Information on EC 6.4.1.2 - acetyl-CoA carboxylase

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria

EC NUMBER
COMMENTARY
6.4.1.2
-
RECOMMENDED NAME
GeneOntology No.
acetyl-CoA carboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
ordered bi bi uni uni ping-pong mechanism
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
ordered mechanism
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
non-ordered ter ter mechanism
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
substrate specificity, catalytic mechanism, and structural features
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
catalytic regions analysis
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
two-step reaction mechanism, structure-activity relationship
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
molecular surface of the active site of the carboxyltransferase domain
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
the enzyme proceeds through a hybrid (two-site) random Ter Ter mechanism, one that likely involves a two-step reaction at the biotin carboxylase domain
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
catalytic regions analysis
Caenorhabditis elegans W09B6
-
-
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
Rhizobium etli 12-53
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
carboxylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
3-hydroxypropionate cycle
-
3-hydroxypropionate/4-hydroxybutyrate cycle
-
Aflatoxin biosynthesis
-
Biosynthesis of secondary metabolites
-
biotin-carboxyl carrier protein assembly
-
Carbon fixation pathways in prokaryotes
-
Fatty acid biosynthesis
-
fatty acid biosynthesis initiation I
-
glyoxylate assimilation
-
jadomycin biosynthesis
-
Metabolic pathways
-
Microbial metabolism in diverse environments
-
octanoyl-ACP biosynthesis (mitochondria, yeast)
-
Propanoate metabolism
-
Pyruvate metabolism
-
Tetracycline biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:carbon-dioxide ligase (ADP-forming)
A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ACACA
Q2HXS0
-
ACC
-
-
ACC
Caenorhabditis elegans W09B6
-
-
-
ACC
-
structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACC
Escherichia coli MG1655
-
-
-
ACC
O00763, Q13085
-
ACC
Magnaporthe grisea Guy11
-
-
-
ACC
Q5SWU9, Q6JIZ0
-
ACC
Mus musculus C57BL/6J
-
-
-
ACC
-
-
ACC
O70151, P11497
-
ACC
Rhizobium etli 12-53
-
-
-
ACC
-
structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACC
Q12721
-
ACC-1
Q13085
-
ACC1
-
or ACACA, isoform
ACC1
Q13085
-
ACC1
-
-
ACC1
-
isoform
Acc1p
Saccharomyces cerevisiae X2180-1A
-
-
-
ACC2
-
or ACACB, isoform
ACC2
-
isoform
AccA
Q13085
-
ACCalpha
Q13085
-
ACCase
-
-
-
-
ACCase
-
-
ACCase
-
-
ACCase
-
-
ACCase
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10
-
ACCase
-
-
ACCase
-
the ACCase that preferentially accepts acetyl-CoA as a substrate is defined as an acetyl-CoA carboxylase (ACC)
ACCase 1
Q38971
-
ACCB
-
-
Acetyl CoA carboxylase
-
-
-
-
Acetyl CoA carboxylase
-
-
Acetyl coenzyme A carboxylase
-
-
-
-
acetyl coenzyme A carboxylase alpha
Q13085
-
acetyl-CoA carboxylase 1
Q38971
-
acetyl-CoA carboxylase 1
-
-
acetyl-CoA carboxylase 1
-
-
acetyl-CoA carboxylase 2
-
-
acetyl-CoA carboxylase 2
O00763
-
acetyl-CoA carboxylase 2
-
-
acetyl-CoA carboxylase 2
-
-
acetyl-CoA carboxylase A
-
-
acetyl-CoA carboxylase alpha
Q13085
-
acetyl-CoA carboxylase B
-
-
acetyl-CoA carboxylase-2
-
-
acetyl-CoA carboxylase-alpha
Q2HXS0
-
acetyl-CoA-carboxylase
-
-
acetyl-CoA/propionyl-CoA carboxylase
-
enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
Chloroflexus aurantiacus OK-70-fl
-
enzyme acts on both substrates
-
acetyl-CoA/propionyl-CoA carboxylase
Q8J2Z5
enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
Metallosphaera sedula TH2
Q8J2Z5
enzyme acts on both substrates
-
acetyl-CoA/propionyl-CoA carboxylase
-
enzyme acts on both substrates
Acetyl-coenzyme A carboxylase
-
-
-
-
Acetyl-coenzyme A carboxylase
-
-
Acetyl-coenzyme A carboxylase
O00763, Q13085
-
acetyl-coenzyme-A carboxylase
-
-
acetylCoA carboxylase
-
-
BCCP1
-
ACCase subunit
BCCP1
-
subunit
BCCP2
-
ACCase subunit
BCCP2
-
subunit
CAC1A
-
gene name for subunit BCCP1
CAC1B
-
gene name for subunit BCCP2
Carboxylase, acetyl coenzyme A
-
-
-
-
Hfa1p
Saccharomyces cerevisiae X2180-1A
-
-
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
Caenorhabditis elegans W09B6
-
the enzyme belongs to the family of biotin-dependent carboxylases
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
O00763, Q13085
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
Q5SWU9, Q6JIZ0
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
O70151, P11497
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
c.f. EC 6.4.1.3
additional information
Rhizobium etli 12-53
-
c.f. EC 6.4.1.3
-
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
-
the enzyme belongs to the family of biotin-dependent carboxylases
CAS REGISTRY NUMBER
COMMENTARY
9023-93-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Q877I4: biotin carboxyl carrier protein of acetyl-CoA carboxylase, Q877I3: carboxyltransferase subunit of acetyl-CoA carboxylase, Q877I5: biotin carboxylase subunit of acetyl-CoA carboxylase
Q877I4 and Q877I3 and Q877I5
UniProt
Manually annotated by BRENDA team
strain So4a, DSM 3191
-
-
Manually annotated by BRENDA team
Acidianus infernus So4a
strain So4a, DSM 3191
-
-
Manually annotated by BRENDA team
'Notts-A1'-resistant biotype and strain Rothamsted
-
-
Manually annotated by BRENDA team
84 French black-grass field samples
-
-
Manually annotated by BRENDA team
black grass, an arable weed, 297 populations distributed across six countries in central Europe and the Turkey
-
-
Manually annotated by BRENDA team
seed samples collected across France
-
-
Manually annotated by BRENDA team
-
Q38971
SwissProt
Manually annotated by BRENDA team
isozyme ACC1
-
-
Manually annotated by BRENDA team
strain W09B6
-
-
Manually annotated by BRENDA team
Caenorhabditis elegans W09B6
strain W09B6
-
-
Manually annotated by BRENDA team
strain OK-70-fl, DSM 636
-
-
Manually annotated by BRENDA team
strain OK-70fl, DSM 636
-
-
Manually annotated by BRENDA team
Chloroflexus aurantiacus OK-70-fl
strain OK-70-fl, DSM 636
-
-
Manually annotated by BRENDA team
Chloroflexus aurantiacus OK-70fl
strain OK-70fl, DSM 636
-
-
Manually annotated by BRENDA team
single gene
-
-
Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
zebrafish
-
-
Manually annotated by BRENDA team
herbicide-sensitive and herbicide-resistant biotypes
-
-
Manually annotated by BRENDA team
strain MG1655
-
-
Manually annotated by BRENDA team
Escherichia coli MG1655
strain MG1655
-
-
Manually annotated by BRENDA team
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
-
-
Manually annotated by BRENDA team
2 lines of seeds: 9686 and Wayne
-
-
Manually annotated by BRENDA team
cv. Lambert
-
-
Manually annotated by BRENDA team
2 isoforms ACC1 and ACC2
SwissProt
Manually annotated by BRENDA team
female and male individuals
SwissProt
Manually annotated by BRENDA team
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
Manually annotated by BRENDA team
isozyme ACC2; gene ACACA, encoding isozyme ACC1 or ACC-alpha, and gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
Manually annotated by BRENDA team
isozymes ACC1 and ACC2
-
-
Manually annotated by BRENDA team
two isozymes Acc1 and Acc2
-
-
Manually annotated by BRENDA team
Chinese sprangletop
-
-
Manually annotated by BRENDA team
diclofop-resistant and diclofop-susceptible biotype
-
-
Manually annotated by BRENDA team
herbicide resistant strain AUS93
-
-
Manually annotated by BRENDA team
herbicide sensitive wild type
SwissProt
Manually annotated by BRENDA team
slighly different sequences found in different plants; herbicide resistant strain AUS92
Q94FR9, Q94FS0, Q94FS1
SwissProt
Manually annotated by BRENDA team
strain Guy11
-
-
Manually annotated by BRENDA team
Magnaporthe grisea Guy11
strain Guy11
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain TH2, DSM 5348
SwissProt
Manually annotated by BRENDA team
strain TH2, DSM 5348
-
-
Manually annotated by BRENDA team
Metallosphaera sedula TH2
strain TH2, DSM 5348
SwissProt
Manually annotated by BRENDA team
Metallosphaera sedula TH2
strain TH2, DSM 5348
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
C57BL/6J mice
-
-
Manually annotated by BRENDA team
C57BL/6J mice, isozymes ACC1 and ACC2
-
-
Manually annotated by BRENDA team
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
SwissProt
Manually annotated by BRENDA team
isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
SwissProt
Manually annotated by BRENDA team
male C57Bl6/J mice, isozymes ACC1 and ACC2
-
-
Manually annotated by BRENDA team
male mice
-
-
Manually annotated by BRENDA team
two isozymes Acc1 and Acc2
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
-
-
Manually annotated by BRENDA team
genotype US-1
SwissProt
Manually annotated by BRENDA team
Pigeon
-
-
-
Manually annotated by BRENDA team
cv. Alaska, light and dark-adapted plants
-
-
Manually annotated by BRENDA team
wild type BC1/7 RR and mutant BC1/7 rr
-
-
Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
insulin resistant strain JCR:LA-cp and wild type rats
-
-
Manually annotated by BRENDA team
isozyme ACC1; gene ACACA, encoding isozyme ACC1 or ACC-alpha
GenBank
Manually annotated by BRENDA team
isozyme ACC2; gene ACACB, encoding isozyme ACC2 or ACC-beta
GenBank
Manually annotated by BRENDA team
male Fischer rats
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Sprangue-Dawley rats
-
-
Manually annotated by BRENDA team
male Wistar Hannover rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
obese Zucker rat
-
-
Manually annotated by BRENDA team
