Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Rattus norvegicus | key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation | ADP + phosphate + malonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
insulin resistant strain JCR:LA-cp and wild type rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | AMP-activated protein kinase phosphorylates and inactivates enzyme activity in liver | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
no differences in activity in muscle | Rattus norvegicus |
0.00033 | - |
wild type rat liver, 37°C | Rattus norvegicus |
0.00875 | - |
JCR:LA-cp rat liver, 37°C | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
ATP + acetyl-CoA + HCO3- | key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation | Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
biotin | enzyme-bound | Rattus norvegicus |