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Literature summary for 6.4.1.2 extracted from

  • Zhang, Y.; Yin, L.; Hillgartner, F.B.
    Thyroid hormone stimulates acetyl-CoA carboxylase-a transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element (2001), J. Biol. Chem., 276, 974-983.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information 3,5,3'-triiodothyronine stimulates a 7fold increase in transcription in embryo hepatocytes cell culture Gallus gallus

Cloned(Commentary)

Cloned (Comment) Organism
-
Gallus gallus

Protein Variants

Protein Variants Comment Organism
additional information deletion of downstream sequences affects the response to 3,5,3'-triiodothyronine Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Gallus gallus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
Gallus gallus ADP + phosphate + malonyl-CoA
-
?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Gallus gallus ADP + phosphate + malonyl-CoA
-
?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Gallus gallus