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Literature summary for 2.7.11.2 extracted from

  • Deng, X.; Wang, Q.; Cheng, M.; Chen, Y.; Yan, X.; Guo, R.; Sun, L.; Li, Y.; Liu, Y.
    Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer (2020), J. Cancer, 11, 962-973 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Dichloroacetate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell line The human liver cancer cell line HepG3B was obtained from the cell bank of the Institute of Biochemistry and Cell Biology Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDKI
-
 Homo sapiens
pyruvate dehydrogenase kinase I
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of isoform PDK1 decreases cell proliferation and induces cell cycle arrest, cell apoptosis and oxidative damage. Isoform PDK1 inhibition in HepG2 and HepG3B cancer cells affects the level of mitochondrial quality control. Analysis of mitochondrial function reveals significantly increased mitochondrial reactive oxygen species and decreased membrane potential. Therefore, glucose metabolism reprogramming by PDK1 inhibition can induce mitochondrial quality control disorders to aggravate mitochondrial stress damage Homo sapiens