two isozymes Acc1 and Acc2
-
-
Manually annotated by BRENDA team
strain 12-53, the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-
-
Manually annotated by BRENDA team
Rhizobium etli 12-53
strain 12-53, the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
-
-
Manually annotated by BRENDA team
strain X2180-1A, genes HFA1 and ACC1
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae X2180-1A
strain X2180-1A, genes HFA1 and ACC1
-
-
Manually annotated by BRENDA team
herbicide-sensitive and herbicide-resistant biotypes
-
-
Manually annotated by BRENDA team
cv. Desiree
-
-
Manually annotated by BRENDA team
strain Krs23, DSM 6482
-
-
Manually annotated by BRENDA team
Sulfolobus metallicus Krs23
strain Krs23, DSM 6482
-
-
Manually annotated by BRENDA team
puffer fish
-
-
Manually annotated by BRENDA team
strain RH
Q9U755
SwissProt
Manually annotated by BRENDA team
strain RH
Q9U755
SwissProt
Manually annotated by BRENDA team
2 isoforms: non-mesophyll chloroplast form and mesophyll chloroplast form
-
-
Manually annotated by BRENDA team
herbicide sensitive strain; slightly different sequences found in different plants; herbicide resistant strain DK592
SwissProt
Manually annotated by BRENDA team
major isoform ACCase 1 and a minor isoform ACCase 2
-
-
Manually annotated by BRENDA team
slightly different sequences found in different plants; herbicide resistant strain DK592
Q94FR6, Q94FR7
SwissProt
Manually annotated by BRENDA team
Zea mays sensitive
herbicide sensitive strain
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
-
inhibition of ACC1 through either RNA interference or inhibitor treatment (0.01 mg/ml 5-tetradecyloxy-2-furoic acid) attenuates human cytomegalovirus replication
malfunction
-
in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection
malfunction
-
transfer DNA insertional alleles that completely eliminate the accumulation of subunit BCCP2 have no perceptible effect on plant growth, development, and fatty acid accumulation. In contrast, transfer DNA insertional null allele of the CAC1A gene for subunit BCCP1 is embryo lethal and deleteriously affects pollen development and germination. Reducing BCCP1 accumulation to 35% of wild type levels, decreases fatty acid accumulation and severely affects normal vegetative plant growth
metabolism
-
acetyl-CoA carboxylase is the rate limiting enzyme in de novo lipid synthesis
metabolism
-
ACC1 is the rate-limiting enzyme of fatty acid biosynthesis
metabolism
-
ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons
metabolism
-
ACCase is a key enzyme for de novo fatty acid biosynthesis
physiological function
-
acetyl-CoA carboxylase plays important roles in modulating energy metabolism
physiological function
-
ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice
physiological function
-
ACCase is essential for plant seed development
physiological function
-
ACCase is a key enzyme initiating the synthesis of fatty acids in plastids
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetodethio-CoA + HCO3-
?
show the reaction diagram
-
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, O00763
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
P11497
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Pigeon
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
-
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q94FR5, Q94FR6, Q94FR7
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q94FR8, Q94FR9, Q94FS0, Q94FS1
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q13085
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
O00763
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U755, -
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U753
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U752
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q9U751
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q2HXS0
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
absolute specificity for acetyl-CoA
-
-
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q94FR8, Q94FR9, Q94FS0, Q94FS1
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q94FR5, Q94FR6, Q94FR7
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q13085
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
ACC catalyzes the first committed step in the synthesis of long-chain fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
ACC plays an important role in energy balance by controlling malonyl-CoA synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q877I4 and Q877I3 and Q877I5
the bifunctional enzyme also catalyzes the carboxylation of propionyl-CoA. Vmax/Km for carboxylation of propanoyl-CoA is 1.6fold higher than Vmax/Km for carboxylation of acetyl-CoA. Quite specific for ATP. No activity with ADP, AMP, GTP, CTP, UTP, or dTTP (0.2 mM)
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U755
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-, key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Chloroflexus aurantiacus OK-70-fl
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Zea mays sensitive
Q94FR5
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Chloroflexus aurantiacus OK70-fl
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Acidianus infernus So4a
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Sulfolobus metallicus Krs23
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Mus musculus C57BL/6J
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Sulfolobus metallicus Kra23
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Chloroflexus aurantiacus OK-70fl
-
-, no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
-
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key role in lipid metabolism
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key enzyme of 3-hydroxypropionate cycle
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
catalyzes the first committed step in the synthesis of fatty acids
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key enzyme of de nove fatty acid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
Q877I4 and Q877I3 and Q877I5
n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
r
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q12721
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-, Q6SZP8
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O00763, Q13085
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O70151, P11497
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q5SWU9, Q6JIZ0
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by pH, redox, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
hormonal, nutrient, and tissue-specific regulation of ACC genes, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme activity is involved in biosynthesis of fatty acids as well as polyketids, which are precursors of pharmaceutically important antibiotics, anticancer agents and other drugs
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme activity is limiting for lipid synthesis in tubers, biosynthetic pathway and regulatory aspects, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q12721
the enzyme catalyzes the first step in fatty acid bioynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme is essential for viability
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O00763, Q13085
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O70151, P11497
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q5SWU9, Q6JIZ0
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
wild-type enzyme, transcarboxylation between biotin and acetyl-CoA is catalyzed by the core catalytic beta-subunit
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Saccharomyces cerevisiae X2180-1A
-
-, enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Rhizobium etli 12-53
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Escherichia coli MG1655
-
-, first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Caenorhabditis elegans W09B6
-
regulation of isozyme expression and activity, the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Magnaporthe grisea Guy11
-
-
-
-
?
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-, malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + biotin + HCO3-
ADP + ? + phosphate
show the reaction diagram
-
free biotin can be used as carboxyl acceptor with low activity
-
-
?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
r
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
-
no activity
-
-
-
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
-
no activity
-
-
-
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
-
60% of the activity relative to acetyl-CoA
-
-
-
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
-
15% of the activity relative to acetyl-CoA
-
-
-
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
-
wild-type enzyme
-
-
?
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
Rhizobium etli 12-53
-
-
-
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
no activity
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
no activity
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
60% of the activity relative to acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
45% of the activity compared to acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
maximal rate is 20% of that for acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
maximal rate is 20% of that for acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
13% of the activity relative to acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
-
10% of the activity relative to acetyl-CoA
-
-
-
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
second activity of the protein representing EC 6.4.1.3
-
?
