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Literature summary for 1.3.1.24 extracted from
- The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction (2010), FASEB J., 25, 301-313.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK-293A cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | inhibition of isoproterenol-induced expression of BVR using siBVR | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NAD+ | Homo sapiens | - |
biliverdin + NADH + H+ | - |
r |  |
| bilirubin + NAD+ | Rattus norvegicus | - |
biliverdin + NADH + H+ | - |
r | |
| bilirubin + NADP+ | Homo sapiens | - |
biliverdin + NADPH + H+ | - |
r | |
| bilirubin + NADP+ | Rattus norvegicus | - |
biliverdin + NADPH + H+ | - |
r | |
| additional information | Homo sapiens | BVR is an S/T/Y kinase | ? | - |
? | |
| additional information | Rattus norvegicus | BVR is an S/T/Y kinase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NAD+ | - |
Homo sapiens | biliverdin + NADH + H+ | - |
r | |
| bilirubin + NAD+ | - |
Rattus norvegicus | biliverdin + NADH + H+ | - |
r | |
| bilirubin + NADP+ | - |
Homo sapiens | biliverdin + NADPH + H+ | - |
r | |
| bilirubin + NADP+ | - |
Rattus norvegicus | biliverdin + NADPH + H+ | - |
r | |
| additional information | BVR is an S/T/Y kinase | Homo sapiens | ? | - |
? | |
| additional information | BVR is an S/T/Y kinase | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BVR | - |
Homo sapiens |
| BVR | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Rattus norvegicus | |
| NADH | - |
Homo sapiens | |
| NADH | - |
Rattus norvegicus | |
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Rattus norvegicus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview | up |
| Homo sapiens | induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview. The beta-adrenergic antagonist propranolol only slightly induces BVR expression in HEK-293A cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | isoproterenol, ISO, stimulation of BVR levels enhances the stability of heme oxygenase 2, HO-2. Interaction between HO-2 and BVR is a survival factor for cardiomyocytes during ISO stimulation | Homo sapiens |
| physiological function | blockage of BVR protein expression by retroviral siBVR inhibits the HO-2 protein induction but not vice versa | Rattus norvegicus |
| physiological function | coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival, a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction | Homo sapiens |
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