibitors
J. Comput. Aided Mol. Des.
20
67-81
2006
Homo sapiens
Manually annotated by BRENDA team
Gilmour, J.S.; Coutinho, A.E.; Cailhier, J.F.; Man, T.Y.; Clay, M.; Thomas, G.; Harris, H.J.; Mullins, J.J.; Seckl, J.R.; Savill, J.S.; Chapman, K.E.
Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
J. Immunol.
176
7605-7611
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Mazancova, K.; Kopecky, M.; Miksik, I.; Pacha, J.
11beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats
J. Steroid Biochem. Mol. Biol.
94
273-277
2005
Rattus norvegicus
Manually annotated by BRENDA team
Ayachi, S.E.; Paulmyer-Lacroix, O.; Verdier, M.; Alessi, M.C.; Dutour, A.; Grino, M.
11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women
J. Thromb. Haemost.
4
621-627
2006
Homo sapiens
Manually annotated by BRENDA team
Latif, S.A.; Pardo, H.A.; Hardy, M.P.; Morris, D.J.
Endogenous selective inhibitors of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin
Mol. Cell. Endocrinol.
243
43-50
2005
Homo sapiens, Ovis aries
Manually annotated by BRENDA team
Odermatt, A.; Atanasov, A.G.; Balazs, Z.; Schweizer, R.A.; Nashev, L.G.; Schuster, D.; Langer, T.
Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1
Mol. Cell. Endocrinol.
248
15-23
2006
Homo sapiens (P28845)
Manually annotated by BRENDA team
Su, X.; Vicker, N.; Ganeshapillai, D.; Smith, A.; Purohit, A.; Reed, M.J.; Potter, B.V.
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
214-217
2006
Homo sapiens
Manually annotated by BRENDA team
Czegle, I.; Piccirella, S.; Senesi, S.; Csala, M.; Mandl, J.; Banhegyi, G.; Fulceri, R.; Benedetti, A.
Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
Mol. Cell. Endocrinol.
248
24-25
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hult, M.; Shafqat, N.; Elleby, B.; Mitschke, D.; Svensson, S.; Forsgren, M.; Barf, T.; Vallgarda, J.; Abrahmsen, L.; Oppermann, U.
Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons
Mol. Cell. Endocrinol.
248
26-33
2006
Cavia porcellus, Homo sapiens, Homo sapiens (P28845), Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Maser, E.; Wsol, V.; Martin, H.J.
11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics
Mol. Cell. Endocrinol.
248
34-37
2006
Homo sapiens
Manually annotated by BRENDA team
Arai, N.; Masuzaki, H.; Tanaka, T.; Ishii, T.; Yasue, S.; Kobayashi, N.; Tomita, T.; Noguchi, M.; Kusakabe, T.; Fujikura, J.; Ebihara, K.; Hirata, M.; Hosoda, K.; Hayashi, T.; Sawai, H.; Minokoshi, Y.; Nakao, K.
Ceramide and adenosine 5-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes
Endocrinology
148
5268-5277
2007
Mus musculus
Manually annotated by BRENDA team
De Sousa Peixoto, R.A.; Turban, S.; Battle, J.H.; Chapman, K.E.; Seckl, J.R.; Morton, N.M.
Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo
Endocrinology
149
1861-1868
2008
Mus musculus
Manually annotated by BRENDA team
Gomez-Sanchez, E.P.; Romero, D.G.; de Rodriguez, A.F.; Warden, M.P.; Krozowski, Z.; Gomez-Sanchez, C.E.
Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat
Endocrinology
149
525-533
2008
Rattus norvegicus
Manually annotated by BRENDA team
Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Rohner-Jeanrenaud, F.; Odermatt, A.
DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
J. Am. Soc. Nephrol.
19
92-101
2008
Rattus norvegicus
Manually annotated by BRENDA team
Ito-Kobayashi, M.; Aoyagi, A.; Tanaka, I.; Muramatsu, Y.; Umetani, M.; Takatsu, T.
Sterenin A, B, C and D, novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors from Stereum sp. SANK 21205
J. Antibiot.
61
128-135
2008
Homo sapiens
Manually annotated by BRENDA team
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Krozowski, Z.; Inder, W.J.; Alford, F.P.
Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
J. Clin. Endocrinol. Metab.
92
3314-3320
2007
Homo sapiens
Manually annotated by BRENDA team
Sloboda, D.M.; Moss, T.J.; Li, S.; Matthews, S.G.; Challis, J.R.; Newnham, J.P.
Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
J. Endocrinol.
197
213-220
2008
Ovis aries
Manually annotated by BRENDA team
Perrone, C.E.; Mattocks, D.A.; Hristopoulos, G.; Plummer, J.D.; Krajcik, R.A.; Orentreich, N.
Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue
J. Lipid Res.
49
12-23
2008
Rattus norvegicus
Manually annotated by BRENDA team
Sinclair, A.J.; Onyimba, C.U.; Khosla, P.; Vijapurapu, N.; Tomlinson, J.W.; Burdon, M.A.; Stewart, P.M.; Murray, P.I.; Walker, E.A.; Rauz, S.
Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus
J. Neuroendocrinol.
19
614-620
2007
Oryctolagus cuniculus
Manually annotated by BRENDA team
Gong, R.; Morris, D.J.; Brem, A.S.
Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2
Life Sci.
82
631-637
2008
Homo sapiens
Manually annotated by BRENDA team
Sun, L.; Stenken, J.A.; Yang, A.Y.; Zhao, J.J.; Musson, D.G.
An in vitro microdialysis methodology to study 11beta-hydroxysteroid dehydrogenase type 1 enzyme activity in liver microsomes
Anal. Biochem.
370
26-37
2007
Canis lupus, Homo sapiens
Manually annotated by BRENDA team
Bhat, B.G.; Younis, H.; Herrera, J.; Palacio, K.; Pascual, B.; Hur, G.; Jessen, B.; Ogilvie, K.M.; Rejto, P.A.
Antisense inhibition of 11betahydroxysteroid dehydrogenase type 1 improves diabetes in a novel cortisone-induced diabetic KK mouse model
Biochem. Biophys. Res. Commun.
365
740-745
2008
Mus musculus
Manually annotated by BRENDA team
Flyren, K.; Bergquist, L.O.; Castro, V.M.; Fotsch, C.; Johansson, L.; St Jean, D.J.; Sutin, L.; Williams, M.
Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Bioorg. Med. Chem. Lett.
17
3421-3425
2007
Homo sapiens
Manually annotated by BRENDA team
Yang, H.; Dou, W.; Lou, J.; Leng, Y.; Shen, J.
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling
Bioorg. Med. Chem. Lett.
18
1340-1345
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Aster, S.D.; Graham, D.W.; Kharbanda, D.; Patel, G.; Ponpipom, M.; Santorelli, G.M.; Szymonifka, M.J.; Mundt, S.S.; Shah, K.; Springer, M.S.; Thieringer, R.; Hermanowski-Vosatka, A.; Wright, S.D.; Xiao, J.; Zokian, H.; Balkovec, J.M.
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
18
2799-2804
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wang, H.; Ruan, Z.; Li, J.J.; Simpkins, L.M.; Smirk, R.A.; Wu, S.C.; Hutchins, R.D.; Nirschl, D.S.; Van Kirk, K.; Cooper, C.B.; Sutton, J.C.; Ma, Z.; Golla, R.; Seethala, R.; Salyan, M.E.; Nayeem, A.; Krystek, S.R.; Sheriff, S.; Camac, D.M.; Morin, P.E.; Carpenter, B.; Robl, J.A.; Zahler, R.; Gordon, D.A.; Hamann, L.G.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
18
3168-3172
2008
Homo sapiens
Manually annotated by BRENDA team
Zhu, Y.; Olson, S.H.; Hermanowski-Vosatka, A.; Mundt, S.; Shah, K.; Springer, M.; Thieringer, R.; Wright, S.; Xiao, J.; Zokian, H.; Balkovec, J.M.
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
18
3405-3411
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhu, Y.; Olson, S.H.; Graham, D.; Patel, G.; Hermanowski-Vosatka, A.; Mundt, S.; Shah, K.; Springer, M.; Thieringer, R.; Wright, S.; Xiao, J.; Zokian, H.; Dragovic, J.; Balkovec, J.M.
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
18
3412-3416
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sun, D.; Wang, Z.; Di, Y.; Jaen, J.C.; Labelle, M.; Ma, J.; Miao, S.; Sudom, A.; Tang, L.; Tomooka, C.S.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
18
3513-3516
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ahmed, A.; Saksena, S.; Sherlock, M.; Olliff, S.P.; Elias, E.; Stewart, P.M.
Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease
Clin. Endocrinol. (Oxf.)
68
898-903
2008
Homo sapiens
Manually annotated by BRENDA team
Marcolongo, P.; Piccirella, S.; Senesi, S.; Wunderlich, L.; Gerin, I.; Mandl, J.; Fulceri, R.; Banhegyi, G.; Benedetti, A.
The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue
Endocrinology
148
2487-2495
2007
Rattus norvegicus
Manually annotated by BRENDA team
Kim, K.W.; Wang, Z.; Busby, J.; Tsuruda, T.; Chen, M.; Hale, C.; Castro, V.M.; Svensson, S.; Nybo, R.; Xiong, F.; Wang, M.
The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding
FEBS Lett.
581
995-999
2007
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Kim, J.; Temple, K.A.; Jones, S.A.; Meredith, K.N.; Basko, J.L.; Brady, M.J.
Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels
J. Biol. Chem.
282
11038-11046
2007
Mus musculus
Manually annotated by BRENDA team
Walker, E.A.; Ahmed, A.; Lavery, G.G.; Tomlinson, J.W.; Kim, S.Y.; Cooper, M.S.; Ride, J.P.; Hughes, B.A.; Shackleton, C.H.; McKiernan, P.; Elias, E.; Chou, J.Y.; Stewart, P.M.
11beta-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function
J. Biol. Chem.
282
27030-27036
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bujalska, I.J.; Durrani, O.M.; Abbott, J.; Onyimba, C.U.; Khosla, P.; Moosavi, A.H.; Reuser, T.T.; Stewart, P.M.; Tomlinson, J.W.; Walker, E.A.; Rauz, S.
Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
J. Endocrinol.
192
279-288
2007
Homo sapiens
Manually annotated by BRENDA team
Johansson, L.; Fotsch, C.; Bartberger, M.D.; Castro, V.M.; Chen, M.; Emery, M.; Gustafsson, S.; Hale, C.; Hickman, D.; Homan, E.; Jordan, S.R.; Komorowski, R.; Li, A.; McRae, K.; Moniz, G.; Matsumoto, G.; Orihuela, C.; Palm, G.; Veniant, M.; Wang, M.; Williams, M.; Zhang, J.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
J. Med. Chem.
51
2933-2943
2008
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Julian, L.D.; Wang, Z.; Bostick, T.; Caille, S.; Choi, R.; Degraffenreid, M.; Di, Y.; He, X.; Hungate, R.W.; Jaen, J.C.; Liu, J.; Monshouwer, M.; McMinn, D.; Rew, Y.; Sudom, A.; Sun, D.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model
J. Med. Chem.
51
3953-3960
2008
Homo sapiens, Homo sapiens (P28845), Macaca fascicularis
Manually annotated by BRENDA team
London, E.; Lala, G.; Berger, R.; Panzenbeck, A.; Kohli, A.A.; Renner, M.; Jackson, A.; Raynor, T.; Loya, K.; Castonguay, T.W.
Sucrose access differentially modifies 11beta-hydroxysteroid dehydrogenase-1 and hexose-6-phosphate dehydrogenase message in liver and adipose tissue in rats
J. Nutr.
137
2616-2621
2007
Rattus norvegicus
Manually annotated by BRENDA team
Klusonova, P.; Kucka, M.; Ergang, P.; Miksik, I.; Bryndova, J.; Pacha, J.
Cloning of chicken 11beta-hydroxysteroid dehydrogenase type 1 and its tissue distribution
J. Steroid Biochem. Mol. Biol.
111
217-224
2008
Gallus gallus
Manually annotated by BRENDA team
Sakumoto, R.; Ito, S.; Okuda, K.
Changes in expression of 11beta-hydroxysteroid dehydrogenase type-1, type-2 and glucocorticoid receptor mRNAs in porcine corpus luteum during the estrous cycle
Mol. Reprod. Dev.
75
925-930
2008
Sus scrofa
Manually annotated by BRENDA team
Munoz, R.; Carvajal, C.; Escalona, A.; Boza, C.; Perez, G.; Ibanez, L.; Fardella, C.
11beta-Hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients
Obes. Surg.
19
764-770
2008
Homo sapiens
Manually annotated by BRENDA team
Nashev, L.G.; Chandsawangbhuwana, C.; Balazs, Z.; Atanasov, A.G.; Dick, B.; Frey, F.J.; Baker, M.E.; Odermatt, A.
Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids
PLoS ONE
2
0000
2007
Homo sapiens
-
Manually annotated by BRENDA team
Sunak, N.; Green, D.F.; Abeydeera, L.R.; Thurston, L.M.; Michael, A.E.
Implication of cortisol and 11beta -hydroxysteroid dehydrogenase enzymes in the development of porcine (Sus scrofa domestica) ovarian follicles and cysts
Reproduction
133
1149-1158
2007
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
11Beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology
Reproduction
134
473-482
2007
Sus scrofa
Manually annotated by BRENDA team
Hennebert, O.; Le Mee, S.; Pernelle, C.; Morfin, R.
5Alpha-androstane-3beta,7alpha,17beta-triol and 5alpha-androstane-3beta,7beta,17beta-triol as substrates for the human 11beta-hydroxysteroid dehydrogenase type 1
Steroids
72
855-864
2007
Homo sapiens
Manually annotated by BRENDA team
Czegle, I.; Margittai, E.; Senesi, S.; Benedetti, A.; Banhegyi, G.
Different expression and distribution of 11beta-hydroxysteroid dehydrogenase type 1 in obese and lean animal models of type 2 diabetes
Acta Physiol. Hung.
95
419-424
2008
Rattus norvegicus
Manually annotated by BRENDA team
Hong, D.; Li, X.W.; Lian, Q.Q.; Lamba, P.; Bernard, D.J.; Hardy, D.O.; Chen, H.X.; Ge, R.S.
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells
Biochem. Biophys. Res. Commun.
389
305-309
2009
Mus musculus
Manually annotated by BRENDA team
Lee, H.Y.; Acosta, T.J.; Skarzynski, D.J.; Okuda, K.
Prostaglandin F2alpha stimulates 11beta-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells
Biol. Reprod.
80
657-664
2009
Bos taurus
Manually annotated by BRENDA team
Rew, Y.; McMinn, D.L.; Wang, Z.; He, X.; Hungate, R.W.; Jaen, J.C.; Sudom, A.; Sun, D.; Tu, H.; Ursu, S.; Villemure, E.; Walker, N.P.; Yan, X.; Ye, Q.; Powers, J.P.
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors
Bioorg. Med. Chem. Lett.
19
1797-1801
2009
Homo sapiens (P28845)
Manually annotated by BRENDA team
Roche, D.; Carniato, D.; Leriche, C.; Lepifre, F.; Christmann-Franck, S.; Graedler, U.; Charon, C.; Bozec, S.; Doare, L.; Schmidlin, F.; Lecomte, M.; Valeur, E.
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
19
2674-2678
2009
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Lepifre, F.; Christmann-Franck, S.; Roche, D.; Leriche, C.; Carniato, D.; Charon, C.; Bozec, S.; Doare, L.; Schmidlin, F.; Lecomte, M.; Valeur, E.
Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold
Bioorg. Med. Chem. Lett.
19
3682-3685
2009
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Tu, H.; Powers, J.P.; Liu, J.; Ursu, S.; Sudom, A.; Yan, X.; Xu, H.; Meininger, D.; Degraffenreid, M.; He, X.; Jaen, J.C.; Sun, D.; Labelle, M.; Yamamoto, H.; Shan, B.; Walker, N.P.; Wang, Z.
Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem.
16
8922-8931
2008
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Saiah, E.
The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and therapeutic potential of 11beta-HSD1 inhibitors
Curr. Med. Chem.
15
642-649
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Swali, A.; Walker, E.A.; Lavery, G.G.; Tomlinson, J.W.; Stewart, P.M.
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
Diabetologia
51
2003-2011
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Balachandran, A.; Guan, H.; Sellan, M.; van Uum, S.; Yang, K.
Insulin and dexamethasone dynamically regulate adipocyte 11beta-hydroxysteroid dehydrogenase type 1
Endocrinology
149
4069-4079
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Mericq, V.; Medina, P.; Kakarieka, E.; Marquez, L.; Johnson, M.C.; Iniguez, G.
Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Eur. J. Endocrinol.
161
419-425
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, H.; Shen, Y.; Chen, J.; Jiang, Q.; Leng, Y.; Shen, J.
Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors
Eur. J. Med. Chem.
44
1167-1171
2009
Homo sapiens (P28845), Mus musculus
Manually annotated by BRENDA team
Gumy, C.; Thurnbichler, C.; Aubry, E.M.; Balazs, Z.; Pfisterer, P.; Baumgartner, L.; Stuppner, H.; Odermatt, A.; Rollinger, J.M.
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines
Fitoterapia
80
200-205
2009
Homo sapiens
Manually annotated by BRENDA team
Mericq, V.; Medina, P.; Bouwman, C.; Johnson, M.C.; Godoy, J.; Lopez, T.; Iniguez, G.
Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral adipose tissue of prepubertal children
Horm. Res.
71
89-93
2009
Homo sapiens
Manually annotated by BRENDA team
Cooper, M.S.
11beta-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis
J. Endocrinol. Invest.
31 (7 Suppl)
16-21
2008
Homo sapiens
Manually annotated by BRENDA team
Wan, Z.K.; Chenail, E.; Xiang, J.; Li, H.Q.; Ipek, M.; Bard, J.; Svenson, K.; Mansour, T.S.; Xu, X.; Tian, X.; Suri, V.; Hahm, S.; Xing, Y.; Johnson, C.E.; Li, X.; Qadri, A.; Panza, D.; Perreault, M.; Tobin, J.F.; Saiah, E.
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model
J. Med. Chem.
52
5449-5461
2009
Homo sapiens, Homo sapiens (P28845), Mus musculus
Manually annotated by BRENDA team
Anderson, S.; Carreiro, S.; Quenzer, T.; Gale, D.; Xiang, C.; Gukasyan, H.; Lafontaine, J.; Cheng, H.; Krauss, A.; Prasanna, G.
In vivo evaluation of 11beta-hydroxysteroid dehydrogenase activity in the rabbit eye
J. Ocul. Pharmacol. Ther.
25
215-222
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Chen, B.B.; Lin, H.; Hu, G.X.; Su, Y.; Zhou, H.Y.; Lian, Q.Q.; Cai, H.; Hardy, D.O.; Gu, D.Y.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
113
177-181
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Classen-Houben, D.; Schuster, D.; Da Cunha, T.; Odermatt, A.; Wolber, G.; Jordis, U.; Kueenburg, B.
Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid
J. Steroid Biochem. Mol. Biol.
113
248-252
2009
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
Expression and activities of 11betaHSD enzymes in the testes and reproductive tracts of sexually immature male pigs
J. Steroid Biochem. Mol. Biol.
115
98-106
2009
Sus scrofa
Manually annotated by BRENDA team
Wang, D.Y.; Lu, Q.; Walsh, S.L.; Payne, L.; Modha, S.S.; Scott, M.J.; Sweitzer, T.D.; Ames, R.S.; Krosky, D.J.; Li, H.
Development of a high-throughput cell-based assay for 11beta-hydroxysteroid dehydrogenase type 1 using BacMam technology
Mol. Biotechnol.
39
127-134
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chapman, K.E.; Coutinho, A.E.; Gray, M.; Gilmour, J.S.; Savill, J.S.; Seckl, J.R.
The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
Mol. Cell. Endocrinol.
301
123-131
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Blum, A.; Favia, A.D.; Maser, E.
11beta-Hydroxysteroid dehydrogenase type 1 inhibitors with oleanan and ursan scaffolds
Mol. Cell. Endocrinol.
301
132-136
2009
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Dzyakanchuk, A.A.; Balazs, Z.; Nashev, L.G.; Amrein, K.E.; Odermatt, A.
11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose
Mol. Cell. Endocrinol.
301
137-141
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Su, X.; Vicker, N.; Trusselle, M.; Halem, H.; Culler, M.D.; Potter, B.V.
Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
301
169-173
2009
Homo sapiens
Manually annotated by BRENDA team
Abbott, A.N.; Guidry, T.V.; Welsh, K.J.; Thomas, A.M.; Kling, M.A.; Hunter, R.L.; Actor, J.K.
11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6-dimycolate
Neuroimmunomodulation
16
147-154
2009
Mus musculus
Manually annotated by BRENDA team
Gong, R.; Morris, D.J.; Brem, A.S.
