1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
+
NADPH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, Hsd11B2, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

Cloned

Cloned on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Baculovirus-produced recombinant protein
-
cloning from clone 5193867, ATCC clone 7277078, expression of isozyme 11beta-HSD1 catalytic domain mutant C272S, comprising residues 24-292 proceeded by a 17-amino acid-affinity tag, in Escherichia coli strain DH10b-Tir
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cloning of cDNA
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expressed in CHO cells
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expressed in Escherichia coli
-
expressed in HEK-293 cell
expressed in HEK-293 cells
expressed in HEK-293 cells, co-expression of hexose-6-phosphate dehydrogenase is not required for the enzyme to function effectively as an oxo-reductase
-
expressed in in Hi5 cells via a baculovirus protein expression system and in Escherichia coli Rosetta1(DE3) cells
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expressed in rat H4IIE hepatoma cells
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expression in CHO cells
expression in COS-7 cell
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expression in Escherichia coli and Pichia pastoris
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expression in Escherichia coli, catalytic domain
-
expression in HEK-293 cell
expression in HEK-293 cell of 11beta-hydroxysteroid dehydrogenase alone or together with hexose-6-phosphate dehydrogenase
-
expression in HEK-293 cells
expression in HEK293 cells
-
expression in Pichia pastoris
expression in Saccharomyces cerevisiae
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expression in TK-143 B cells by vaccinia virus infection
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expression inEscherichia coli of N-terminally deleted gene, amino acids 24-292, with an N-terminal His-tag
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expression of 11beta-HSD1 in Pichia pastoris, COS cells and Escherichia coli
expression of His-tagged 11beta-HSD1 in Pichia pastoris; expression of N-terminally His6-tagged isozyme 11beta-HSD1 in Pichia pastoris strain GS115 membranes
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expression of His6-tagged enzyme in Escherichia coli
expression of His6-tagged isozyme 11beta-HSD1 in Escherichia coli strain BL21(DE3)
expression of isozyme 11beta-HSD1 in HEK-293 cells
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expression Pichia pastoris
-
isoform 11beta-HSD1, expression in HEK-293 cell
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isozyme 11beta-HSD1 is expressed in Pichia pastoris
-
overexpressed in HEK-293 cell
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stable expression of isozymes 11beta-HSD1 and 11beta-HSD2 in CHO cells
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the 11beta-HSD1 enzyme is expressed in Escherichia coli
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