ATP + propionyl-CoA + HCO3-
ADP + methylmalonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
r
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
-
highly preferred substrate, participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
-
wild-type and mutant I420D enzyme
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
Rhizobium etli 12-53
-
highly preferred substrate
-
-
?
dATP + acetyl-CoA + HCO3-
dADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
-
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
10% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
show the reaction diagram
-
at 2.5% of the activity relative to ATP
-
-
-
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
40% of the activity obtained with ATP
-
?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
40% of the activity obtained with ATP
-
?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
10% of the activity obtained with ATP
-
?
additional information
?
-
Q38971
ACCase 1 is essential for correct plant development
-
-
-
additional information
?
-
-
isozymes ACC1 and ACC2 play roles in lipid metabolism in adipose tissue, overview
-
-
-
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
-
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
-
additional information
?
-
-
acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that catalyzes the first committed and regulated step in fatty acid biosynthesis in bacteria via a two-step reaction. Biotin carboxylase, EC 6.3.4.14, catalyzes the first half-reaction, which is an ATP-dependent carboxylation of biotin to form carboxybiotin. The second half-reaction is catalyzed by carboxyltransferase, EC 6.4.1.2, which transfers the carboxyl group from carboxybiotin to acetyl-CoA to generate malonyl-CoA
-
-
-
additional information
?
-
-
perinatal copper deficiency in rat pups inhibits the enzyme, overview
-
-
-
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
-
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
-
additional information
?
-
-
structure-activity relationship, overview
-
-
-
additional information
?
-
Q877I4 and Q877I3 and Q877I5
neither succinyl-CoA, palmitoyl-CoA, acetate (plus 0.5 mM CoASH), propionate (plus 0.5 mM CoASH), nor pyruvate is carboxylated by the enzyme
-
-
-
additional information
?
-
Rhizobium etli 12-53
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
P11497
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U755, -
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U753
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U752
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q9U751
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q2HXS0
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
r
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-, Q94FR8, Q94FR9, Q94FS0, Q94FS1
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q94FR5, Q94FR6, Q94FR7
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q13085
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q8J2Z4, Q8J2Z5
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
ACC catalyzes the first committed step in the synthesis of long-chain fatty acids
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
ACC plays an important role in energy balance by controlling malonyl-CoA synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
intracellular citrate controls ACC activity and malonyl-CoA levels, and diminishes food intake, physiological regulation system involving citrate, overview
-
-
?
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
-
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key role in lipid metabolism
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key enzyme of 3-hydroxypropionate cycle
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
catalyzes the first committed step in the synthesis of fatty acids
-
-
-
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
-
key enzyme of de nove fatty acid biosynthesis
-
-
-
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-, Q6SZP8
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
biological function, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O00763, Q13085
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
O70151, P11497
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q5SWU9, Q6JIZ0
first committed step in fatty acid biosynthesis, hormonal, nutrient, and tissue-specific regulation of ACC genes, regulation of isozyme activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological role, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by pH, redox, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
hormonal, nutrient, and tissue-specific regulation of ACC genes, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
regulation of isozyme expression and activity, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme activity is involved in biosynthesis of fatty acids as well as polyketids, which are precursors of pharmaceutically important antibiotics, anticancer agents and other drugs
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme activity is limiting for lipid synthesis in tubers, biosynthetic pathway and regulatory aspects, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Q12721
the enzyme catalyzes the first step in fatty acid bioynthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme influences the fatty acid oxidation, body weight, and body fat levels, isozyme Acc1 catalyzes the committed and rate-determining step in the biosynthesis of long-chain fatty acids, while isozyme Acc2 produces a potent inhibitor of fatty acid oxidation, biological functions, regulation of enzyme activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
-
the enzyme is essential for viability
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Q9U755
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Chloroflexus aurantiacus OK-70-fl
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Zea mays sensitive
Q94FR5
key enzyme of fatty acid biosynthesis
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Chloroflexus aurantiacus OK70-fl
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Saccharomyces cerevisiae X2180-1A
-
enzymes Hfa1p and Acc1p are involved in mitochondrial and cytoplasmic fatty acid synthesis, respectively, Hfa1p is responsible for production of malonyl-CoA for intraorganellar fatty acid and lipoic acid synthesis
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Metallosphaera sedula TH2
Q8J2Z4, Q8J2Z5
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Acidianus infernus So4a
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Rhizobium etli 12-53
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Sulfolobus metallicus Krs23
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Escherichia coli MG1655
-
first step in fatty acid biosynthesis via fatty acid synthase type II, overview
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Caenorhabditis elegans W09B6
-
regulation of isozyme expression and activity
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Mus musculus C57BL/6J
-
-
-
-
ir
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
Magnaporthe grisea Guy11
-
-
-
-
?
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
Sulfolobus metallicus Kra23, Chloroflexus aurantiacus OK-70fl
-
no fatty acid synthesis, involved in 3-hydroxypropionate cycle for autotrophic CO2 fixation
-
?
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
show the reaction diagram
-
-
malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
-
ir
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
Rhizobium etli, Rhizobium etli 12-53
-
-
-
-
?
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
-
participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
-
-
?
additional information
?
-
Q38971
ACCase 1 is essential for correct plant development
-
-
-
additional information
?
-
-
isozymes ACC1 and ACC2 play roles in lipid metabolism in adipose tissue, overview
-
-
-
additional information
?
-
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
-
additional information
?
-
-
the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity
-
-
-
additional information
?
-
-
acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that catalyzes the first committed and regulated step in fatty acid biosynthesis in bacteria via a two-step reaction. Biotin carboxylase, EC 6.3.4.14, catalyzes the first half-reaction, which is an ATP-dependent carboxylation of biotin to form carboxybiotin. The second half-reaction is catalyzed by carboxyltransferase, EC 6.4.1.2, which transfers the carboxyl group from carboxybiotin to acetyl-CoA to generate malonyl-CoA
-
-
-
additional information
?
-
-
perinatal copper deficiency in rat pups inhibits the enzyme, overview
-
-
-
additional information
?
-
-
regulation of ACC is necessary for maintaining the energy balance
-
-
-
additional information
?
-
-
the enzyme interacts with the BRCA1 protein, that is involved in multiple cellular functions, BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction, the interaction between BRCA1 and ACCA is regulated during cell cycle progression, increased interaction occurs when the cells progress to G2/M, overview
-
-
-
additional information
?
