Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | BVR localizes into the nucleus upon activation by cGMP | Rattus norvegicus | |
cytokine | induces BVR transcription | Rattus norvegicus | |
Ferredoxin | - |
Arabidopsis sp. | |
heme | upregulates BVR expression | Homo sapiens | |
hyperthermia | induces BVR transcription | Rattus norvegicus | |
oxidant | activates | Homo sapiens | |
oxidant | activates | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | BVR regualtes cellular levels of biliverdin, a potent gene regulator and determinant factor for dorsal axis development in Xenopus larva | Xenopus sp. |
additional information | interacts with the insulin receptor kinase domain, key factor in the MAPK pathway and the PI3K pathway as well as regulating PKC isoforms that link the two pathways, plays a role in the mechanism of insulin resistance | Homo sapiens |
additional information | regulates oxidative response and HO-1 expression | Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
BVR-NADH complex, NH2-terminal domain in dinucleotide binding | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | changing C73 to alanine inactivates the enzyme, as it is involved in substrate/cofactor binding | Rattus norvegicus |
additional information | point mutation of residues that in BVR interact with the adenine nucleotide, all inactivate the enzyme, S149 essential for acitvity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GATA1 | transcription factor GATA1 downregulates BVR expression | Homo sapiens | |
SH-reactive agent | 34000 Da form extremely sensitive to, larger 68000 Da form lacks sensitivity to | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
converted to a larger 68000 Da form when rats are treated with SH-reactive agents | Rattus norvegicus |
68000 | - |
- |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis sp. | - |
- |
- |
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Cyanidium caldarium | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Pan troglodytes | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Takifugu rubripes | - |
- |
- |
Xenopus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | abundantly expressed | Rattus norvegicus | - |
kidney | abundantly expressed | Rattus norvegicus | - |
larva | - |
Xenopus sp. | - |
liver | - |
Cavia porcellus | - |
liver | abundantly expressed | Rattus norvegicus | - |
renal cell carcinoma cell | increased activity of BVR, but only in the presence of NADH | Homo sapiens | - |
spleen | abundantly expressed | Rattus norvegicus | - |
testis | sparingly expressed | Rattus norvegicus | - |
thymus | sparingly expressed | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin + NAD(P)H | - |
Xenopus sp. | bilirubin + NAD(P)+ | - |
? | |
biliverdin + NAD(P)H + H+ | - |
Cavia porcellus | bilirubin + NAD(P)+ | - |
? | |
biliverdin + NAD(P)H + H+ | - |
Arabidopsis sp. | bilirubin + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BVR | - |
Gallus gallus |
BVR | - |
Cavia porcellus |
BVR | - |
Cyanidium caldarium |
BVR | - |
Mus musculus |
BVR | - |
Homo sapiens |
BVR | - |
Rattus norvegicus |
BVR | - |
Sus scrofa |
BVR | - |
Canis lupus familiaris |
BVR | - |
Arabidopsis sp. |
BVR | - |
Xenopus sp. |
BVR | - |
Pan troglodytes |
BVR | - |
Takifugu rubripes |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADH | used at acidic pH | Rattus norvegicus | |
NADPH | used in the basic range | Rattus norvegicus |