Reference on EC 1.3.1.24 - biliverdin reductase and Organism(s) Homo sapiens and UniProt Accession P30043
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Singleton, J.W.; Laster, L.
Biliverdin reductase of guinea pig liver
J. Biol. Chem.
240
4780-4789
1965
Cavia porcellus, Homo sapiens
Salim, M.; Brown-Kipphut, B.A.; Maines, M.D.
Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation
J. Biol. Chem.
276
10929-10934
2001
Homo sapiens
Cunningham, O.; Dunne, A.; Sabido, P.; Lightner, D.; Mantle, T.J.
Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites
J. Biol. Chem.
275
19009-19017
2000
Homo sapiens
Ahmad, Z.; Salim, M.; Maines, M.D.
Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress
J. Biol. Chem.
277
9226-9232
2002
Homo sapiens
Maines, M.D.; Trakshel, G.M.
Purification and characterization of human biliverdin reductase
Arch. Biochem. Biophys.
300
320-326
1993
Homo sapiens, Rattus norvegicus
Maines, M.D.; Mayer, R.D.; Erturk, E.; Huang, T.J.; Disantagnese, A.
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma - pH and cofactor-specific increase in activity
J. Urol.
162
1467-1472
1999
Homo sapiens
Colpaert, E.E.; Timmermans, J.P.; Lefebvre, R.A.
Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 in human and pig gastric fundus
Free Radic. Biol. Med.
32
630-637
2002
Homo sapiens, Sus scrofa
Kravets, A.; Hu, Z.; Miralem, T.; Torno, M.D.; Maines, M.D.
Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
J. Biol. Chem.
279
19916-19923
2004
Homo sapiens
Miralem, T.; Hu, Z.; Torno, M.D.; Lelli, K.M.; Maines, M.D.
siRNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells
J. Biol. Chem.
280
17084-17092
2005
Homo sapiens
Baranano, D.E.; Rao, M.; Ferris, C.D.; Snyder, S.H.
Biliverdin reductase: a major physiologic cytoprotectant
Proc. Natl. Acad. Sci. USA
99
16093-16098
2002
Homo sapiens
Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.
Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
Proc. Natl. Acad. Sci. USA
102
7109-7114
2005
Homo sapiens
Maines, M.D.; Miralem, T.; Lerner-Marmarosh, N.; Shen, J.; Gibbs, P.E.
Human biliverdin reductase - a previously unknown activator of protein kinase C beta II
J. Biol. Chem.
282
8110-8122
2007
Homo sapiens
Maines, M.D.
New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
Physiology
20
382-389
2005
Arabidopsis sp., Canis lupus familiaris, Cavia porcellus, Gallus gallus, Cyanidium caldarium, Homo sapiens, Mus musculus, Pan troglodytes, Rattus norvegicus, Sus scrofa, Takifugu rubripes, Xenopus sp.
Maines, M.D.
Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways
Antioxid. Redox Signal.
9
2187-2195
2007
Homo sapiens
Tudor, C.; Lerner-Marmarosh, N.; Engelborghs, Y.; Gibbs, P.E.; Maines, M.D.
Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin
Biochem. J.
413
405-416
2008
Homo sapiens
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
FASEB J.
21
3949-3962
2007
Homo sapiens
Gibbs, P.E.; Maines, M.D.
Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase
Int. J. Cancer
121
2567-2574
2007
Homo sapiens
Wu, B.; Liu, X.; Shen, J.
Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target
Med. Hypotheses
71
73-76
2008
Homo sapiens
Florczyk, U.M.; Jozkowicz, A.; Dulak, J.
Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance
Pharmacol. Rep.
60
38-48
2008
Rattus norvegicus, Rattus norvegicus (P46844), Homo sapiens (P30043), Homo sapiens (P53004)
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
Proc. Natl. Acad. Sci. USA
105
6870-6875
2008
Homo sapiens
Wegiel, B.; Baty, C.J.; Gallo, D.; Csizmadia, E.; Scott, J.R.; Akhavan, A.; Chin, B.Y.; Kaczmarek, E.; Alam, J.; Bach, F.H.; Zuckerbraun, B.S.; Otterbein, L.E.
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
J. Biol. Chem.
284
21369-21378
2009
Homo sapiens, Mus musculus
Maghzal, G.J.; Leck, M.C.; Collinson, E.; Li, C.; Stocker, R.
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase
J. Biol. Chem.
284
29251-29259
2009
Homo sapiens
Gafvels, M.; Holmstroem, P.; Somell, A.; Sjoevall, F.; Svensson, J.O.; Stahle, L.; Broome, U.; Stal, P.
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)
Liver Int.
29
1116-1124
2009
Homo sapiens
Perez, M.J.; Castano, B.; Jimenez, S.; Serrano, M.A.; Gonzalez-Buitrago, J.M.; Marin, J.J.
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy
Toxicol. Appl. Pharmacol.
232
327-336
2008
Rattus norvegicus, Homo sapiens (P53004), Homo sapiens
Kapitulnik, J.; Maines, M.D.
Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
Trends Pharmacol. Sci.
30
129-137
2009
Homo sapiens
Florczyk, U.; Golda, S.; Zieba, A.; Cisowski, J.; Jozkowicz, A.; Dulak, J.
Overexpression of biliverdin reductase enhances resistance to chemotherapeutics
Cancer Lett.
300
40-47
2010
Homo sapiens (P53004)
Mancuso, C.; Barone, E.
The heme oxygenase/biliverdin reductase pathway in drug research and development
Curr. Drug Metab.
10
579-594
2009
Homo sapiens, Rattus norvegicus
Maines, M.D.
Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings
Curr. Drug Targets
11
1586-1594
2010
Homo sapiens
Ding, B.; Gibbs, P.E.; Brookes, P.S.; Maines, M.D.
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction
FASEB J.
25
301-313
2010
Homo sapiens, Rattus norvegicus
Jansen, T.; Hortmann, M.; Oelze, M.; Opitz, B.; Steven, S.; Schell, R.; Knorr, M.; Karbach, S.; Schuhmacher, S.; Wenzel, P.; Muenzel, T.; Daiber, A.
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin
J. Mol. Cell. Cardiol.
49
186-195
2010
Homo sapiens
Goven, D.; Boutten, A.; Lecon-Malas, V.; Marchal-Somme, J.; Soler, P.; Boczkowski, J.; Bonay, M.
Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha
PLoS ONE
5
e10886
2010
Homo sapiens
Barone, E.; Di Domenico, F.; Cenini, G.; Sultana, R.; Cini, C.; Preziosi, P.; Perluigi, M.; Mancuso, C.; Butterfield, D.A.
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment
Biochim. Biophys. Acta
1812
480-487
2011
Homo sapiens
Reed, J.R.; Huber, W.J.; Backes, W.L.
Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase
Drug Metab. Dispos.
38
2060-2066
2010
Homo sapiens
Kim, S.Y.; Kang, H.T.; Choi, H.R.; Park, S.C.
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
Exp. Mol. Med.
43
15-23
2011
Homo sapiens
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB
FASEB J.
24
3239-3254
2010
Homo sapiens
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Tudor, C.; Hagen, F.K.; Maines, M.D.
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C
J. Biol. Chem.
287
24698-24712
2012
Homo sapiens
Fu, G.; Liu, H.; Doerksen, R.J.
Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXalpha reductase
J. Phys. Chem. B
116
9580-9594
2012
Homo sapiens
Franklin, E.; Mantle, T.; Dunne, A.
Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway
Biochim. Biophys. Acta
1834
2573-2578
2013
Homo sapiens (P53004)
Huan, L.; Bao, C.; Chen, D.; Li, Y.; Lian, J.; Ding, J.; Huang, S.; Liang, L.; He, X.
MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-kappaB pathway to suppress cell growth in hepatocellular carcinoma cells
Cancer Sci.
107
258-266
2016
Homo sapiens
Lee, S.J.; Kang, H.K.; Eum, W.S.; Park, J.; Choi, S.Y.; Kwon, H.Y.
Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress
Cell Biol. Int.
41
514-524
2017
Homo sapiens (P53004), Homo sapiens
Chu, W.T.; Nesbitt, N.M.; Gnatenko, D.V.; Li, Z.; Zhang, B.; Seeliger, M.A.; Browne, S.; Mantle, T.J.; Bahou, W.F.; Wang, J.
Enzymatic activity and thermodynamic stability of biliverdin IXbeta reductase are maintained by an active site serine
Chemistry
23
1891-1900
2017
Homo sapiens (P30043), Homo sapiens
Zhang, M.; Song, S.; Yi, Z.; Zhao, X.; Fu, L.; Wang, L.; Ma, C.; Mao, M.; Xing, Y.; Zhu, D.
Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer
Eur. J. Pharmacol.
788
45-53
2016
Homo sapiens
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Jenkins, J.L.; Heimiller, C.; Maines, M.D.
Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation
FASEB J.
30
2926-2944
2016
Homo sapiens (P53004), Homo sapiens
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Biliverdin reductase: a target for cancer therapy?
Front. Pharmacol.
6
119
2015
Homo sapiens
Spencer, A.L.; Bagai, I.; Becker, D.F.; Zuiderweg, E.R.; Ragsdale, S.W.
Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase
J. Biol. Chem.
289
29836-29858
2014
Homo sapiens
Pallua, J.D.; Schaefer, G.; Seifarth, C.; Becker, M.; Meding, S.; Rauser, S.; Walch, A.; Handler, M.; Netzer, M.; Popovscaia, M.; Osl, M.; Baumgartner, C.; Lindner, H.; Kremser, L.; Sarg, B.; Bartsch, G.; Huck, C.W.; Bonn, G.K.; Klocker, H.
MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer
J. Proteomics
91
500-514
2013
Homo sapiens (P30043)
Takao, H.; Hirabayashi, K.; Nishigaya, Y.; Kouriki, H.; Nakaniwa, T.; Hagiwara, Y.; Harada, J.; Sato, H.; Yamazaki, T.; Sakakibara, Y.; Suiko, M.; Asada, Y.; Takahashi, Y.; Yamamoto, K.; Fukuyama, K.; Sugishima, M.; Wada, K.
A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity
Nat. Commun.
8
14397
2017
Rattus norvegicus (P06762), Homo sapiens (P53004), Synechocystis sp. PCC 6803 (P72782)
Subhanova, I.; Muchova, L.; Lenicek, M.; Vreman, H.J.; Luksan, O.; Kubickova, K.; Kreidlova, M.; Zima, T.; Vitek, L.; Urbanek, P.
Expression of biliverdin reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients
PLoS ONE
8
e57555
2013
Homo sapiens (P53004), Homo sapiens
O'Brien, L.; Hosick, P.A.; John, K.; Stec, D.E.; Hinds, T.D.
Biliverdin reductase isozymes in metabolism
Trends Endocrinol. Metab.
26
212-220
2015
Homo sapiens (P30043), Homo sapiens (P53004)
Mancuso, C.
Biliverdin reductase as a target in drug research and development Facts and hypotheses
Free Radic. Biol. Med.
172
521-529
2021
Homo sapiens (P53004), Homo sapiens