-
Rhizobium etli 12-53
-
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
ATP
-
dependent on
ATP
Q5SWU9, Q6JIZ0
;
ATP
O70151, P11497
;
biotin
-
covalent attachment of the biotin prosthetic group
biotin
-
covalent attachment of the biotin prosthetic group
biotin
-
contains 1 mol of biotin per 263000 g of protein
biotin
-
contains 1 mol of biotin per 237000 g of enzyme
biotin
-
contains 1 mol biotin per 480000 g of protein
biotin
-
contains 1 mol biotin per 240000 g of enzyme
biotin
-
contains 0.91 mol of biotin per dimer of MW 215000
biotin
-
conformational change accompanies biotinylation of the biotin domain
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
Q9U753
enzyme-bound
biotin
Q9U752
enzyme-bound
biotin
-, Q9U751
enzyme-bound
biotin
Q9U755
enzyme-bound
biotin
-, Q94FR8, Q94FR9, Q94FS0, Q94FS1
enzyme-bound
biotin
-
enzyme-bound
biotin
-
enzyme-bound
biotin
Q12721
covalently bound prosthetic group, required for activity
biotin
-
transcarboxylation between biotin and acetyl-CoA catalyzed by the core catalytic beta-subunit
biotin
-
dependent on
biotin
O00763, Q13085
;
biotin
Q5SWU9, Q6JIZ0
;
biotin
O70151, P11497
;
biotin
-
dependent on
biotin
-
dependent on, bound by the biotin carboxyl carrier protein
biotin
-
dependent on
biotin
-
ACC2 is a biotinylated enzyme
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
Q8J2Z4, Q8J2Z5
can partially replace for Mg2+
Co2+
Q8J2Z4, Q8J2Z5
can partially replace for Mg2+
Co2+
Q877I4 and Q877I3 and Q877I5
26% of the maximum activity is observed when Co2+ (10 to 15 mM) is used as a divalent cation
Cs+
-
greater activation at 1 mM HCO3- than at 10 mM HCO3-
Cs+
-
small activating effect, depends on the degree of saturation of the reaction by HCO3-
Cs+
-
dependent on
Cu2+
-
inhibitory for forward reaction, stimulates reverse reaaction
Fe2+
-
stimulates activity
Fe3+
-
stimulates activity
K+
-
greatest activation at 12-15 mM K+, at HCO3- concentration of 0.18 mM, 1 mM, and 10 mM
K+
-
small activating effect, depends on the degree of saturation of the reaction by HCO3-
K+
-
activates
K+
-
dependent on
Mg2+
-
essential activator; optimal concentration of 9686 enzyme: 5 mM, optimal concentration of Wayne enzyme: 3 mM
Mg2+
-
free Mg2+ activates; maximal activity at 3 mM Mg2+ with 1 mM ATP and at 4 mM Mg2+ with 3 mM ATP
Mg2+
-
both MgATP2- and free Mg2+ required. Maximal activation at 5 mM Mg2+; Mg2+ or Mn2+ essential for activity
Mg2+
-
maximal activation when ATP exists largely as MgATP2- with low concentrations of free Mg2+
Mg2+
-
about 10 mM Mg2+ required for maximal activity, inhibition above 15 mM
Mg2+
-
concentration of Mg2+ must be sufficient to allow chelation by both ATP and citrate. Free Mg2+ inhibits
Mg2+
-
activates
Mg2+
-
Mg2+ or Mn2+ essential for activity
Mg2+
-
maximal activity at 2 mM Mg2+ in presence of 1 mM ATP
Mg2+
Q8J2Z4, Q8J2Z5
required to form a complex with ATP
Mg2+
Q12721
-
Mg2+
-
absolutely required for activity
Mg2+
Q2HXS0
-
Mg2+
-
dependent on
Mg2+
Q877I4 and Q877I3 and Q877I5
maximum acetyl-CoA carboxylase activity is obtained at 4.0 mM
Mn2+
-
no effect
Mn2+
-
maximal activity at 1 mM Mn2+ with 1 mM ATP. Maximal activity is 25% of that observed with Mg2+
Mn2+
-
Mn2+ or Mg2+ essential for activity. Maximal activation at 1.5 mM Mn2+
Mn2+
-
activates; maximal activity at 8 mM
Mn2+
-
20% of activation relative to Mg2+, at 2 mM
Mn2+
Q8J2Z4, Q8J2Z5
can partially replace for Mg2+
NH4+
-
greater activation at 1 mM HCO3- than at 10 mM HCO3-
NH4+
-
dependent on
phosphate
-
phosphate content of the 10000000 MW enzyme form: 4.0 mol of phosphate per mol of subunit. Phosphate content of the 2000000 MW enzyme form: 6.0 mol phosphate per mol of subunit. The 10000000 MW subunit and the 2000000 MW subunit are interconvertible by phosphorylation and dephosphorylation. Dephosphorylation by [acetyl-CoA carboxylase]-phosphatase 2 activates the enzyme and reduces its dependence on citrate
phosphate
-
contains 2.1 mol phosphate per 215000 g of protein
phosphate
-
contains 3.2 mol of phosphate per mol of subunit
phosphate
-
contains approximately 6 mol phosphate per 240000 g of protein
phosphate
-
contains 9.83 mM of phosphate per mg of protein
phosphate
-
dephosphorylation does not result in activation
Zn2+
-
inhibitory for forward reaction, stimulates reverse reaaction
Mn2+
Q877I4 and Q877I3 and Q877I5
1.0 mM Mn2+ gives 82% of the maximum activity obtained with the Mg2+ ion
additional information
-
the zinc domain in bacterial carboxyltransferase belongs to the zinc ribbon class of zinc fingers, Zn domains are commonly associated with DNA binding
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(+)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid
-
;
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
-
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
-
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
-
-
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM, for the wild-type enzyme in crude extract 11 nM
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM, for the wild-type enzyme in crude extract 288 nM
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-6-morpholin-4-yl-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
7% inhibition at 0.01 mM
1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
16% inhibition at 0.01 mM
1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
51% inhibition at 0.005 mM
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
-
i.e. CP-640186 or bispiperidylcarboxamide derivative I with a tricyclic hydrophobic core, shows inhibition of both ACC1 and ACC2
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
44% inhibition at 0.01 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-(1H-1,2,4-triazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(4,8-dimethoxyquinolin-2-yl)carbonyl]-6-[(1-methyl-1H-pyrazol-5-yl)amino]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
complete inhibition at 0.005 mM
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-(4-[[2-amino-6-(trifluoromethyl)-1-benzothiophen-3-yl]carbonyl]piperazin-1-yl)piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
-
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
-
-
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
-
-
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
-
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
-
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
-
-
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
-
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
-
-
1-ethyl-3-[3-[(4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1-benzothiophen-2-yl]urea
-
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
-
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
-
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
-
-
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
-
-
-
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea maleate
-
-
-
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
-
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
-
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
2'-tert-butyl-1-(1H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]-methyl)cyclohexyl]methyl]carbamate
-
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
2-(4-Chlorophenoxy)-2-methylpropionate
-
-
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
2-methoxy-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
-
2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]propionic acid
-
-
2-methyl-N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
-
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
3,3,14,14-tetramethylhexadecanedioic acid
-
-
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
-
-
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
-
-
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
-
-
4-Bromo-2,3-dioxobutyl-CoA
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
-
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
-
-
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
-
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
-
5-(tetradecyloxy)-2-furancarboxylic acid
-
;
5-(tetradecyloxy)-2-furoic acid
P11497
an ACC1 inhibitor e.g. in beta cells
5-(tetradecyloxy)-2-furoic acid
-
a hypolipidemic agent
5-(tetradecyloxy)-2-furoyl-CoA
-
-
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
5-tetradecyloxy-2-furoic acid
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
-
5-[1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]pyridine-3-carboxylic acid
-
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-1H-indole-3-carbonitrile
-
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM, for the wild-type enzyme in crude extract 8 nM
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
6-morpholin-4-yl-1'-(10H-phenothiazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
64% inhibition at 0.01 mM
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
-
;
A-919658
-
-
-
Acyl carrier protein
-
acylated derivatives, acyls with chain lengths from C6:0 to C20:1 are inhibitory, 0.04 mM results in 60-70% inhibition, complete inhibition not achieved even with very high concentrations
ADP
Q8J2Z4, Q8J2Z5
-
AMP
-
slight
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
i.e. CP-640186
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
-
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
-
-
Arachidonoyl-CoA
-
-
arachidoyl-CoA
-
-
ATP
-
competitive inhibition versus ADP
ATP
Q877I4 and Q877I3 and Q877I5
above 2.0 mM
Avidin
-
biotin prevents inhibition
-
Avidin
-
-
-
Avidin
-
-
-
Avidin
Q8J2Z4, Q8J2Z5
reversible by addition of biotin
-
Avidin
-
complete inhibition at 1 nM
-
Avidin
-
0.001 mM
-
Avidin
-
general inhibitor of ACCase activity
-
beta,beta'-Tetramethyl-substituted hexadecanedioic acid
-
i.e. MEDICA, dead-end inhibitor
beta,beta,beta',beta'-tetramethylhexadecanoic acid
-
;
BODIPY-soraphen A
-
a soraphen A derivative, shows high activity against ACC2, synthesis, overview. BODIPY-soraphen A directly binds to the BC domain of the ACC enzyme by causing a 10C increase in thermal stability of the protein using a differential scanning calorimetry assay
BRCA1 protein
-
BRCA1 reduces acetyl-CoA-carboxylase alpha, ACCA, activity through its phospho-dependent binding to ACCA, the phosphorylation of the Ser1263 of ACCA is required for this interaction
-
butroxydim
-
-
chloroacetylated biotin derivative
-
80% inhibition
-
citrate
-
10 mM
citrate
-
9686 enzyme: below 3 mM no effect, inhibition above. Wayne enzyme: slight stimulation up to 5 mM, strong inhibition above
citrate
-
stimulates at 2 mM, inhibits at higher concentrations
citrate
-
above 4.0 mM
citrate
Q877I4 and Q877I3 and Q877I5
3 mM, more than 50% inhibition
Clethodim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
Q9U755
-
Clodinafop
-
-
Clodinafop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Clodinafop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
CoA
-
inhibition requires the presence of MgATP2-, but is independent of phosphorylation of the enzyme, the effect is complete in about 5 min and is associated with depolymerization of acetyl-CoA carboxylase, half-maximal inhibition at 0.04 mM CoA, inhibition is partially reversed by incubation with citrate and more fully overcome by treatment of the enzyme with the insulin-stimulated acetyl-CoA carboxylase
CoA
Q8J2Z4, Q8J2Z5
-
CoA
Q877I4 and Q877I3 and Q877I5
1 mM, 11-13% inhibition of acetyl-CoA carboxylase
coenzyme A-carboxybiotin
-
coenzyme A is covalently attached to carboxybiotin, bisubstrate inhibitor
CP-640186
-
inhibition of both isozymes Acc1 and Acc2, an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
an anthracene fluorophore, probably binds to the biotin binding site
CP-640186
-
herbicide, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure, binds to the biotin binding site
CP-640186
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
CP-640186
-
;
CP-640188
-
molecular inhibitory mechanism, binding structure
Cu2+
-
forward reaction
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
-
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
Cycloxydim
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Diclofop
-
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
diisopropyl phosphorofluoridate
-
-
diphosphate
-
-
docosanoyl-CoA
-
-
Double-stranded DNA
-
inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase by complex formation and influencing the active site structure, while substrates malonyl-CoA and biocytin inhibit DNA-carboxyltransferase complex formation, overview. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
DTNB
-
complete inhibition at 0.02 mM
DTT
Q877I4 and Q877I3 and Q877I5
5-10 mM, 12% inhibition
ethyl (1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)carbamate
-
-
ethyl (1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
-
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclo-hexyl]-methyl]carbamate
-
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
ethyl(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)carbamate
-
-
ethylene glycol monomethyl ether
-
-
fatty acyl-CoA ester
-
-
fenoxaprop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
fenoxaprop
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
fenoxaprop
-
a specific inhibitor of the cytosolic ACCase, does not affect the activity of chloroplast ACCase
fenoxaprop-P-ethyl
-
-
Fluazifop
-
ACCase2 isoform is about 1/150 as sensitive as ACCase1 isoform
Fluazifop
Q9U755
slight inhibition
FOP herbicides
-
IC50 of 0.005-0.02 mM
-
H2O2
-
dark enzyme completely inhibited at 2 mM, slight activity observed with light enzyme
Haloxyfop
-
0.001 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
Haloxyfop
Q9U755
-
Haloxyfop
-
-
Haloxyfop
-
competitive inhibition
Haloxyfop
-
herbicide, molecular inhibition mechanism, active site binding structure involving Tyr1738 and Phe1956, binding induces large conformational changes in the enzyme
Haloxyfop
-
herbicide, binding structure and inhibition mechanism, binds to an allosteric site
Haloxyfop
-
;
Haloxyfop
-
mutant isozymes confer resistance to the ACCase inhibitor in vivo
Haloxyfop
-
a herbicide
HCO3-
-
competitive inhibition versus phosphate
heparin
-
the DNA mimic inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
High molecular weight protein
-
from rat liver cytosol, approximately 1500000-2000000 Da
-
iodoacetamide
-
-
K+
Q877I4 and Q877I3 and Q877I5
-
leptin
-
-
-
lignoceroyl-CoA
-
-
Linolenoyl-CoA
-
-
linoleoyl-CoA
-
-
long-chain acyl-CoA thioesters
-
-
Long-chain fatty acids
-
-
Long-chain fatty acids
O00763, Q13085
;
Long-chain fatty acids
Q5SWU9, Q6JIZ0
;
Long-chain fatty acids
-
-
Long-chain fatty acids
O70151, P11497
;
Long-chain fatty acids
-
potent feedback inhibition
malonyl-CoA
-
-
malonyl-CoA
-
-
malonyl-CoA
Q8J2Z4, Q8J2Z5
-
malonyl-CoA
-
product inhibition, competitive to acetyl-CoA
malonyl-CoA
O00763, Q13085
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
Q5SWU9, Q6JIZ0
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
-
product inhibition, competitive to acetyl-CoA
malonyl-CoA
O70151, P11497
product inhibition, competitive to acetyl-CoA; product inhibition, competitive to acetyl-CoA
malonyl-CoA
-
competitive inhibition versus acetyl-CoA
malonyl-CoA
Q877I4 and Q877I3 and Q877I5
0.5 mM, 50-57% inhibition of acetyl-CoA carboxylase
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
-
-
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
-
-
methylmalonyl-CoA
Q877I4 and Q877I3 and Q877I5
0.5 mM, 79% inhibition of acetyl-CoA carboxylase
Mg2+
-
about 10 mM Mg2+ required for maximal activity, inhibition above 15 mM
Mg2+
-
at high concentrations
Mg2+
Q877I4 and Q877I3 and Q877I5
above 4.0 mM
Mn2+
Q877I4 and Q877I3 and Q877I5
above 2.0 mM
moiramide B
-
-
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant subunits AccA and AccD is 6 nM, for the wild-type enzyme in crude extract 15 nM
moiramide B
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
myristoyl-CoA
-
-
N-(1-(2'-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(2,2'-dimethyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(2-methyl-4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(benzyloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
-
-
N-(1-(4-[6-(3-phenoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-ethoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)acetamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)butanamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)cyclopropanecarboxamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)pentanamide
-
-
N-(1-(4-[6-(4-propoxyphenoxy)pyridin-3-yl]phenyl)ethyl)propanamide
-
-
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
; potent and selective inhibitor
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
-
-
N-(1-[4'-(3-butoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-methoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
-
-
N-(1-[4'-(4-benzylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-ethoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-phenoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)butanamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)pentanamide
-
-
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
-
N-(1-[4'-(4-propylphenoxy)biphenyl-4-yl]ethyl)acetamide
-
-
N-(2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(3,4-dimethoxyphenyl)acetamide
-
-
N-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-(2-chloro-4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
-
-
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
-
moderate selective isoform ACC2 inhibitor
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
-
-
N-(4-hydroxy-3-methoxycyclohexa-2,5-dien-1-yl)acetamide
-
-
N-(4-hydroxy-3-methoxyphenyl)acetamide
-
-
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
-
-
-
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
-
-
N-[(R)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
-
N-[(S)-3-[4-(6-isopropoxy-pyridin-3-yloxy)-phenyl]-1-methyl-propyl]-acetamide
-
submicromolar dualACC1/2 inhibitor
-
N-[1'-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)-4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
4% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-N-methylbutanamide
-
83% inhibition at 0.01 mM
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
-
-
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
-
-
N-[1-(4-(6-[4-(benzyloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
-
N-[1-(4-(6-[4-(propan-2-yloxy)phenoxy]pyridin-3-yl)phenyl)ethyl]acetamide
-
-
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
-
-
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
-
-
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
-
-
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
-
-
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
-
-
N-[4-oxo-1'-(10H-phenothiazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
48% inhibition at 0.01 mM
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
-
-
Na+
Q877I4 and Q877I3 and Q877I5
-
NaCl
-
30% inhibition at 100 mM
oxaloacetate
-
weak
oxaloacetate
-
-
p-chloromercuribenzoate
-
-
palmitoleoyl-CoA
-
-
Palmitoyl-1,N6-etheno-CoA
-
-
Palmitoyl-4'-phosphopantetheine
-
-
palmitoyl-CoA
-
-
palmitoyl-CoA
-
-
palmitoyl-CoA
-
-
Palmitoyl-dephospho-CoA
-
-
Palmitoyl-inosine-CoA
-
-
-
Palmitoyl-keto-CoA
-
-
-
Phenyl chloromercuribenzoate
-
-
-
Phenylglyoxal
-
-
phosphoenolpyruvate
-
weak
PII protein
-
recombinant Arabidopsis PII protein inhibits chloroplastic ACCase activity dose-dependently and noncompetitively via binding to its BCCP subunit, and this is completely reversed in the presence of 2-oxoglutarate, pyruvate, or oxaloacetate. PII protein decreases the Vmax of the ACCase reaction without altering the Km for acetyl-CoA
-
pinoxaden
-
development of cross- and multiresistance in Alopecurus myosuroides against the ACCase inhibitor, overview
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
-
-
-
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
propionyl-CoA
-
below 0.1 mM almost as effective as substrate as acetyl-CoA, inhibitory at higher concentrations
pyridoxal 5'-phosphate
-
acetyl-CoA protects
pyridoxal 5'-phosphate
-
-
pyridoxal phosphate
-
-
pyridoxal phosphate
-
weak inhibitor; weak inhibitor
Quizalofop
-
ACCase2 isoform is about 1/2000 as sensitive as ACCase1 isoform. Mixed-type inhibition of ACCase1 isoform with respect to acetyl-CoA or ATP
Quizalofop
-
seed enzyme which carboxylates acety-CoA and propionyl-CoA has two separate active sites. One site binds either acetyl-CoA or propionyl-CoA and is inhibited by quizalofop. The other site is specific for acetyl-CoA and is much less inhibited by quizalofop. The leaf enzyme is not able to carboxylate propionyl-CoA and is insensitive to quizalofop
Quizalofop
-
mesophyll chloroplast isoform reveals 1000fold greater sensitivity than non-mesophyll chloroplast isoform
Quizalofop
Q9U755
-
Rat milk
-
-
-
S-cetyl-CoA
-
-
Sethoxydim
-
0.01 mM, 65-80% inhibition of acetyl-CoA carboxylase I, less than 50% inhibition of acetyl-CoA carboxylase II
Sethoxydim
Q94FR5, Q94FR6, Q94FR7
-
Sethoxydim
-
;
Single-stranded DNA
-
inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview
soraphen A
-
noncompetitive, binds to the BC domain
soraphen A
Q6SZP8
noncompetitive, binds to the BC domain
soraphen A
Q12721
noncompetitive, binds to the BC domain
