EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell line |
- |
742626, 743379, 743882 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell line |
increased expression of aspartate beta-hydroxylase in hepatocellular carcinoma tissues is associated with tumor invasiveness and a worse prognosis. Aspartate beta-hydroxylase overexpression in hepatocellular carcinoma tissues is correlated with decreased copy numbers of displacement loop (D-loop) and NADH dehydrogenase subunit 1 and enhanced D-loop mutation, suggesting the disrupted mitochondrial DNA (mtDNA) stability. The reduced mtDNA copy numbers are associated with aggressive clinicopathological features of hepatocellular carcinoma. The loss of mtDNA integrity induced by enforced expression of Aspartate beta-hydroxylase is accompanied with mitochondrial dysfunction, which is characterized by the aberrant mitochondrial membrane potential, decreased ATP generation and enhanced reactive oxygen species. The enzyme interacts with histone H2A member X. Overexpression of aspartate beta-hydroxylase diminishes the interaction between histone H2A member X and mitochondrial transcription factor A (mtTFA), an important DNA-binding protein for mtDNA replication, which then reduced the binding of mtTFA to D-loop region. Overexpression of aspartate beta-hydroxylase disrupts the mtDNA integrity through H2AX-mtTFA signal, thereby affecting mitochondrial functions in hepatocellular carcinoma |
743376 |
1.14.11.18 | phytanoyl-CoA dioxygenase |
hepatoma cell line |
- |
285272 |
1.14.15.3 | alkane 1-monooxygenase |
hepatoma cell line |
- |
673653 |
1.4.3.3 | D-amino-acid oxidase |
hepatoma cell line |
101L cell |
697313 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
hepatoma cell line |
full-length sequence is amplified from a hepatoma cell line cDNA library |
676969 |
2.1.1.5 | betaine-homocysteine S-methyltransferase |
hepatoma cell line |
hyperosmolarity (405 mosmol/l) suppresses Bhmt mRNA expression whereas hypoosmotic (205 mosmol/l) conditions induce Bhmt mRNA expression. Like hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression. Osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases |
671242 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell line |
7721 cell |
638226 |
2.5.1.26 | alkylglycerone-phosphate synthase |
hepatoma cell line |
the enzyme is upregulated in multiple types of cancer cells and primary tumors |
737578 |
2.7.1.1 | hexokinase |
hepatoma cell line |
AS-30D, highly glycolytic tumor cells |
640210 |
2.7.1.30 | glycerol kinase |
hepatoma cell line |
HaIIE (ATCC) |
705749 |
2.7.1.32 | choline kinase |
hepatoma cell line |
Hepa-1 |
685337 |
2.7.1.36 | mevalonate kinase |
hepatoma cell line |
cell line PLC/PRF/5 |
641446 |
2.7.10.2 | non-specific protein-tyrosine kinase |
hepatoma cell line |
PLC cell |
691651 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hepatoma cell line |
The human liver cancer cell line HepG3B was obtained from the cell bank of the Institute of Biochemistry and Cell Biology |
761575 |
2.7.4.6 | nucleoside-diphosphate kinase |
hepatoma cell line |
Novikoff |
642661 |
2.8.3.5 | 3-oxoacid CoA-transferase |
hepatoma cell line |
H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues |
695186 |
3.1.4.1 | phosphodiesterase I |
hepatoma cell line |
PLC/ PRF/5 human hepatoma |
208356 |
3.2.1.207 | mannosyl-oligosaccharide alpha-1,3-glucosidase |
hepatoma cell line |
- |
136899 |
3.4.21.68 | t-Plasminogen activator |
hepatoma cell line |
transformed |
29575 |
3.4.24.35 | gelatinase B |
hepatoma cell line |
- |
697085 |
3.5.1.114 | N-acyl-aromatic-L-amino acid amidohydrolase |
hepatoma cell line |
AA3 expression in the hepatocellular carcinoma cell lines is 5 to 20 times greater than in normal primary hepatocytes |
754228 |
4.1.1.22 | histidine decarboxylase |
hepatoma cell line |
- |
693822 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatoma cell line |
H4IIEC3 cells, mRNA is 5-10fold elevated in cells cultured at high density compared to low density, KRC-7 cells, an H4IIEC3 subclone, are much more sensitive to growth arrest than its parental cell line |
649586 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
hepatoma cell line |
Reuber H365 hepatoma cells |
4364 |
4.2.1.1 | carbonic anhydrase |
hepatoma cell line |
- |
700140 |
6.3.5.2 | GMP synthase (glutamine-hydrolysing) |
hepatoma cell line |
- |
1384 |