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Literature summary for 6.4.1.2 extracted from

  • James, E.S.; Cronan, J.E.
    Expression of two Escherichia coli acetyl-CoA carboxylase subunits is autoregulated (2004), J. Biol. Chem., 279, 2520-2527.
    View publication on PubMed
Search for more literature for 6.4.1.2

Activating Compound

Activating Compound Comment Organism Structure
biotin required for subunit AccB activity, biotin is not involved in regulation of operon accBC transcription Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
genes accA, accB, accC, and accD, operon accBC shows nonlinear response to the gene copy number so that 50 or more copies result in an only 2-3fold increase in subunits AccB and AccC, AccB is a negative regulator for transcription of the accBC operon Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information a constructed truncation mutant of subunit AccB comprising the 68 N-terminal residues is sufficient for negative regulation of accBC operon transcription, an accA and accB null mutant strain expressing the accB gene of Rhizobium trifolii is not reduced in growth under conditions that result in highly reduced growth for the wild-type strain Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information subunit AccB is a negative autoregulator of the accBC operon, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Escherichia coli first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB ADP + malonyl-CoA + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the enzyme is biotinylated at the biotinyl domain of subunit AccB by the biotin-[acetyl-CoA carboxylase] ligase BirA, EC 6.3.4.15 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?
ATP + acetyl-CoA + HCO3- first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB Escherichia coli ADP + malonyl-CoA + phosphate
-
 ?

Subunits

Subunits Comment Organism
tetramer the four subunits are encoded by genes accA, accB, accC, and accD Escherichia coli

Synonyms

Synonyms Comment Organism
ACC
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli