Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + choline | Homo sapiens | - |
ADP + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35790 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MG-63 cell | - |
Homo sapiens | - |
osteoblast | - |
Homo sapiens | - |
osteosarcoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + choline | - |
Homo sapiens | ADP + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
choline kinase alpha | - |
Homo sapiens |
CK-alpha | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | choline kinase activity and expression in MG-63 cells are significantly higher than those in primary human osteoblasts | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the silencing of choline kinase alpha reduces cell proliferation. Moreover, pharmacological inhibition of choline kinase activity impairs the mineralization capacity of MG-63 cells | Homo sapiens |
physiological function | choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells | Homo sapiens |