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Synonyms
choline kinase, choline kinase alpha, chokalpha, choline kinase beta, choline/ethanolamine kinase, chk-alpha, chokalpha1, ck-alpha, schok, choline kinase-alpha,
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ATP + choline = ADP + phosphocholine
ATP + choline = ADP + phosphocholine
random bi-bi mechanism
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are 2 distinct enzymes
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ATP + choline = ADP + phosphocholine
forward reaction: ordered mechanism with MgATP2- binding first, followed by choline
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ATP + choline = ADP + phosphocholine
ethanolamine kinase II and choline kinase do not use a common active site
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ATP + choline = ADP + phosphocholine
forward reaction follows a sequentially ordered mechanism
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase may not have a common active site in a single enzyme protein
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase activities are mediated by 2 distinct active sites, possibly on a single protein
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ATP + choline = ADP + phosphocholine
sequential bi bi reaction
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase are identical
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ATP + choline = ADP + phosphocholine
ethanolamine and its methyl and ethyl derivatives can also act as acceptors
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase activities reside on the same protein and occur at the same active site
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ATP + choline = ADP + phosphocholine
choline kinase and ethanolamine kinase activities reside on the same protein and occur at the same active site
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ATP + choline = ADP + phosphocholine
reaction mechanism of choline kinase alpha, overview
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2-(dimethylamino)-ethanol + ATP
ADP + 2-(dimethylamino)-ethyl phosphate
2-aminoethanol + ATP
ADP + 2-aminoethyl phosphate
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?
2-methylaminoethanol + ATP
ADP + 2-methylaminoethyl phosphate
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-
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?
ATP + choline
ADP + O-phosphocholine
ATP + choline
ADP + phosphocholine
ATP + dimethylethanolamine
ADP + phosphodimethylethanolamine
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?
ATP + ethanolamine
ADP + ethanolamine phosphate
ATP + ethanolamine
ADP + O-phosphoethanolamine
ATP + ethanolamine
ADP + phosphoethanolamine
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?
beta-methylcholine + ATP
ADP + beta-methylcholine phosphate
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?
choline + ATP
O-phosphocholine + ADP
choline + ATP
phosphocholine + ADP
choline + ATP
phosphorylcholine + ADP
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?
CTP + choline
CDP + choline phosphate
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12% of the activity with ATP
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?
diethanolamine + ATP
ADP + O-phospho-diethanolamine
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?
ethanolamine + ATP
ADP + ethanolamine phosphate
ethanolamine + ATP
O-phosphoethanolamine + ADP
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first step in the biosynthesis of the glycerophospholipid glycerophosphoethanolamine
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?
ethanolamine + ATP
phosphoethanolamine + ADP
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?
GTP + choline
GDP + choline phosphate
N,N,N-triethylethanolamine + ATP
ADP + N,N,N-triethylethanolamine phosphate
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weak
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?
N,N-diethyl-N-methylethanolamine + ATP
ADP + N,N-diethyl-N-methylethanolamine phosphate
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weak
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?
N,N-diethylethanolamine + ATP
ADP + N,N-diethylethanolamine phosphate
N,N-diethylethanolamine + ATP
ADP + O-phospho-N-diethylethanolamine
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-
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?
N,N-diisopropylethanolamine + ATP
ADP + N,N-diisopropylethanolamine phosphate
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?
N,N-dimethyl-N-propylethanolamine + ATP
ADP + N,N-dimethyl-N-propylethanolamine phosphate
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?
N,N-dimethylaminopropanol + ATP
ADP + N,N-dimethylaminopropyl phosphate
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-
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?
N,N-dimethylethanolamine + ATP
ADP + N,N-dimethylethanolamine phosphate
N,N-dimethylethanolamine + ATP
ADP + O-phospho-N,N-dimethylethanolamine
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-
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?
N,N-dimethylethylcholine + ATP
ADP + N,N-dimethylethylcholine phosphate
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-
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?
N,N-dimethylisopropylcholine + ATP
ADP + N,N-dimethylisopropylcholine phosphate
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-
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?
N,N-dimethylpropylcholine + ATP
ADP + N,N-dimethylpropylcholine phosphate
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-
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?
N-ethylethanolamine + ATP
ADP + O-phospho-N-ethylethanolamine
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-
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?
N-methylethanolamine + ATP
ADP + N-methylethanolamine phosphate
N-methylethanolamine + ATP
ADP + O-phospho-N-methylethanolamine
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-
-
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?
N-monoethylethanolamine + ATP
ADP + N-monoethylethanolamine phosphate
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-
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?
N-monomethylethanolamine + ATP
ADP + N-monomethylethanolamine phosphate
UTP + choline
UDP + choline phosphate
additional information
?
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2-(dimethylamino)-ethanol + ATP
ADP + 2-(dimethylamino)-ethyl phosphate
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?
2-(dimethylamino)-ethanol + ATP
ADP + 2-(dimethylamino)-ethyl phosphate
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, increased activity under salt stress and cold conditions
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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initial step of the CDP-choline pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway
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?
ATP + choline
ADP + O-phosphocholine
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choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway
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?
ATP + choline
ADP + O-phosphocholine
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initial step of the CDP-choline pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, possible role in carcinogenesis
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?
ATP + choline
ADP + O-phosphocholine
initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, the product O-phosphocholine serves as second messenger and is essential for cell growth, enzyme plays a role in tumor generation
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
the catalytic efficiency (Vmax/Km) using choline as substrate is 2000fold greater than the efficiency using ethanolamine as substrate
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?
ATP + choline
ADP + O-phosphocholine
the catalytic efficiency (Vmax/Km) using choline as substrate is 2000fold greater than the efficiency using ethanolamine as substrate
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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initial step of the CDP-choline pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, involved in cell stress response
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?
ATP + choline
ADP + O-phosphocholine
initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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enzyme of the CDP-choline pathway of lecithin biosynthesis
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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641347, 641348, 641349, 641352, 641359, 641360, 641366, 641368, 641370, 641371, 641372, 663274, 673201 -
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?
ATP + choline
ADP + O-phosphocholine
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both isoforms
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?
ATP + choline
ADP + O-phosphocholine
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initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway
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?
ATP + choline
ADP + O-phosphocholine
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choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway
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?
ATP + choline
ADP + O-phosphocholine
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enzyme of the CDP-choline pathway of lecithin biosynthesis
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?
ATP + choline
ADP + O-phosphocholine
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initial step of the CDP-choline pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction and cell stress regulation
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?
ATP + choline
ADP + O-phosphocholine
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r
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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?
ATP + choline
ADP + O-phosphocholine
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r
ATP + choline
ADP + O-phosphocholine
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initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway
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-
?
ATP + choline
ADP + O-phosphocholine
-
initial step of the CDP-choline pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction
-
-
?
ATP + choline
ADP + O-phosphocholine
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-
-
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?
ATP + choline
ADP + O-phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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?
ATP + choline
ADP + phosphocholine
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-
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?
ATP + choline
ADP + phosphocholine
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-
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?
2.7.1.32 choline kinase
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