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Literature summary for 1.3.1.24 extracted from

  • Florczyk, U.; Golda, S.; Zieba, A.; Cisowski, J.; Jozkowicz, A.; Dulak, J.
    Overexpression of biliverdin reductase enhances resistance to chemotherapeutics (2010), Cancer Lett., 300, 40-47.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
reversible overexpression of BVR in mouse fibroblasts, doxycycline-dependent overexpression of BVR in NIH 3T3 BVR-Tet-On cells confers protection against cytotoxic drugs cisplatin and doxorubicin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + NAD+ Homo sapiens
-
biliverdin + NADH + H+
-
r
bilirubin + NADP+ Homo sapiens
-
biliverdin + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens P53004
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NAD+
-
Homo sapiens biliverdin + NADH + H+
-
r
bilirubin + NADP+
-
Homo sapiens biliverdin + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
biliverdin reductase A
-
Homo sapiens
BVR
-
Homo sapiens
BVRA
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
with cofactor NADH Homo sapiens
8.7
-
with cofactor NADPH Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens doxycycline dose-dependently induces BVR gene expression at the level of mRNA as well as a protein, and BVR activity in genetically modified NIH 3T3 fibroblasts up

General Information

General Information Comment Organism
additional information the BVR activity and expression is not affected by MAP kinase inhibitors, overview Homo sapiens
physiological function biliverdin reductase converts biliverdin to bilirubin. Additionally, acting as a transcription factor and possessing a capacity of a serine/threonine kinase, it may modulate signaling pathways. BVR exhibits cytoprotection, important role of PKCa/b kinase in BVR-mediated improvement in cell survival Homo sapiens