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Literature summary for 6.4.1.2 extracted from

  • Thampy, K.G.; Wakil, S.J.
    Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver (1988), J. Biol. Chem., 263, 6447-6453.
    View publication on PubMed
Search for more literature for 6.4.1.2

Metals/Ions

Metals/Ions Comment Organism Structure
phosphate phosphate content of the 10000000 MW enzyme form: 4.0 mol of phosphate per mol of subunit. Phosphate content of the 2000000 MW enzyme form: 6.0 mol phosphate per mol of subunit. The 10000000 MW subunit and the 2000000 MW subunit are interconvertible by phosphorylation and dephosphorylation. Dephosphorylation by [acetyl-CoA carboxylase]-phosphatase 2 activates the enzyme and reduces its dependence on citrate Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
 x * 250000, SDS-PAGE, 2 polymeric forms of MW 2000000 Da, and MW 10000000 Da Rattus norvegicus
2000000
-
 gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000,interconvertible by phosphorylation and dephosphorylation. The 2000000 MW form predominates in preparations of unfrozen liver and is converted to the 10000000 MW form by dephosphorylation Rattus norvegicus
10000000
-
 gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000, interconvertible by phosphorylation and dephosphorylation. The 10000000 MW form predomionantly exists in preparations of freeze-clamped liver Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

Subunits Comment Organism
polymer x * 250000, SDS-PAGE, 2 polymeric forms of MW 2000000 Da, and MW 10000000 Da Rattus norvegicus