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells
Steroids
73
1187-1196
2008
Homo sapiens, Homo sapiens (P80365), Rattus norvegicus
Manually annotated by BRENDA team
Mondok, A.; Varga, I.; Glaz, E.; Szucs, N.; Toth, M.; Patocs, A.; Beko, G.; Racz, K.
11beta-hydroxysteroid dehydrogenase activity in acromegalic patients with normal or impaired carbohydrate metabolism
Steroids
74
725-729
2009
Homo sapiens
Manually annotated by BRENDA team
Skarydova, L.; Skarka, A.; Novotna, R.; Zivna, L.; Martin, H.J.; Wsol, V.; Maser, E.
Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
Toxicology
264
52-60
2009
Homo sapiens
Manually annotated by BRENDA team
Zhang, X.; Zhou, Y.; Shen, Y.; Du, L.L.; Chen, J.H.; Leng, Y.; Shen, J.H.
Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro
Acta Pharmacol. Sin.
30
1344-1350
2009
Homo sapiens, Homo sapiens (P28845), Mus musculus, Mus musculus (P50172)
Manually annotated by BRENDA team
Cho, Y.S.; Kim, C.H.; Cheon, H.G.
Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase 1 inhibitors
Anal. Biochem.
392
110-116
2009
Mus musculus
Manually annotated by BRENDA team
Sun, D.; Wang, Z.; Cardozo, M.; Choi, R.; Degraffenreid, M.; Di, Y.; He, X.; Jaen, J.C.; Labelle, M.; Liu, J.; Ma, J.; Miao, S.; Sudom, A.; Tang, L.; Tu, H.; Ursu, S.; Walker, N.; Yan, X.; Ye, Q.; Powers, J.P.
Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)
Bioorg. Med. Chem. Lett.
19
1522-1527
2009
Homo sapiens
Manually annotated by BRENDA team
Siu, M.; Johnson, T.O.; Wang, Y.; Nair, S.K.; Taylor, W.D.; Cripps, S.J.; Matthews, J.J.; Edwards, M.P.; Pauly, T.A.; Ermolieff, J.; Castro, A.; Hosea, N.A.; LaPaglia, A.; Fanjul, A.N.; Vogel, J.E.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
Bioorg. Med. Chem. Lett.
19
3493-3497
2009
Homo sapiens
Manually annotated by BRENDA team
Zhang, X.; Zhou, Z.; Yang, H.; Chen, J.; Feng, Y.; Du, L.; Leng, Y.; Shen, J.
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice
Bioorg. Med. Chem. Lett.
19
4455-4458
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kim, S.H.; Ramu, R.; Kwon, S.W.; Lee, S.H.; Kim, C.H.; Kang, S.K.; Rhee, S.D.; Bae, M.A.; Ahn, S.H.; Ha, D.C.; Cheon, H.G.; Kim, K.Y.; Ahn, J.H.
Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors
Bioorg. Med. Chem. Lett.
20
1065-1069
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Stanetty, C.; Czollner, L.; Koller, I.; Shah, P.; Gaware, R.; Cunha, T.D.; Odermatt, A.; Jordis, U.; Kosma, P.; Classen-Houben, D.
Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11beta-hydroxysteroid dehydrogenase 2 inhibitors
Bioorg. Med. Chem.
18
7522-7541
2010
Homo sapiens (P28845)
Manually annotated by BRENDA team
Feng, Y.; Huang, S.L.; Dou, W.; Zhang, S.; Chen, J.H.; Shen, Y.; Shen, J.H.; Leng, Y.
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice
Br. J. Pharmacol.
161
113-126
2010
Homo sapiens, Homo sapiens (P28845), Mus musculus
Manually annotated by BRENDA team
Xu, D.; Sheng, Y.; Zhou, Z.Y.; Liu, R.; Leng, Y.; Liu, J.K.
Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity
Chem. Pharm. Bull.
57
433-435
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Su, X.; Pradaux-Caggiano, F.; Thomas, M.P.; Szeto, M.W.; Halem, H.A.; Culler, M.D.; Vicker, N.; Potter, B.V.
Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors
ChemMedChem
5
1026-1044
2010
Homo sapiens, Homo sapiens (P28845)
Manually annotated by BRENDA team
Ge, R.; Huang, Y.; Liang, G.; Li, X.
11beta-hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: status and development
Curr. Med. Chem.
17
412-422
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Torres-Piedra, M.; Ortiz-Andrade, R.; Villalobos-Molina, R.; Singh, N.; Medina-Franco, J.L.; Webster, S.P.; Binnie, M.; Navarrete-Vazquez, G.; Estrada-Soto, S.
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition
Eur. J. Med. Chem.
45
2606-2612
2010
Homo sapiens (P28845)
Manually annotated by BRENDA team
Odermatt, A.
Diazepane-acetamide derivatives as selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
Expert Opin. Ther. Pat.
19
1477-1483
2009
Homo sapiens
Manually annotated by BRENDA team
Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity
J. Antibiot.
62
239-242
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Tagawa, N.; Yuda, R.; Kubota, S.; Wakabayashi, M.; Yamaguchi, Y.; Kiyonaga, D.; Mori, N.; Minamitani, E.; Masuzaki, H.; Kobayashi, Y.
17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes
J. Endocrinol.
202
131-139
2009
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Veniant, M.M.; Hale, C.; Hungate, R.W.; Gahm, K.; Emery, M.G.; Jona, J.; Joseph, S.; Adams, J.; Hague, A.; Moniz, G.; Zhang, J.; Bartberger, M.D.; Li, V.; Syed, R.; Jordan, S.; Komorowski, R.; Chen, M.M.; Cupples, R.; Kim, K.W.; St Jean, D.J.; Johansson, L.; Henriksson, M.A.; Williams, M.; Vallgarda, J.; Fots, F.o.t.s.c.
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
J. Med. Chem.
53
4481-4487
2010
Homo sapiens (P28845)
Manually annotated by BRENDA team
Kim, C.H.; Ramu, R.; Ahn, J.H.; Bae, M.A.; Cho, Y.S.
Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes
Mol. Cell. Biochem.
344
91-98
2010
Mus musculus
Manually annotated by BRENDA team
Zhang, L.; Shen, Y.; Wang, F.; Leng, Y.; Liu, J.K.
Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases
Phytochemistry
71
100-103
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Webster, S.P.; Binnie, M.; McConnell, K.M.; Sooy, K.; Ward, P.; Greaney, M.F.; Vinter, A.; Pallin, T.D.; Dyke, H.J.; Gill, M.I.; Warner, I.; Seckl, J.R.; Walker, B.R.
Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
Bioorg. Med. Chem. Lett.
20
3265-3271
2010
Homo sapiens, Homo sapiens (P28845), Mus musculus, Mus musculus (P50172)
Manually annotated by BRENDA team
Venier, O.; Pascal, C.; Braun, A.; Namane, C.; Mougenot, P.; Crespin, O.; Pacquet, F.; Mougenot, C.; Monseau, C.; Onofri, B.; Dadji-Faihun, R.; Leger, C.; Ben-Hassine, M.; Van-Pham, T.; Ragot, J.L.; Philippo, C.; Guessregen, S.; Engel, C.; Farjot, G.; Noah, L.; Maniani, K.; Nicolai, E.
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1
Bioorg. Med. Chem. Lett.
21
2244-2251
2011
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Wang, H.; Robl, J.A.; Hamann, L.G.; Simpkins, L.; Golla, R.; Li, Y.X.; Seethala, R.; Zvyaga, T.; Gordon, D.A.; Li, J.J.
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1)
Bioorg. Med. Chem. Lett.
21
4146-4149
2011
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Wu, S.C.; Yoon, D.; Chin, J.; van Kirk, K.; Seethala, R.; Golla, R.; He, B.; Harrity, T.; Kunselman, L.K.; Morgan, N.N.; Ponticiello, R.P.; Taylor, J.R.; Zebo, R.; Harper, T.W.; Li, W.; Wang, M.; Zhang, L.; Sleczka, B.G.; Nayeem, A.; Sheriff, S.; Camac, D.M.; Morin, P.E.; Everlof, J.G.; Li, Y.X.; Ferraro, C.A.; et al.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1)
Bioorg. Med. Chem. Lett.
21
6693-6698
2011
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Ye, X.Y.; Chen, S.Y.; Nayeem, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.; Sleczka, B.G.; Li, Y.X.; He, B.; Kirby, M.; Gordon, D.A.; Robl, J.A.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1)
Bioorg. Med. Chem. Lett.
