Literature summary for 1.3.1.24 extracted from

Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Tudor, C.; Hagen, F.K.; Maines, M.D.
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C (2012), J. Biol. Chem., 287, 24698-24712.

Search for more literature for 1.3.1.24

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C281A/C292A/C293A	C-terminal fragment 272-296 in which cysteine residues are replaced by alanine do not interact with Goodpasture antigen-binding protein whereas wild-type C-terminal fragment 276-296 does	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	hBVR binds to Goodpasture antigen-binding protein and down-regulates its TNF-alpha-stimulated kinase activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	hBVR binds to Goodpasture antigen-binding protein and down-regulates its TNF-alpha-stimulated kinase activity	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
biliverdin reductase	-	Homo sapiens
hBVR	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	hBVR suppresses Goodpasture antigen-binding protein autophosphorylation in a concentration-dependent manner. The inhibitory effect of hBVR on GPBP kinase activity extended to its ability to phosphorylate its substrate, GPA-derived peptide	Homo sapiens
physiological function	TNF-alpha alpha-NF-kappaB-dependent expression of Goodpasture antigen-binding protein is regulated by biliverdin reductase	Homo sapiens

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Release 2023.1 (January 2023)