soraphen A
-
natural macrocyclic polyketid, inhibition mechanism, the inhibitor binds to an allosteric site in vicinity to the active site at the biotin carboxylase domain dimer interface causing only small coformational changes, binding structure and specificity
soraphen A
-
macrocyclic polyketide secreted by soil-dwelling myxobacterium Sorangium cellulosum, acts on the biotin carboxylase domain
soraphen A
-
;
soraphen A
-
-
soraphen A
-
-
stearoyl-CoA
-
-
succinyl-CoA
Q8J2Z4, Q8J2Z5
-
succinyl-CoA
Q877I4 and Q877I3 and Q877I5
0.5 mM, 84% inhibition of acetyl-CoA carboxylase
sulfate
Q877I4 and Q877I3 and Q877I5
25 mM, more than 50% inhibition
tall oil fatty acid
-
-
-
tepraloxydim
-
a herbicide, binding mode and structure-activity relationship, molecular inhibition mechanism, overview
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
-
-
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)-methyl]cyclohexyl]methyl)carbamate
-
-
-
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
-
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
-
-
-
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
-
-
-
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
-
-
-
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]-methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)methyl]-carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]-carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]-methyl]cyclohexyl)-methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]-cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
-
-
-
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-(piperazin-1-yl)quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclo-hexyl]methyl]carbamate acetate
-
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[4-(aminomethyl)phenyl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate acetate
-
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]-methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]-methyl]carbamate
-
-
-
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]-methyl)cyclohexyl]methyl]carbamate
-
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
-
-
tetrahydrofuran
-
-
Xanthrenate
-
-
-
Zn2+
-
forward reaction
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
-
-
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
-
-
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
-
-
-
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
-
-
-
moiramide B
-
potent inhibitor
additional information
-
addition of cations in presence of Mg2+ inhibits
-
additional information
-
3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle
-
additional information
Q9U755
no inhibition with Clethodim, Sethoxydim and Cethoxydim
-
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
herbicide mode and site of action
-
additional information
-
no inhibition by soraphen A
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, overview, FOP herbicides are weak inhibitors of the human enzyme
-
additional information
-
cereal crops are resistant to FOP herbicides, overview
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the murine enzyme
-
additional information
-
cereal crops are resistant to FO herbicides, overview
-
additional information
-
phosphorylation inhibits isozymes Acc1 and Acc2, natural inhibitors and physiological effects, FOP herbicides are weak inhibitors of the rat enzyme
-
additional information
-
FOP herbicides are weak inhibitors of the yeast enzyme
-
additional information
-
no inhibition by soraphen A
-
additional information
-
subunit AccB is a negative autoregulator of the accBC operon, overview
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
no inhibition of the rat enzyme by pyrrolidine dione moiramide B, i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, and its derivatve 6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
additional information
-
inhibitory and antibacterial potencies of pyrrolidine dione derivatives, overview
-
additional information
-
enzyme expression does not depend on light
-
additional information
-
ACCA is not affected by roscovitine
-
additional information
-
synthesis of spiro[chroman-2,4-piperidin]-4-one derivatives as ACC inhibitors, overview
-
additional information
-
activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase. ACC is inhibited in Cu-deficient cerebella
-
additional information
-
product inhibition analysis, inhibition patterns, overview
-
additional information
-
synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases containing biphenyl or 3-phenyl pyridine cores
-
additional information
-
disubstituted (4-piperidinyl)-piperazine derivatives act as ACC1/2 non-selective inhibitors
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, effectively reduces ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells, overview
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
an ethanol extract of Polygonum hypoleucum, the Taiwan tuber fleece flower, shows high inhibitory activity against ACC in liver microsomes with IC50 = 0.03 mg/ml. After 4 weeks of feeding, body weight and levels of blood glucose, insulin, triacylglycerol, total cholesterol, and leptin are significantly reduced in mice, overview
-
additional information
-
resistance mechanisms, overview
-
additional information
-
inhibition of stearoyl-CoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
Biocytin
-
biotin derivative, can partly substitute for biotin
biotin
-
induces the enzyme
biotin
-
required for subunit AccB activity, biotin is not involved in regulation of operon accBC transcription
biotin
-
required for activity
biotin
-
dependent on
biotin
Q877I4 and Q877I3 and Q877I5
biotin-dependent enzyme
Bovine serum albumin
-
stimulates
-
Bovine serum albumin
-
-
-
citrate
-
Wayne enzyme: slight stimulation up to 5 mM, strong inhibition above
citrate
-
stimulates at 2 mM, inhibits at higher concentrations
citrate
-
maximal stimulation at 20 mM, 3fold
citrate
-
no effect
citrate
-
completely inactive in absence of the allosteric activator citrate
citrate
-
completely inactive in absence of the allosteric activator citrate; maximal activation at 25-30 mM
citrate
-
nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate
citrate
-
6fold stimulation by 0.03 M citrate; completely inactive in absence of the allosteric activator citrate
citrate
-
activates
citrate
-
no effect
citrate
Pigeon
-
-
citrate
-
activates; maximal activation at 3.0 mM, 2fold
citrate
-
weak activity in absence of citrate
citrate
-
no effect
citrate
-
maximal stimulation of 25%, significant activity in absence of citrate
citrate
-
up to 1 mM no effect on isoform ACCase I activity, inhibitory above. 0.25-10 mM stimulates isoform ACCase 2 activity
citrate
-
allosteric activation, kinetics
citrate
O00763, Q13085
allosteric activation, kinetics; allosteric activation, kinetics
citrate
Q5SWU9, Q6JIZ0
allosteric activation, kinetics; allosteric activation, kinetics
citrate
-
allosteric activation, kinetics
citrate
O70151, P11497
allosteric activation, kinetics; allosteric activation, kinetics
citrate
-
feedforward allosteric activator
citrate
-
barely detectable activity without citrate; barely detectable activity without citrate
citrate
-
barely detectable activity without citrate
citrate
-
an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilization
citrate
-
activates both by increasing kcat and kcat/KM for ATP and acetyl-CoA, has a putative regulatory function on ACC2
D-glutamate
-
allosteric activation
D-glutamate
O00763, Q13085
allosteric activation; allosteric activation
D-glutamate
Q5SWU9, Q6JIZ0
allosteric activation; allosteric activation
D-glutamate
-
allosteric activation
D-glutamate
O70151, P11497
allosteric activation; allosteric activation
dithiothreitol
-
light enzyme is activated 2fold, dark enzyme is activated 6fold, carboxyltransferase but not biotin carboxylase reaction found to be redox regulated
glucose
-
11.1-16.7 mM, significant increase of enzyme expression
glutamate
-
role as physiological activator postulated, 4fold activation in absence of citrate, affects phosphorylation of enzyme
Insulin
-
ACC specific activity is increased in response to insulin
-
Isocitrate
-
nearly absolute requirement for tricarboxylate activators such as citrate or isocitrate
Isocitrate
-
maximal activation at 3 mM
palmitoyl-CoA
Q877I4 and Q877I3 and Q877I5
slight stimulative effect on acetyl-CoA carboxylase (116%) and propionyl-CoA carboxylase (135%)
Phospholipids
-
stimulate
Polyethylene glycols
-
of MW 7500 or 3000, activate
stevioside
-
0.001 mM, in the presence of 16.7 mM glucose
L-glutamate
-
-
additional information
-
enzyme activated by light
-
additional information
-
highest activity when fed a high carbohydrate, low fat diet
-
additional information
-
3,5,3'-triiodothyronine stimulates a 7fold increase in transcription in embryo hepatocytes cell culture
-
additional information
-
more than 200% increase in activity when rats were treated with troglitazone for 18 days
-
additional information
-
the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate
-
additional information
-
enzyme expression does not depend on light
-
additional information
-
stevioside does not influence activity in the presence of 11.1 mM glucose
-
additional information
-
human cytomegalovirus infection also induces isoform ACC1's enzymatic activity
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1.25
-
acetodethio-CoA
-
-
0.0002
-
acetyl-CoA
-
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25C
0.01
-
acetyl-CoA
-
cytosolic enzyme from strain Rothamsted, pH 8.0, 30C
0.013
-
acetyl-CoA
-
mutant enzyme
0.021
-
acetyl-CoA
-
wild type enzyme
0.0215
-
acetyl-CoA
-
adipose tissue
0.025
-
acetyl-CoA
-
-
0.0317
-
acetyl-CoA
-
hindlimb muscle
0.034
-
acetyl-CoA
-
at 37C
0.037
-
acetyl-CoA
-
at 37C
0.048
-
acetyl-CoA
-
pH 7.5, recombinant enzyme
0.05
-
acetyl-CoA
-
-
0.05
-
acetyl-CoA
-
-
0.05
-
acetyl-CoA
-
mesophyll chloroplast isoform
0.058
-
acetyl-CoA
-
at 37C
0.06
-
acetyl-CoA
Q8J2Z4, Q8J2Z5
pH 7.5, 65C
0.074
-
acetyl-CoA
-
-
0.09
-
acetyl-CoA
-
non-mesophyll chloroplast isoform
0.095
-
acetyl-CoA
-
mesophyll chloroplast isoform
0.1
-
acetyl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30C
0.11
-
acetyl-CoA
-
-
0.11
-
acetyl-CoA
-
cytosolic enzyme from strain Notts A1, pH 8.0, 30C
0.11
-
acetyl-CoA
-
cytosolic enzyme, pH 8.0, 30C
0.12
-
acetyl-CoA
-
plastidic enzyme, pH 8.0, 30C
0.14
-
acetyl-CoA
-
plastidic enzyme from strain Rothamsted, pH 8.0, 30C
0.14
-
acetyl-CoA
Q12721
pH 8.0, 30C, recombinant enzyme
0.142
-
acetyl-CoA
-
-
0.15
-
acetyl-CoA
-
-
0.15
-
acetyl-CoA
-
MgATP2-, mutant enzyme
0.16
-
acetyl-CoA
-