21
6699-6704
2011
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Udagawa, S.; Sakami, S.; Takemura, T.; Sato, M.; Arai, T.; Nitta, A.; Aoki, T.; Kawai, K.; Iwamura, T.; Okazaki, S.; Takahashi, T.; Kaino, M.
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
23
1617-1621
2013
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Su, X.; Vicker, N.; Thomas, M.P.; Pradaux-Caggiano, F.; Halem, H.; Culler, M.D.; Potter, B.V.
Discovery of adamantyl heterocyclic ketones as potent 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
ChemMedChem
6
1439-1451
2011
Homo sapiens (P28845)
Manually annotated by BRENDA team
Xia, G.; Liu, L.; Liu, H.; Yu, J.; Xu, Z.; Chen, Q.; Ma, C.; Li, P.; Xiong, B.; Liu, X.; Shen, J.
Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors
ChemMedChem
8
577-581
2013
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Fernandino, J.I.; Hattori, R.S.; Kishii, A.; Struessmann, C.A.; Somoza, G.M.
The cortisol and androgen pathways cross talk in high temperature-induced masculinization: the 11beta-hydroxysteroid dehydrogenase as a key enzyme
Endocrinology
153
6003-6011
2012
Odontesthes bonariensis
Manually annotated by BRENDA team
Xu, Z.; Tice, C.M.; Zhao, W.; Cacatian, S.; Ye, Y.J.; Singh, S.B.; Lindblom, P.; McKeever, B.M.; Krosky, P.M.; Kruk, B.A.; Berbaum, J.; Harrison, R.K.; Johnson, J.A.; Bukhtiyarov, Y.; Panemangalore, R.; Scott, B.B.; Zhao, Y.; Bruno, J.G.; Togias, J.; Guo, J.; Guo, R.; Carroll, P.J.; McGeehan, G.M.; Zhuang, L. et al.
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
54
6050-6062
2011
Homo sapiens (P28845)
Manually annotated by BRENDA team
Rasheeda, M.K.; Kagawa, H.; Kirubagaran, R.; Dutta-Gupta, A.; Senthilkumaran, B.
Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus
J. Steroid Biochem. Mol. Biol.
120
1-10
2010
Clarias gariepinus
Manually annotated by BRENDA team
Kratschmar, D.V.; Vuorinen, A.; Da Cunha, T.; Wolber, G.; Classen-Houben, D.; Doblhoff, O.; Schuster, D.; Odermatt, A.
Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
125
129-142
2011
Homo sapiens (P28845)
Manually annotated by BRENDA team
Xia, G.; Liu, L.; Xue, M.; Liu, H.; Yu, J.; Li, P.; Chen, Q.; Xiong, B.; Liu, X.; Shen, J.
Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
358
46-52
2012
Homo sapiens (P28845), Mus musculus (P50172)
Manually annotated by BRENDA team
Favia, A.; Masetti, M.; Recanatini, M.; Cavalli, A.
Substrate binding process and mechanistic functioning of type 1 11beta-hydroxysteroid dehydrogenase from enhanced sampling methods
PLoS ONE
6
e25375
2011
Homo sapiens (P28845)
Manually annotated by BRENDA team
Hu, G.; Lin, H.; Lian, Q.; Zhou, S.; Guo, J.; Zhou, H.; Chu, Y.; Ge, R.
Curcumin as a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats
PLoS ONE
8
e49976
2013
Homo sapiens (P28845), Rattus norvegicus (P16232)
Manually annotated by BRENDA team
Latif, S.A.; Shen, M.; Ge, R.S.; Sottas, C.M.; Hardy, M.P.; Morris, D.J.
Role of 11beta-OH-C(19) and C(21) steroids in the coupling of 11beta-HSD1 and 17beta-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells
Steroids
76
682-689
2011
Rattus norvegicus (P16232)
Manually annotated by BRENDA team
Guo, J.; Deng, H.; Li, H.; Zhu, Q.; Zhao, B.; Chen, B.; Chu, Y.; Ge, R.S.
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11beta-hydroxysteroid dehydrogenase activities in vitro
Toxicol. Lett.
218
18-23
2013
Homo sapiens (P28845), Rattus norvegicus (P16232)
Manually annotated by BRENDA team