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Literature summary for 3.5.1.114 extracted from

  • Hsieh, J.M.; Tsirulnikov, K.; Sawaya, M.R.; Magilnick, N.; Abuladze, N.; Kurtz, I.; Abramson, J.; Pushkin, A.
    Structures of aminoacylase 3 in complex with acetylated substrates (2010), Proc. Natl. Acad. Sci. USA, 107, 17962-17967.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.114

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of recombinant mouse AA3 (mAA3) in the presence of its acetate byproduct and two substrates: Nalpha-acetyl-L-tyrosine and N-acetyl-S-1,2-dichlorovinyl-L-cysteine Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information trichloroethylene is one of the most widespread environmental contaminants, which is metabolized to N-acetyl-S-1,2-dichlorovinyl-L-cysteine (NA-DCVC) before being excreted in the urine. Alternatively, NA-DCVC can be deacetylated by aminoacylase 3, an enzyme that is highly expressed in the kidney, liver, and brain. NA-DCVC deacetylation initiates the transformation into toxic products that ultimately causes acute renal failure. Aminoacylase 3 inhibition is therefore a target of interest to prevent TCE induced nephrotoxicity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q91XE4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
AA3
-
 Mus musculus