plastidic enzyme from strain Notts A1, pH 8.0, 30C
0.17
-
acetyl-CoA
-
9686 enzyme
0.17
-
acetyl-CoA
Q877I4 and Q877I3 and Q877I5
pH 7.5, 70C
0.2
-
acetyl-CoA
-
plastidic enzyme, pH 8.0, 30C
0.226
-
acetyl-CoA
-
-
0.233
-
acetyl-CoA
-
-
0.26
-
acetyl-CoA
-
-
0.32
-
acetyl-CoA
-
Wayne enzyme
0.392
-
acetyl-CoA
-
pH 8.0
1.2
-
acetyl-CoA
-
mesophyll chloroplast isoform
0.015
-
ATP
-
-
0.038
-
ATP
-
-
0.038
-
ATP
-
propionyl-CoA
0.04
-
ATP
-
non-mesophyll chloroplast isoform
0.04
-
ATP
Q8J2Z4, Q8J2Z5
pH 7.5, 65C
0.052
-
ATP
-
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25C
0.0576
-
ATP
-
hindlimb muscle
0.0588
-
ATP
-
second value 0.227 mM
0.08
-
ATP
-
plastidic enzyme from strain Rothamsted, pH 8.0, 30C
0.08
-
ATP
-
cytosolic enzyme, pH 8.0, 30C; plastidic enzyme, pH 8.0, 30C
0.1
-
ATP
-
propionyl-CoA
0.105
-
ATP
-
pH 8.0
0.1065
-
ATP
-
adipose tissue
0.12
-
ATP
-
cytosolic enzyme, pH 8.0, 30C
0.12
-
ATP
-
at 37C
0.125
-
ATP
-
pH 7.5, recombinant enzyme
0.14
-
ATP
-
9686 enzyme
0.15
-
ATP
-
plastidic enzyme, pH 8.0, 30C
0.18
-
ATP
-
cytosolic enzyme from strain Rothamsted, pH 8.0, 30C
0.19
-
ATP
Q12721
pH 8.0, 30C, recombinant enzyme
0.227
-
ATP
-
second value 0.0588 mM
0.46
-
ATP
-
Wayne enzyme
0.47
-
ATP
-
plastidic enzyme from strain Notts A1, pH 8.0, 30C
0.5
-
ATP
-
cytosolic enzyme from strain Notts A1, pH 8.0, 30C
10
-
Biocytin
-
pH 8.0, recombinant subunits AccA and AccD
70
-
Biocytin
-
pH 8.0, recombinant subunits AccA and AccD
0.1
-
biotin
-
isolated biotin carboxylase domain
3
-
biotin
-
isolated carboxyltransferase domain
0.099
-
Butyryl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30C
0.143
-
Butyryl-CoA
-
-
0.3
-
HCO3-
Q8J2Z4, Q8J2Z5
pH 7.5, 65C
0.39
-
HCO3-
-
cytosolic enzyme, pH 8.0, 30C
0.6
-
HCO3-
-
non-mesophyll chloroplast isoform
0.645
-
HCO3-
-
pH 8.0
1.09
-
HCO3-
-
plastidic enzyme, pH 8.0, 30C
1.13
-
HCO3-
-
Wayne enzyme
1.15
-
HCO3-
-
plastidic enzyme, pH 8.0, 30C
1.25
-
HCO3-
-
cytosolic enzyme from strain Notts A1, pH 8.0, 30C
1.38
-
HCO3-
-
plastidic enzyme from strain Rothamsted, pH 8.0, 30C
1.38
-
HCO3-
-
cytosolic enzyme, pH 8.0, 30C
1.4
-
HCO3-
-
-
1.56
-
HCO3-
-
9686 enzyme
1.64
-
HCO3-
-
plastidic enzyme from strain Notts A1, pH 8.0, 30C
1.75
-
HCO3-
-
cytosolic enzyme from strain Rothamsted, pH 8.0, 30C
2.1
-
HCO3-
-
pH 7.5, recombinant enzyme
2.25
-
HCO3-
-
-
2.5
-
HCO3-
-
hindlimb muscle
2.73
-
HCO3-
-
adipose tissue
2.8
3.5
HCO3-
-
wild type
3
3.5
HCO3-
-
mutant enzyme
3
-
HCO3-
-
-
3
-
HCO3-
-
at 37C
4.7
-
HCO3-
-
-
5.1
-
HCO3-
-
at 37C
12.8
-
HCO3-
-
at 37C
0.016
-
malonyl-CoA
-
-
0.075
-
malonyl-CoA
-
pH 8.0, recombinant wild-type enzyme
0.1
-
malonyl-CoA
-
pH 8.0, recombinant subunits AccA and AccD
0.15
-
malonyl-CoA
-
pH 8.0, recombinant subunits AccA and AccD
0.75
-
malonyl-CoA
-
pH 8.0, recombinant mutant enzymes
0.83
-
Mg2+
-
pH 8.0
0.065
-
MgATP2-
-
-
0.07
-
MgATP2-
-
-
0.07
-
MgATP2-
-
ATP
0.045
-
propionyl-CoA
-
-
0.092
-
propionyl-CoA
-
wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30C
0.144
-
propionyl-CoA
-
pH 8.0
0.16
0.19
MgATP2-
-
wild type enzyme
additional information
-
additional information
-
-
-
additional information
-
additional information
-
effect of citrate or isocitrate on Km-values
-
additional information
-
additional information
-
Km-values in presence and absence of 5% polyethylene glycol 3350
-
additional information
-
additional information
-
kinetics of chimeric complexes of wild-type and mutant propionyl-CoA carboxylase, EC 6.4.1.3, subunits and acetyl-CoA carboxylase subunits
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
-
kinetics of recombinant wild-type and mutant enzymes
-
additional information
-
additional information
-
steady-state kinetic analysis of ACC2, kinetic mechanism, overview
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.192
-
acetyl-CoA
-
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25C
2
8
acetyl-CoA
Q8J2Z4, Q8J2Z5
pH 7.5, 65C; pH 7.5, 65C; pH 7.5, 65C
2.9
-
acetyl-CoA
-
pH 7.5, recombinant enzyme
10.1
-
acetyl-CoA
-
at 37C
11.6
-
acetyl-CoA
-
at 37C
11.8
-
acetyl-CoA
-
at 37C
0.155
-
ATP
-
in 50 mM HEPES (pH 7.5), 2.0 mM MgCl2, 2.0 mM ATP, 2.0 mM potassium citrate, 12.5 mM sodium bicarbonate, 1 mg/ml bovine serum albumin, and 0.005 mM acetyl-CoA, at 25C
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0049
-
CP-640186
-
-
0.0012
-
heparin
-
versus malonyl-CoA
0.0022
-
heparin
-
versus biocytin
0.009
-
malonyl-CoA
-
-
0.0008
-
palmitoyl-CoA
-
-
0.0342
-
Single-stranded DNA
-
versus biocytin
0.085
-
Single-stranded DNA
-
versus malonyl-CoA
2.1e-06
-
soraphen A
Q12721
recombinant enzyme, pH 8.0, 30C
5e-06
-
moiramide B
-
-
additional information
-
additional information
Q12721
soraphen A dissociation constant is 0.8 nM
-
additional information
-
additional information
-
inhibition kinetics
-
additional information
-
additional information
-
dissociation constants of inhibitors CP-640186 and CP-640188
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
-
product inhibition kinetics, detailed overview
-
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00029
-
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
ACC1/2
0.000157
-
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
-
ACC1/2
0.000155
-
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
ACC1/2
0.000248
-
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000869
-
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000434
-
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000842
-
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
ACC1
0.000663
-
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
ACC1
0.001
-
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
above, ACC2
0.000505
-
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
-
ACC2
0.00297
-
(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoic acid
-
ACC1
0.00891
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
-
ACC1
0.00301
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
-
ACC1
0.00127
-
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
-
ACC1
7.5e-05
-
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4e-06
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM
1.1e-05
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the wild-type enzyme in crude extract 11 nM
9.1e-05
-
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
3.7e-05
-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM
0.000288
-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
, for IC50 for the wild-type enzyme in crude extract 288 nM
0.00054
-
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
0.001
-
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
above, ACC2
0.00162
-
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.000163
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.0004
-
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
0.001
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
above, ACC2
0.00132
-
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.000562
-
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.000634
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.000641
-
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
0.00253
-
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.00085
-
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.00221
-
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
5.5e-05
-
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
-
ACC1 and ACC2
6e-06
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
1.4e-05
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
2.7e-05
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
2e-06
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
2.6e-05
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
3.6e-05
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
6.1e-05
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
0.0012
-
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
0.000303
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
-
ACC1
6.1e-06
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
3.1e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
7.5e-06
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
4.5e-06
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.8e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
7.4e-06
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
1.9e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
3e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.7e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
3.9e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
7.6e-06
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.8e-05
-
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
3.1e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
6.2e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
2.7e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
5.8e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
9.8e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
4.5e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
4.1e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
1.2e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000117
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
3.8e-05
-
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.001864
-
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000242
-
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000131
-
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
ACC1/2
0.000184
-
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
ACC1/2
5.2e-05
-
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
ACC1/2
6.8e-05
-
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
ACC1/2
7.6e-05
-
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
-
ACC1/2
0.000102
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
-
ACC1/2
0.000169
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
-
ACC1/2
0.000126
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
-
ACC1/2
0.000115
-
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
-
ACC1/2
7.6e-05
-
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
0.000117
-
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.000127
-
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
6.9e-05
-
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.2e-05
-
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
5.7e-05
-
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3.2e-05
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3.7e-05
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
2.1e-05
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3e-05
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
