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Literature summary for 6.4.1.2 extracted from

  • Vigueira, P.A.; Paul, K.S.
    Requirement for acetyl-CoA carboxylase in Trypanosoma brucei is dependent upon the growth environment (2011), Mol. Microbiol., 80, 117-132.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Trypanosoma brucei 5737
-

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Trypanosoma brucei ADP + malonyl-CoA + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * about 200000, SDS-PAGE Trypanosoma brucei
? x * about 243000, estimated from amino acid sequence Trypanosoma brucei

Synonyms

Synonyms Comment Organism
ACC
-
 Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Trypanosoma brucei
biotin
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection Trypanosoma brucei
metabolism ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons Trypanosoma brucei
physiological function ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice Trypanosoma brucei