Activating Compound | Comment | Organism | Structure |
---|---|---|---|
biotin | required for subunit AccB activity, biotin is not involved in regulation of operon accBC transcription | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
genes accA, accB, accC, and accD, operon accBC shows nonlinear response to the gene copy number so that 50 or more copies result in an only 2-3fold increase in subunits AccB and AccC, AccB is a negative regulator for transcription of the accBC operon | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a constructed truncation mutant of subunit AccB comprising the 68 N-terminal residues is sufficient for negative regulation of accBC operon transcription, an accA and accB null mutant strain expressing the accB gene of Rhizobium trifolii is not reduced in growth under conditions that result in highly reduced growth for the wild-type strain | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | subunit AccB is a negative autoregulator of the accBC operon, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Escherichia coli | first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB | ADP + malonyl-CoA + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | the enzyme is biotinylated at the biotinyl domain of subunit AccB by the biotin-[acetyl-CoA carboxylase] ligase BirA, EC 6.3.4.15 | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Escherichia coli | ADP + malonyl-CoA + phosphate | - |
? | |
ATP + acetyl-CoA + HCO3- | first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB | Escherichia coli | ADP + malonyl-CoA + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | the four subunits are encoded by genes accA, accB, accC, and accD | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
ACC | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |