1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
11beta-HSD1 activity is increased in visceral adipose tissue in prepubertal children with normal weight
Manually annotated by BRENDA team
-
rectum, sigmoid colon
Manually annotated by BRENDA team
-
samples from hepatic, renal and peripheral veins
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
chorionic trophoblast cell
Manually annotated by BRENDA team
-
expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in occular ciliary body
Manually annotated by BRENDA team
-
expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in choroid plexus
Manually annotated by BRENDA team
-
presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
Manually annotated by BRENDA team
-
expression of mRNA for 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2 and for glucocorticoid receptor during the estrous cycle. Level of 11beta-hydroxysteroid dehydrogenase type 1 mRNA is higher at the regressed state than at the other stages, whereas level of 11beta-hydroxysteroid dehydrogenase type 2 mRNA is lower at the regressed stage than at the other stages
Manually annotated by BRENDA team
-
ovarian cyst
Manually annotated by BRENDA team
-
epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system
Manually annotated by BRENDA team
-
of secretory choroid plexus, predominant expression of isoform 11beta-HSD1
Manually annotated by BRENDA team
-
of the vas defernes
Manually annotated by BRENDA team
-
11beta-HSD1 is widely expressed in the eye, particularly ciliary epithelium
Manually annotated by BRENDA team
-
isoform 11betaHSD1
Manually annotated by BRENDA team
-
prominent expression in testis, anterior kidney, liver and gills
Manually annotated by BRENDA team
-
high expression; high level of expression and activity
Manually annotated by BRENDA team
-
peripheral lymph nodes and mesenteric lymph nodes
Manually annotated by BRENDA team
-
isoform 11betaHSD2
Manually annotated by BRENDA team
-
lung epithelial cell line, isozymes HSD1 and HSD2
Manually annotated by BRENDA team
-
aldosterone-insensitive, NADP+ specificity
Manually annotated by BRENDA team
-
isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes
Manually annotated by BRENDA team
-
renal cortical collecting duct cell line
Manually annotated by BRENDA team
-
of the vas deferens and penile blood vessels
Manually annotated by BRENDA team
-
significant expression of isoform 11beta-HSD2 protein is found at single cell level in thymus parenchyma, at perivascular sites of capillaries and small vessels penetrating the thymus lobuli and within Hassall's bodies
Manually annotated by BRENDA team
-
chorionic trophoblast cell
Manually annotated by BRENDA team
-
expression of isozyme 11beta-HSD1 in intrauterine tissue, overview
Manually annotated by BRENDA team
-
splanchnic activity
Manually annotated by BRENDA team
-
amnion-derived cell line
Manually annotated by BRENDA team
additional information