EC Number   |
General Information |
Reference |
|---|
   3.5.1.114 | malfunction |
aminoacylase 3 inhibition completely protects rat brain cortex neurons expressing the enzyme from the toxicity of 4-hydroxy-2-nonenal-mercapturate. 4-hydroxy-2-nonenal-cysteine is also neurotoxic and its toxicity is mostly prevented by a beta-lyase inhibitor, aminooxyacetate |
-, 723787 |
| 3.5.1.114 | physiological function |
aminoacylase III contributes to the nephrotoxicity to cysteine S-conjugates |
710809 |
| 3.5.1.114 | physiological function |
the enzyme cleaves the conjugates 4-hydroxy-2-nonenal mercapturate and acrolein mercapturate formed by reaction with glutathione for detoxification in the GSH-conjugation pathway, overview. Aminoacylase 3 is involved in the neurotoxicity of the compounds 4-hydroxy-2-nonenal and acrolein |
-, 723787 |
| 3.5.1.114 | physiological function |
the enzyme mediates deacetylation of N-acetyl aromatic amino acids and mercapturic acids. Deacetylation of mercapturic acids of exo- and endobiotics are likely involved in their toxicity |
733862 |
| 3.5.1.114 | physiological function |
the enzyme mediates deacetylation of the mercapturic acids derived from the metabolism of trichloroethylene in the proximal tubule cells, and this process is involved in their toxicity |
679474 |
