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Literature summary for 2.7.1.32 extracted from

  • Uchida, T.; Yamashita, S.
    Purification and properties of choline kinase from rat brain (1990), Biochim. Biophys. Acta, 1043, 281-288.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Acetylcholine stimulates Rattus norvegicus
putrescine slight stimulation Rattus norvegicus
spermidine stimulates Rattus norvegicus
spermine stimulates Rattus norvegicus

General Stability

General Stability Organism
very stable, even at a low protein concentration, 0.001 mg/ml Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
0.022
-
N,N-dimethylethanolamine 30°C, pH 8.0 Rattus norvegicus
0.025
-
N,N-diethylethanolamine 30°C, pH 8.0 Rattus norvegicus
0.118
-
N-Monomethylethanolamine 30°C, pH 8.0 Rattus norvegicus
0.208
-
N,N-Dimethylaminopropanol 30°C, pH 8.0 Rattus norvegicus
0.4
-
N,N-Diisopropylethanolamine 30°C, pH 8.0 Rattus norvegicus
0.444
-
beta-Methylcholine 30°C, pH 8.0 Rattus norvegicus
0.787
-
ethanolamine 30°C, pH 8.0 Rattus norvegicus
1
-
ATP 30°C, pH 8.0 Rattus norvegicus
1.2
-
ethanolamine 30°C, pH 8.0 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Carpronium chloride stimulates Rattus norvegicus
Chlorocholine chloride stimulates Rattus norvegicus
K+ stimulates Rattus norvegicus
Li+ stimulates Rattus norvegicus
Mg2+ MgATP2- is the true substrate Rattus norvegicus
Mg2+ stimulates most efficiently of divalent cations Rattus norvegicus
Mg2+ maximal activity at equimolar concentration of ATP and Mg2+ Rattus norvegicus
Mn2+ one-sixth as effective as Mg2+ Rattus norvegicus
additional information Co2+, Cd2+: almost completely ineffective, Ca2+, Ni2+, Zn2+: totally ineffective Rattus norvegicus
Na+ stimulates Rattus norvegicus
NH4+ stimulates Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
2 * 44000, brain enzyme, SDS-PAGE Rattus norvegicus
87600
-
sucrose density gradient centrifugation, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
40.4
-
30°C, pH 8.0 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + choline
-
Rattus norvegicus ADP + O-phosphocholine
-
?
beta-methylcholine + ATP
-
Rattus norvegicus ADP + beta-methylcholine phosphate
-
?
ethanolamine + ATP
-
Rattus norvegicus ADP + ethanolamine phosphate
-
?
N,N-diethylethanolamine + ATP
-
Rattus norvegicus ADP + N,N-diethylethanolamine phosphate
-
?
N,N-diisopropylethanolamine + ATP
-
Rattus norvegicus ADP + N,N-diisopropylethanolamine phosphate
-
?
N,N-dimethylaminopropanol + ATP
-
Rattus norvegicus ADP + N,N-dimethylaminopropyl phosphate
-
?
N,N-dimethylethanolamine + ATP
-
Rattus norvegicus ADP + N,N-dimethylethanolamine phosphate
-
?
N-methylethanolamine + ATP
-
Rattus norvegicus ADP + N-methylethanolamine phosphate
-
?
N-monomethylethanolamine + ATP
-
Rattus norvegicus ADP + N-monomethylethanolamine phosphate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 44000, brain enzyme, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
10.5
-
increase of activity up to Rattus norvegicus