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Literature summary for 1.3.1.24 extracted from
- Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings (2010), Curr. Drug Targets, 11, 1586-1594.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | therapeutic potential of human BVR and human HVR-based peptides by affecting the MAPK signaling pathways, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R18Stop | a naturally occuring mutation of BVR leading to a severely truncated enzyme, liver cirrhosis and death | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin-IXa + NAD+ | Homo sapiens | - |
biliverdin-IXa + NADH + H+ | - |
? |  |
| bilirubin-IXa + NADP+ | Homo sapiens | - |
biliverdin-IXa + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| renal carcinoma cell | shows increased BVR level | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin-IXa + NAD+ | - |
Homo sapiens | biliverdin-IXa + NADH + H+ | - |
? | |
| bilirubin-IXa + NADP+ | - |
Homo sapiens | biliverdin-IXa + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BVR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NADH | - |
Homo sapiens | |
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | in HEK-293A cells, hypoxia modestly increases BVR mRNA levels | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | bilirubin is an important component of cellular defense mechanisms with cytoprotective features | Homo sapiens |
| physiological function | BVR is required for heme degradation. BVR plays a role in bile pigment metabolism, in cell protection, and in signal transduction, detailed overview. BVR reverses the inhibitory effect of biliverdin on PKC enzymes | Homo sapiens |
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Release 2023.1 (January 2023)
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