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Literature summary for 2.7.1.32 extracted from

  • Alberge, B.; Gannoun-Zaki, L.; Bascunana, C.; Tran van Ba, C.; Vial, H.; Cerdan, R.
    Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases (2010), Biochem. J., 425, 149-158.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
His-tag, expressed in Escherichia coli BL21(DE3)-pRIL Plasmodium falciparum 3D7

Inhibitors

Inhibitors Comment Organism Structure
2-amino-1-butanol
-
Plasmodium falciparum 3D7
hemicholinium-3
-
Plasmodium falciparum 3D7
SAR97276
-
Plasmodium falciparum 3D7

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
ethanolamine above 500 mM Plasmodium falciparum 3D7
0.1353
-
choline recombinant protein Plasmodium falciparum 3D7

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
1 * 52000, gel filtration Plasmodium falciparum 3D7

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum 3D7 Q8IM71
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Plasmodium falciparum 3D7

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
62.2 micromol/min/mg for ethanolamine Plasmodium falciparum 3D7
10.8
-
recombinant protein Plasmodium falciparum 3D7

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
choline + ATP
-
Plasmodium falciparum 3D7 O-phosphocholine + ADP
-
?

Subunits

Subunits Comment Organism
monomer 1 * 52000, gel filtration Plasmodium falciparum 3D7

Synonyms

Synonyms Comment Organism
choline kinase
-
Plasmodium falciparum 3D7

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.9
-
SAR97276 calculated from Dixon analysis Plasmodium falciparum 3D7
1.03
-
SAR97276 calculated from Lineweaver-Burk analysis Plasmodium falciparum 3D7

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.22
-
endogenous enzyme Plasmodium falciparum 3D7 hemicholinium-3
0.52
-
endogenous enzyme Plasmodium falciparum 3D7 SAR97276
0.58
-
recombinant enzyme Plasmodium falciparum 3D7 hemicholinium-3
1.12
-
recombinant enzyme Plasmodium falciparum 3D7 SAR97276
3.2
-
endogenous enzyme Plasmodium falciparum 3D7 2-amino-1-butanol