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Literature summary for 1.3.1.24 extracted from

  • Florczyk, U.M.; Jozkowicz, A.; Dulak, J.
    Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance (2008), Pharmacol. Rep., 60, 38-48.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Localization

Localization Comment Organism GeneOntology No. Textmining
caveola
-
 Rattus norvegicus 5901
-
caveola
-
 Homo sapiens 5901
-
mitochondrial membrane
-
 Rattus norvegicus 31966
-
mitochondrial membrane
-
 Homo sapiens 31966
-
nucleus in the nucleus, BVR is a leucine zipper-like DNA binding protein and can act as a transcription factor for activator protein 1-regulated genes Rattus norvegicus 5634
-
nucleus in the nucleus, BVR is a leucine zipper-like DNA binding protein and can act as a transcription factor for activator protein 1-regulated genes Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 BVRB, SDS-PAGE Rattus norvegicus
21000
-
 BVRB, SDS-PAGE Homo sapiens
33500
-
 BVRA, SDS-PAGE Rattus norvegicus
33500
-
 BVRA, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30043
-
-
Homo sapiens P53004
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus P46844
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin IXalpha + NAD(P)H + H+ substrate of BVRA but not of BVRB isoform Rattus norvegicus bilirubin IXalpha + NAD(P)+
-
 ir
biliverdin IXalpha + NAD(P)H + H+ substrate of BVRA but not of BVRB isoform Homo sapiens bilirubin IXalpha + NAD(P)+
-
 ir
insulin receptor substrate 1 + NAD(P)H phosphorylates serine residues in insulin receptor substrate 1 Rattus norvegicus ?
-
 ?
insulin receptor substrate 1 + NAD(P)H phosphorylates serine residues in insulin receptor substrate 1 Homo sapiens ?
-
 ?
additional information biliverdin IXalpha is no substrate BVRB isoform Homo sapiens ?
-
 ?
additional information biliverdin IXalpha is no substrate of BVRB isoform Rattus norvegicus ?
-
 ?
additional information BVR has also serine/threonine/tyrosine kinase activity Rattus norvegicus ?
-
 ?
additional information BVR has also serine/threonine/tyrosine kinase activity Homo sapiens ?
-
 ?
additional information BVR is a substrate for insulin receptor tyrosine kinase Rattus norvegicus ?
-
 ?
additional information BVR is a substrate for insulin receptor tyrosine kinase Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 21000, BVRB, SDS-PAGE Rattus norvegicus
monomer 1 * 21000, BVRB, SDS-PAGE Homo sapiens
monomer 1 * 33500, BVRA, SDS-PAGE Rattus norvegicus
monomer 1 * 33500, BVRA, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
BVRA isoform Rattus norvegicus
BVRA isoform Homo sapiens
BVRB isoform, predominant during fetal development Rattus norvegicus
BVRB isoform, predominant during fetal development Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
 optimal pH value for NADH as cofactor Rattus norvegicus
6.7
-
 optimal pH value for NADH as cofactor Homo sapiens
8.7
-
 optimal pH value for NADPH as cofactor Rattus norvegicus
8.7
-
 optimal pH value for NADPH as cofactor Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)H
-
 Rattus norvegicus
NAD(P)H
-
 Homo sapiens