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Literature summary for 6.4.1.2 extracted from
- Purification and characterization of rat skeletal muscle acetyl-CoA carboxylase (1995), Eur. J. Biochem., 231, 192-198.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| malonyl-CoA | - |
Rattus norvegicus |  |
| palmitoyl-CoA | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0215 | - |
acetyl-CoA | adipose tissue | Rattus norvegicus | |
| 0.0317 | - |
acetyl-CoA | hindlimb muscle | Rattus norvegicus | |
| 0.0576 | - |
ATP | hindlimb muscle | Rattus norvegicus | |
| 0.1065 | - |
ATP | adipose tissue | Rattus norvegicus | |
| 2.25 | - |
HCO3- | - |
Rattus norvegicus | |
| 2.73 | - |
HCO3- | adipose tissue | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 265000 | - |
x * 265000, adipose tissue, SDS-PAGE | Rattus norvegicus |
| 265000 | - |
x * 265000, and a minor band at 280000 MW, liver, SDS-PAGE | Rattus norvegicus |
| 272000 | - |
x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| hindlimb muscle | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| muscle | hindlimb | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.6 | - |
hindlimb muscle | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for up to 8 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE | Rattus norvegicus |
| ? | x * 265000, adipose tissue, SDS-PAGE | Rattus norvegicus |
| ? | x * 265000, and a minor band at 280000 MW, liver, SDS-PAGE | Rattus norvegicus |
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