Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin + NADH + H+ | Homo sapiens | - |
bilirubin + NAD+ | - |
r | |
biliverdin + NADPH + H+ | Homo sapiens | - |
bilirubin + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
renal tumor cell | - |
Homo sapiens | - |
T-cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin + NADH + H+ | - |
Homo sapiens | bilirubin + NAD+ | - |
r | |
biliverdin + NADPH + H+ | - |
Homo sapiens | bilirubin + NADP+ | - |
r | |
additional information | protein kinase Cdelta is activated by the enzyme. Protein kinase Cdelta is not a substrate for the enzyme in vitro | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BVR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the transcript and protein levels are increased in human tumors and the infiltrating T-cells, monocytes and circulating lymphocytes, as well as the circulating and infiltrating macrophages | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the cytoprotective role of the enzyme may be permissive for cancer/tumor growth. The enzyme plays a role in transporting kinases to the membrane and nucleus and can also transport heme within the cell. The enzyme suppresses the activity of Goodpasture antigen-binding protein and hence limits the exposure of the epitope of Goodpasture antigen, thus limiting autoimmunity | Homo sapiens |