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Literature summary for 1.3.1.24 extracted from

  • O'Brien, L.; Hosick, P.A.; John, K.; Stec, D.E.; Hinds, T.D.
    Biliverdin reductase isozymes in metabolism (2015), Trends Endocrinol. Metab., 26, 212-220.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biliverdin IXalpha + NADH + H+ Homo sapiens substrate for isoform BVRA bilirubin IXalpha + NAD+
-
 r
biliverdin IXalpha + NADPH + H+ Homo sapiens substrate for isoform BVRA bilirubin IXalpha + NADP+
-
 r
biliverdin IXbeta + NADH + H+ Homo sapiens substrate for isoform BVRB bilirubin IXbeta + NAD+
-
 r
biliverdin IXbeta + NADPH + H+ Homo sapiens substrate for isoform BVRB bilirubin IXbeta + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P30043
-
-
Homo sapiens P53004
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin IXalpha + NADH + H+ substrate for isoform BVRA Homo sapiens bilirubin IXalpha + NAD+
-
 r
biliverdin IXalpha + NADPH + H+ substrate for isoform BVRA Homo sapiens bilirubin IXalpha + NADP+
-
 r
biliverdin IXbeta + NADH + H+ substrate for isoform BVRB Homo sapiens bilirubin IXbeta + NAD+
-
 r
biliverdin IXbeta + NADPH + H+ substrate for isoform BVRB Homo sapiens bilirubin IXbeta + NADP+
-
 r

Synonyms

Synonyms Comment Organism
BVRA isoform Homo sapiens
BVRB isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform BVRA interacts with components in both the PI3-kinase/Akt and the IRK/IRS/PI3-kinase/MAPK pathyway Homo sapiens
physiological function the enzyme protects against glucose intolerance and diabetes by affecting the pancreatic islet. Isoform BVRA enhances protein kinase CbetaII localization at the cellular membrane and also modulates protein kinase Cdelta and protein kinase Czeta Homo sapiens