1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, Hsd11B2, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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11beta-HSD1 activity is increased in visceral adipose tissue in prepubertal children with normal weight
Manually annotated by BRENDA team
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rectum, sigmoid colon
Manually annotated by BRENDA team
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samples from hepatic, renal and peripheral veins
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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chorionic trophoblast cell
Manually annotated by BRENDA team
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expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in occular ciliary body
Manually annotated by BRENDA team
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expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in choroid plexus
Manually annotated by BRENDA team
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
Manually annotated by BRENDA team
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expression of mRNA for 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2 and for glucocorticoid receptor during the estrous cycle. Level of 11beta-hydroxysteroid dehydrogenase type 1 mRNA is higher at the regressed state than at the other stages, whereas level of 11beta-hydroxysteroid dehydrogenase type 2 mRNA is lower at the regressed stage than at the other stages
Manually annotated by BRENDA team
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ovarian cyst
Manually annotated by BRENDA team
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epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system
Manually annotated by BRENDA team
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of secretory choroid plexus, predominant expression of isoform 11beta-HSD1
Manually annotated by BRENDA team
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of the vas defernes
Manually annotated by BRENDA team
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11beta-HSD1 is widely expressed in the eye, particularly ciliary epithelium
Manually annotated by BRENDA team
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prominent expression in testis, anterior kidney, liver and gills
Manually annotated by BRENDA team
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high expression; high level of expression and activity
Manually annotated by BRENDA team
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peripheral lymph nodes and mesenteric lymph nodes
Manually annotated by BRENDA team
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lung epithelial cell line, isozymes HSD1 and HSD2
Manually annotated by BRENDA team
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aldosterone-insensitive, NADP+ specificity
Manually annotated by BRENDA team
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isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes
Manually annotated by BRENDA team
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renal cortical collecting duct cell line
Manually annotated by BRENDA team
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of the vas deferens and penile blood vessels
Manually annotated by BRENDA team
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chorionic trophoblast cell
Manually annotated by BRENDA team
isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
Manually annotated by BRENDA team
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expression of isozyme 11beta-HSD1 in intrauterine tissue, overview
Manually annotated by BRENDA team
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splanchnic activity
Manually annotated by BRENDA team
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amnion-derived cell line
Manually annotated by BRENDA team
additional information