Information on EC 6.4.1.2 - acetyl-CoA carboxylase

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The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
6.4.1.2
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RECOMMENDED NAME
GeneOntology No.
acetyl-CoA carboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-hydroxypropanoate cycle
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3-hydroxypropanoate/4-hydroxybutanate cycle
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Aflatoxin biosynthesis
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Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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biotin biosynthesis
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biotin-carboxyl carrier protein assembly
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candicidin biosynthesis
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Carbon fixation pathways in prokaryotes
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CO2 fixation in Crenarchaeota
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Fatty acid biosynthesis
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fatty acid biosynthesis initiation I
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glyoxylate assimilation
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jadomycin biosynthesis
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lipid metabolism
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Metabolic pathways
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Microbial metabolism in diverse environments
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octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)
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Propanoate metabolism
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Pyruvate metabolism
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Tetracycline biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:carbon-dioxide ligase (ADP-forming)
A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-93-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain So4a, DSM 3191
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Manually annotated by BRENDA team
strain So4a, DSM 3191
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain W09B6
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Manually annotated by BRENDA team
strain W09B6
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
strain OK-70-fl, DSM 636
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Manually annotated by BRENDA team
strain OK-70fl, DSM 636
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Manually annotated by BRENDA team
single gene
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Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
zebrafish
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Manually annotated by BRENDA team
Chinese sprangletop
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Manually annotated by BRENDA team
herbicide-sensitive and herbicide-resistant biotypes
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Manually annotated by BRENDA team
strain MG1655
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Manually annotated by BRENDA team
acetyl-CoA carboxylase and propionyl-CoA carboxylase are different enzymes
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
diclofop-resistant and diclofop-susceptible biotype
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain Guy11
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Manually annotated by BRENDA team
strain Guy11
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
genotype US-1
SwissProt
Manually annotated by BRENDA team
Pigeon
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Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
biotin carboxylase domain
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 12-53, the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
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Manually annotated by BRENDA team
strain 12-53, the activities of EC 6.4.1.2 and EC 6.4.1.3 are located on a single protein
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Manually annotated by BRENDA team
strain X2180-1A, genes HFA1 and ACC1
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Manually annotated by BRENDA team
herbicide-sensitive and herbicide-resistant biotypes
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain Krs23, DSM 6482
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Manually annotated by BRENDA team
puffer fish
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Manually annotated by BRENDA team
strain RH
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Zea mays sensitive
herbicide sensitive strain
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetodethio-CoA + HCO3-
?
show the reaction diagram
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ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
show the reaction diagram
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malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
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ir
ATP + biotin + HCO3-
ADP + ? + phosphate
show the reaction diagram
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free biotin can be used as carboxyl acceptor with low activity
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?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
show the reaction diagram
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
ATP + propionyl-CoA + HCO3-
ADP + methylmalonyl-CoA + phosphate
show the reaction diagram
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r
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
show the reaction diagram
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
dATP + acetyl-CoA + HCO3-
dADP + phosphate + malonyl-CoA
show the reaction diagram
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GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
show the reaction diagram
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-CoA + HCO3-
?
show the reaction diagram
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
show the reaction diagram
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
show the reaction diagram
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
show the reaction diagram
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malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
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ir
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
show the reaction diagram
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
show the reaction diagram
-
participation in an anaplerotic pathway causes preference for propionyl-CoA as substrate
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?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE