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Literature summary for 6.4.1.2 extracted from
- Acetyl-CoA carboxylase and fatty acid synthase from lactating rabbit and rat mammary gland (1981), Methods Enzymol., 71, 26-33.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | - |
Rattus norvegicus | |
| bovine serum albumin | stimulates | Oryctolagus cuniculus | |
| citrate | completely inactive in absence of the allosteric activator citrate | Rattus norvegicus |  |
| citrate | completely inactive in absence of the allosteric activator citrate | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | concentration of Mg2+ must be sufficient to allow chelation by both ATP and citrate. Free Mg2+ inhibits | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
linear polymers of MW several million | Oryctolagus cuniculus |
| 252000 | - |
x * 252000, linear polymers of MW several million | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mammary gland | - |
Rattus norvegicus | - |
| mammary gland | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.2 | - |
- |
Oryctolagus cuniculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, 35% ethanediol, stable for at least 1 month | Oryctolagus cuniculus |
| 20°C, 100 mM sodium phosphate, 25 mM sodium citrate, pH 7.0, stable for several days | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + acetyl-CoA + HCO3- | - |
Oryctolagus cuniculus | ADP + phosphate + malonyl-CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| polymer | - |
Rattus norvegicus |
| polymer | x * 252000, linear polymers of MW several million | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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