5.5e-05
-
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.7e-05
-
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3.3e-05
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
3.3e-05
-
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
5.9e-05
-
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3e-05
-
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.000169
-
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
6.1e-05
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.9e-05
-
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3.3e-05
-
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
3.6e-05
-
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.8e-05
-
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.7e-05
-
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.000105
-
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.000207
-
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000597
-
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000131
-
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
0.000144
-
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
1.7e-05
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
3.2e-05
-
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
1.2e-05
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
2e-05
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC2
0.000249
-
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
ACC1
0.000766
-
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
ACC1
4.5e-06
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC2
3e-05
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
2.46e-05
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
ACC1
0.000154
-
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
ACC1
0.000109
-
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
8.1e-05
-
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
4.9e-05
-
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
7.4e-05
-
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea maleate
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37C
-
3.2e-05
-
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
-
ACC1/2
0.00015
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
isoform ACC2, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.0012
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
isoform ACC1, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.0029
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
isoform ACC1, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.003
-
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
-
isoform ACC2, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.0001
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
7.2e-05
-
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.7e-05
-
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.7e-05
-
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
2.7e-05
-
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
7e-05
-
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
4.2e-05
-
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
8.4e-06
-
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.00338
-
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
ACC1
0.001
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37C
-
0.00013
-
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37C
-
0.051
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
0.076
-
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
0.00184
-
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
ACC2
0.00206
-
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
ACC1
0.000718
-
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
ACC2
0.000753
-
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
-
ACC1
0.000188
-
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
ACC1
0.000214
-
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
-
ACC2
0.038
-
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
0.054
-
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
0.0025
-
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
0.0057
-
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
7.3e-05
-
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
ACC1/2
0.558
-
3,3,14,14-tetramethylhexadecanedioic acid
-
-
0.000111
-
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
-
ACC2
0.000216
-
3,4-dihydroxycyclohexa-2,5-diene-1-carboxylic acid
-
ACC1
0.000126
-
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
-
ACC2
0.000172
-
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid
-
ACC1
0.0035
-
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
0.017
-
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
6.7e-05
-
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
-
ACC1/2
0.00075
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37C
-
0.0029
-
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37C
-
0.000169
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
-
ACC1/2
9.5e-05
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
-
ACC1/2
0.000151
-
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
-
ACC1/2
8e-05
-
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
2.3e-05
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
9.8e-05
-
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC2
6.1e-05
-
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
8.6e-05
-
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
3.4e-05
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC1
4.8e-05
-
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
-
ACC2
0.0011
-
5-(tetradecyloxy)-2-furoyl-CoA
-
pH 7.5, 37C, partially purified native enzyme
0.0009
-
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
0.0046
-
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
0.0018
-
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
0.028
-
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
1.9e-05
-
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.9e-05
-
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.000101
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
0.000101
-
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
1.2e-05
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
2.6e-05
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
2.6e-05
-
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
1.9e-05
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
2.6e-05
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
2.6e-05
-
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
5.1e-05
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
6e-05
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
6e-05
-
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
1.6e-05
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.6e-05
-
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
6.5e-06
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
0.000104
-
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
2.6e-05
-
5-methoxy-1'-{[2-(pyridin-2-yl)-1H-benzimidazol-6-yl]carbonyl}spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.6e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
ACC2
6.5e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
ACC2
6.5e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
-
ACC1
1.1e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
ACC2
4.3e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
ACC2
4.3e-05
-
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
-
ACC1
0.0035
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
0.0043
-
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
5.4e-05
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
9.7e-06
-
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
in 250 mM phosphate buffer, at 37C, pH not specified in the publication
0.000975
-
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
ACC1
0.00135
-
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
ACC1
0.000182
-
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
-
ACC1
0.000366
-
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
-
ACC1
3.6e-05
-
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
2.2e-05
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
4.8e-05
-
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
0.000236
-
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
6.4e-06
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1.3e-05
-
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.00183
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.00139
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC1
0.00213
-
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
-
ACC2
1e-06
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM
8e-06
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC 50 for the wild-type enzyme in crude extract 8 nM
5e-05
-
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
9.9e-05
-
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
5.9e-05
-
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
-
-
0.000208
-
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
-
-
1.3e-05
-
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
0.000305
-
andrimid
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
6e-05
-
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
-
ACC1/2
0.000325
-
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
-
ACC1
9.1e-05
-
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
9.5e-05
-
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000161
-
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000239
-
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
0.000121
-
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
-
ACC1/2
7e-05
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
isoform ACC2, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.00028
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
isoform ACC2, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.00059
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
isoform ACC1, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
0.00091
-
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
-
isoform ACC1, in 50 mM Tris-acetate, at 37C, pH not specified in the publication
6.6e-05
-
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
-
ACC1/2
0.002112
-
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
-
ACC1/2
0.00024
-
Clethodim
-
wild type enzyme
0.00426
-
Clethodim
-
mutant enzyme I1781L
0.00976
-
Clethodim
-
mutant enzyme D2078G
0.01157
-
Clethodim
-
mutant enzyme C2088A
6e-05
-
CP-640186
-
;
9.2e-05
-
CP-640186
-
ACC1
0.008
-
CP-640186
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site