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Information on EC - N-acyl-aromatic-L-amino acid amidohydrolase

for references in articles please use BRENDA:EC3.5.1.114
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IUBMB Comments
This enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It preferentially deacetylates Nalpha-acetylated aromatic amino acids and mercapturic acids (S-conjugates of N-acetyl-L-cysteine) that are usually not deacetylated by EC, N-acyl-aliphatic-L-amino acid amidohydrolase. The enzyme is significantly activated by Co2+ and Ni2+ . Some bacterial aminoacylases demonstrate substrate specificity for both EC and EC cf. EC, N-acyl-aliphatic-L-amino acid amidohydrolase and EC, aspartoacylase.
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The enzyme appears in viruses and cellular organisms
AA3, AAIII, Acy3, aminoacylase 3, aminoacylase III, more
an N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate
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an N-acyl-aromatic-L-amino acid + H2O = an aromatic-L-amino acid + a carboxylate
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